Pioglitazone ameliorates palmitate induced impairment of mitochondrial morphology and function and restores insulin level in βcells

Pharmazie

Volumn 68, Issue 4, 2013, Pages 270-273

  Li, Yao ^a   Zhang, Xinxia ^b   Tong, Nanwei ^b,c  

^a CHENGDU MEDICAL COLLEGE   (China)

^b SICHUAN UNIVERSITY   (China)

^c CHENGDU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; FATTY ACID; GLUCOSE; INSULIN; MESSENGER RNA; NUCLEUS RESPIRATORY FACTOR 1; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PIOGLITAZONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; CELL LINE; CELL STRUCTURE; CELL ULTRASTRUCTURE; DRUG EFFECT; DRUG MECHANISM; ELECTRON MICROSCOPY; GENE EXPRESSION; INSULIN RELEASE; MITOCHONDRION; NICK END LABELING; PANCREAS ISLET BETA CELL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; APOPTOSIS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLOW CYTOMETRY; HEAT-SHOCK PROTEINS; HUMANS; HYPOGLYCEMIC AGENTS; IN SITU NICK-END LABELING; INDICATORS AND REAGENTS; INSULIN; INSULIN-SECRETING CELLS; MICROSCOPY, ELECTRON; MITOCHONDRIA; NUCLEAR RESPIRATORY FACTOR 1; PALMITATES; REAL-TIME POLYMERASE CHAIN REACTION; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS;

EID: 84876221468     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2013.2778     Document Type: Article

References (11)

1. Berger J, Moller DE (2002) The mechanisms of action of PPARs. Ann Rev of Med 53: 409-435.
2. De Souza CT, Gasparetti AL, Pereira-da-Silva M, Araújo EP, Carvalheira JB, Saad MJ, BoscheroAC, Carneiro EM,Velloso LA (2003) Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion. Diabetologia 46: 1522-1531.
3. Gumieniczek A, Hopkała H, Zabek A (2008) Protective effects of a PPARgamma agonist pioglitazone on anti-oxidative system in testis of diabetic rabbits. Pharmazie 63: 377-378.
4. Kawai T, Hirose H, Seto Y, Fujita H, Fujita H, Ukeda K, Saruta T (2002) Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma. Diabetes Res Clin Pract 56: 83-92.
5. Kutoh E (2010) Differential effects of pioglitazone on metabolic parameters in newly diagnosed, drug-naïve Japanese patients with type 2 diabetes with or without metabolic syndrome. Endocr Res 35: 118-127.
6. Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S (2004) Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPAR- 2 in the modulation of insulin secretion. Am J Physiol Endocrinol Metab 286: E560-67.
7. Maechler P, Kennedy ED, Pozzan T, Wollheim CB (1997) Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells. EMBO J 16: 3833-3841.
8. Morgan NG (2009) Fatty acids and beta-cell toxicity. Curr Opin Clin Nutr Metab Care 12: 117-122.
9. Saitoh Y, Chun-ping C, Noma K, Ueno H, Mizuta M, Nakazato M (2008) Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells. Diabetes Obes Metab 10: 564-573.
10. Wu Z, Boss O (2007) Targeting PGC-1 alpha to control energy homeostasis. Expert Opin Ther Targets 11: 1329-1338.
11. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner- Weir S, Weir G, Spiegelman BM (2003) Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell 5: 73-83.