The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins

Journal of Cellular Biochemistry

Volumn 114, Issue 6, 2013, Pages 1414-1423

  Zhao, Peishen ^a,c   Nunn, Caroline ^a   Ramineni, Suneela ^b   Hepler, John R ^b   Chidiac, Peter ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Gap Activity; Gap Enhancing Activity; GDI Activity; Intramolecular Interaction; Ras Binding Domain; RGS Proteins

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; NUCLEOTIDE; RAS PROTEIN;

ARTICLE; DISSOCIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION;

CARBACHOL; CHOLINERGIC AGONISTS; ENZYME ACTIVATION; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MUSCARINIC ANTAGONISTS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTOR, MUSCARINIC M2; RECEPTORS, ADRENERGIC, ALPHA-2; RGS PROTEINS; SF9 CELLS; SIGNAL TRANSDUCTION; TROPICAMIDE;

EID: 84876218108     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24483     Document Type: Article

References (28)

1. Abramow-Newerly M, Ming H, Chidiac P,. 2006. Modulation of subfamily B/R4 RGS protein function by14-3-3 proteins. Cell Signal 18: 2209-2222.
2. Cho H, Kim DU, Kehrl JH,. 2005. RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock. J Biol Chem 280: 805-814.
3. Cladman W, Chidiac P,. 2002. Characterization and comparison of RGS2 and RGS4 as GTPase-activating proteins for m2 muscarinic receptor-stimulated G(i). Mol Pharmacol 62: 654-659.
4. Hepler JR, Cladman W, Ramineni S, Hollinger S, Chidiac P,. 2005. Novel activity of RGS14 on Goalpha and Gialpha nucleotide binding and hydrolysis distinct from its RGS domain and GDI activity. Biochemistry 44: 5495-5502.
5. Hollinger S, Taylor JB, Goldman EH, Hepler JR,. 2001. RGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain. J Neurochem 79: 941-949.
6. Hollinger S, Ramineni S, Hepler JR,. 2003. Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i. Biochemistry 42: 811-819.
7. Ishii M, Fujita S, Yamada M, Hosaka Y, Kurachi Y,. 2005. Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action. Biochem J 385: 65-73.
8. Kimple RJ, De Vries L, Tronchere H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP,. 2001. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor activity. J Biol Chem 276: 29275-29281.
9. Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, Hepler JR,. 2010. RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proc Natl Acad Sci U S A 107: 16994-16998.
10. Mao H, Zhao Q, Daigle M, Ghahremani MH, Chidiac P, Albert PR,. 2004. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. J Biol Chem 279: 26314-26322.
11. Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ, Natale DR, Snow BE, Kimple RJ, Pajak A, Watson AJ, Dagnino L, Penninger JM, Siderovski DP, D'Souza SJ,. 2004a. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell 7: 763-769.
12. Martin-McCaffrey L, Willard FS, Pajak A, Dagnino L, Siderovski DP, D'Souza SJ,. 2004b. Analysis of interactions between regulator of G-protein signaling-14 and microtubules. Methods Enzymol 390: 240-258.
13. Martin-McCaffrey L, Willard FS, Pajak A, Dagnino L, Siderovski DP, D'Souza SJ,. 2005. RGS14 is a microtubule-associated protein. Cell Cycle 4: 953-960.
14. Mittal V, Linder ME,. 2004. The RGS14 GoLoco domain discriminates among Galphai isoforms. J Biol Chem 279: 46772-46778.
15. Mittal V, Linder ME,. 2006. Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A. Biochem J 394: 309-315.
16. Neves SR, Ram PT, Iyengar R,. 2002. G protein pathways. Science 296: 1636-1639.
17. Ponting CP,. 1999. Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins. J Mol Med (Berl) 77: 695-698.
18. Rodriguez-Munoz M, de la Torre-Madrid E, Gaitan G, Sanchez-Blazquez P, Garzon J,. 2007. RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons. Cell Signal 19: 2558-2571.
19. Ross EM, Wilkie TM,. 2000. GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69: 795-827.
20. Shu FJ, Ramineni S, Amyot W, Hepler JR,. 2007. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Cell Signal 19: 163-176.
21. Shu FJ, Ramineni S, Hepler JR,. 2010. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. Cell Signal 22: 366-376.
22. Siderovski DP, Willard FS,. 2005. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci 1: 51-66.
23. Sjogren B, Neubig RR,. 2010. Thinking outside of the "RGS box": New approaches to therapeutic targeting of regulators of G protein signaling. Mol Pharmacol 78: 550-557.
24. Tesmer JJ,. 2009. Structure and function of regulator of G protein signaling homology domains. Prog Mol Biol Transl Sci 86: 75-113.
25. Traver S, Splingard A, Gaudriault G, De Gunzburg J,. 2004. The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling. Biochem J 379: 627-632.
26. Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR,. 2011. Activation of the regulator of G protein signaling 14-Galphai1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Biochemistry 50: 752-762.
27. Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP,. 2009. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PLoS ONE 4: e4884.
28. Zhao P, Nguyen CH, Chidiac P,. 2010. The proline-rich N-terminal domain of G18 exhibits a novel G protein regulatory function. J Biol Chem 285: 9008-9017.