Prefilled insulin device with reduced injection force: Patient perception and accuracy

Current Medical Research and Opinion

Volumn 24, Issue 9, 2008, Pages 2545-2549

  Pfutzner A ^a   Reimer, T ^a   Hohberg, C ^a   Frokjaeer L P F ^b   Jørgensen, Christina ^b  

^a Institute for Clinical Research and Development   (Germany)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Dose accuracy; FlexPen; Injection force

Indexed keywords

INSULIN ASPART;

ACCURACY; ARTICLE; CLINICAL ARTICLE; CONCEPT FORMATION; CONTROLLED STUDY; DOSE CALCULATION; DRUG DELIVERY SYSTEM; DRUG DOSE COMPARISON; EQUIPMENT DESIGN; HUMAN; HUMIDITY; INJECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT SATISFACTION; QUESTIONNAIRE; REFERENCE VALUE; SELF CONCEPT; SINGLE DRUG DOSE;

HUMANS; INSULIN; PATIENTS; QUESTIONNAIRES; REPRODUCIBILITY OF RESULTS; SYRINGES;

EID: 52049118058     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/03007990802329264     Document Type: Article

References (27)

1. Bashoff EC, Beaser RS. Insulin therapy and the reluctant patient. Overcoming obstacles to success. Postgrad Med 1995; 97:86-90, 3-6
2. Korytkowski M, Niskanen L, Asakura T. FlexPen: addressing issues of confidence and convenience in insulin delivery. Clin Ther 2005;27(Suppl B):S89-100
3. Puxty JA, Hunter DH, Burr WA. Accuracy of insulin injection in elderly patients. Br Med J (Clin Res Ed) 1983;287:1762
4. Kesson CM, Bailie GR. Do diabetic patients inject accurate doses of insulin? Diabetes Care. 1981;4:333
5. Bohannon NJ. Insulin delivery using pen devices. Simple-to-use tools may help young and old alike. Postgrad Med 1999;106:57-8, 61-4, 8
6. Chantelau E, Schiffers T, Schutze J, et al. Effect of patient-selected intensive insulin therapy on quality of life. Patient Educ Couns 1997;30:167-73
7. Kadiri A, Chraibi A, Marouan F, et al. Comparison of NovoPen 3 and syringes/vials in the acceptance of insulin therapy in NIDDM patients with secondary failure to oral hypoglycaemic agents. Diabetes Res Clin Pract 1998;41:15-23
8. Albano S. Assessment of quality of treatment in insulin-treated patients with diabetes using a pre-filled insulin pen. The ORBITER Study Group. Acta Biomed 2004;75:34-9
9. Lombardo F, Salzano G, Messina MF, et al. Compliance and administration methods in management of type 1 diabetes. Acta Biomed 2005;76(Suppl 3):66-9
10. Summers KH, Szeinbach SL, Lenox SM. Preference for insulin delivery systems among current insulin users and nonusers. Clin Ther 2004;26:1498-505
11. Keith K, Nicholson D, Rogers D. Accuracy and precision of low-dose insulin administration using syringes, pen injectors, and a pump. Clin Pediatr (Phila) 2004;43:69-74
12. Lteif AN, Schwenk WF. Accuracy of pen injectors versus insulin syringes in children with type 1 diabetes. Diabetes Care 1999; 22:137-40
13. Coscelli C, Lostia S, Lunetta M, et al. Safety, efficacy, acceptability of a pre-filled insulin pen in diabetic patients over 60 years old. Diabetes Res Clin Pract 1995;28:173-7
14. IMS Health. Estimated number of patients using FlexPen®, based on worldwide sales in number of packs sold, IMS world wide data Q4'07 and Daily Defined Dosage (DDD) for insulin as issued by WHO 2007.
15. Asakura T, Seino H. Insulin dosing accuracy with FlexPen® versus syringe by healthcare professionals and healthy volunteers. Diabetes 2005;54 (Suppl 1):A498-9
16. Asakura T. Comparison of the dosing accuracy of two insulin injection devices. J Clin Res 2005;8:33-40
17. Pfutzner A, Weise A, Sun H, et al. Differences in dose accuracy of insulin pens. in 43rd EASD Annual Meeting, 2007. Amsterdam, The Netherlands.
18. Asakura T, Seino H, Kageyama M, et al. Dosing accuracy of two insulin pre-filled pens. Curr Med Res Opinion 2008;24:1429-34
19. Pen-injectors for medical use - Part 1: Pen-injectors - requirements and test methods. ISO 11608-1:2000-2001.
20. Ziegler D, Gries FA, Spuler M, et al. The epidemiology of diabetic neuropathy. DiaCAN Multicenter Study Group. Diabet Med 1993;(10 Suppl 2):82-6S
21. Schady W, Abuaisha B, Boulton AJ. Observations on severe u1nar neuropathy in diabetes. J Diabetes Complicat 1998; 12:128-32
22. Savas S, Koroglu BK, Koyuncuoglu HR, et al. The effects of the diabetes related soft tissue hand lesions and the reduced hand strength on functional disability of hand in type 2 diabetic patients. Diabetes Res Clin Pract 2007;77:77-83
23. Costa SD, Brackenridge B, Hicks D. A comparison of insulin pen use in the United States and the United Kingdom. Diabet Educ 2002;1:52-6
24. Thurman JE. Insulin pen injection devices for management of patients with type 2 diabetes: considerations based on an endocrinologist's practical experience in the United States. Endocr Pract 2007;13:672-8
25. Bohannon NJ, Ohannesian JP, Burdan AL, et al. Patient and physician satisfaction with the Humulin/Humalog Pen, a new 3.0-mL prefilled pen device for insulin delivery. Clin Ther 2000;22:1049-67
26. Rubin RR, Peyrot M. Quality of life, treatment satisfaction, and treatment preference associated with use of a pen device delivering a prernixed 70/30 insulin aspart suspension (aspart protamine suspension/ soluble aspart) versus alternative treatment strategies. Diabetes Care 2004;27:2495-7
27. Stockl K, Ory C, Vanderplas A, et al. An evaluation of patient preference for an alternative insulin delivery system compared to standard vial and syringe. Curr Med Res Opin 2007;23:133-46