Inhibition of monocarboxylate transporter-mediated absorption of valproic acid by Gegen-Qinlian-Tang

American Journal of Chinese Medicine

Volumn 41, Issue 2, 2013, Pages 369-378

  Liu, Hsueh Jung ^a   Yu, Chung Ping ^b   Hsieh, Yow Wen ^a,b   Tsai, Shang Yuan ^b   Hou, Yu Chi ^a,b  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Gegen Qinlian Tang; Herb Drug Interaction; pharmacokinetics; Valproic Acid

Indexed keywords

CHINESE DRUG; GEGEN QINLIAN TANG; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; CROSSOVER PROCEDURE; DRUG ABSORPTION; FLUORESCENCE POLARIZATION IMMUNOASSAY; HERB DRUG INTERACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT;

ABSORPTION; ANIMALS; ANTICONVULSANTS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; DOWN-REGULATION; DRUG INTERACTIONS; DRUGS, CHINESE HERBAL; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; VALPROIC ACID;

EID: 84876220366     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500274     Document Type: Article

References (20)

1. Bryant, A.E., 3rd and F.E. Dreifuss. Valproic acid hepatic fatalities. III. U.S. experience since 1986. Neurology 46: 465-469, 1996
2. Cato, A., 3rd, G.M. Pollack and K.L. Brouwer. Age-dependent intestinal absorption of valproic acid in the rat. Pharm. Res. 12: 284-290, 1995
3. Cherdshewasart, W., W. Sutjit, K. Pulcharoen and M. Chulasiri. The mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata. Braz. J. Med. Biol. Res. 42: 816-823, 2009
4. Davis, R., D.H. Peters and D. McTavish. Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy. Drugs 47: 332-372, 1994
5. Gibbs, J.P., M.C. Adeyeye, Z. Yang, and D.D. Shen. Valproic acid uptake by bovine brain microvessel endothelial cells: Role of active efflux transport. Epilepsy Res. 58: 53-66, 2004
6. Konishi, Y. and M. Shimizu. Transepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers. Biosci. Biotechnol. Biochem. 67: 856-862,2003
7. Konishi, Y., Y. Hitomi and E. Yoshioka. Intestinal absorption of p-coumaric and gallic acids in rats after oral administration. J. Agric. Food Chem. 52: 2527-2532, 2004
8. Kumar, S., H. Wong, S.A. Yeung, K.W. Riggs, F.S. Abbott and D.W. Rurak. Disposition of valproic acid in maternal, fetal, and newborn sheep. I: Placental transfer, plasma protein binding, and clearance. Drug Metab. Dispos. 28: 845-856, 2000
9. Kuwayama, K., S. Miyauchi, R. Tateoka, H. Abe and N. Kamo. Fluorescein uptake by a monocarboxylic acid transporter in human intestinal Caco-2 cells. Biochem. Pharmacol. 63: 81-88,2002
10. Lu, Y., R. Joerger and C. Wu. Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi. J. Agric. Food Chem. 59: 10934-10942, 2011
11. Ma, B.L., Y.M. Ma, R. Shi, T.M. Wang, N. Zhang, C.H. Wang and Y. Yang. Identification of the toxic constituents in Rhizoma Coptidis. J. Ethnopharmacol. 128: 357-364, 2010
12. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63, 1983
13. Tang, J., Y. Feng, S. Tsao, N. Wang, R. Curtain and Y. Wang. Berberine and Coptidis rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations. J. Ethnopharmacol. 126: 5-17, 2009
14. Ushigome, F., H. Takanaga, H. Matsuo, K. Tsukimori, H. Nakano, H. Ohtani and Y. Sawada. Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). Eur. J. Pharmacol. 417: 169-176, 2001
15. Utoguchi, N. and K.L. Audus. Carrier-mediated transport of valproic acid in BeWo cells, a human trophoblast cell line. Int. J. Pharm. 195: 115-124, 2000
16. Utsunomiya, T., M. Kobayashi, R.B. Pollard and F. Suzuki. Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus. Antimicrob. Agents Chemother. 41: 551-556, 1997
17. Wang, Y., Y. Yao, R. An, L. You and X. Wang. Simultaneous determination of puerarin, daidzein,baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877: 1820-1826, 2009
18. Wu, J.A., A.S. Attele, L. Zhang and C.S. Yuan. Anti-HIV activity of medicinal herbs: usage and potential development. Am. J. Chin. Med. 29: 69-81, 2001
19. Ye, F., L. Xui, J. Yi, W. Zhang and D.Y. Zhang. Anticancer activity of Scutellaria baicalensis and its potential mechanism. J. Altern. Complement. Med. 8: 567-572, 2002
20. Yu, C.P., C.S. Shia, S.Y. Tsai and Y.C. Hou. Pharmacokinetics and relative bioavailability of flavonoids between two dosage forms of Gegen-Qinlian-Tang in rats. Evid. Based Complement. Alternat. Med. 2012. (DOI: 10.1155/2012/308018