Acute isoniazid intoxication: An uncommon cause of convulsion, coma and acidosis;Akut izoniazid intoksikasyonu: Konvülziyon, koma ve asidozun nadir bir nedeni

Tuberkuloz ve Toraks

Volumn 61, Issue 1, 2013, Pages 50-53

  Uzman, Sinan ^a   Uludaǧ Yanaral, Tümay ^a   Toptaş, Mehmet ^a   Koç, Alparslan ^a   Taş, Aytül ^a   Bican, Gülşen ^a  

^a HASEKI EDUCATION AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Acute isoniazid intoxication; Coma; Convulsions; Metabolic acidosis; Pyridoxine

Indexed keywords

ACTIVATED CARBON; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BICARBONATE; DIAZEPAM; ISONIAZID; LACTATE DEHYDROGENASE; PYRIDOXINE; RIFAMPICIN;

ACUTE ISONIAZID INTOXICATION; ADULT; ALCOHOL CONSUMPTION; ANION GAP; ARTICLE; BLOOD GAS ANALYSIS; CASE REPORT; CATHETER; COMA; CONVULSION; DRUG INTOXICATION; HUMAN; MALE; METABOLIC ACIDOSIS; NAUSEA AND VOMITING; SEIZURE; STOMACH LAVAGE; SUICIDE ATTEMPT; TUBERCULOSIS; UNCONSCIOUSNESS;

ACIDOSIS; ANTITUBERCULAR AGENTS; COMA; HUMANS; INFUSIONS, INTRAVENOUS; ISONIAZID; MALE; PYRIDOXINE; SEIZURES; SUICIDE, ATTEMPTED; TREATMENT OUTCOME; TURKEY; YOUNG ADULT;

EID: 84876195939     PISSN: 04941373     EISSN: None     Source Type: Journal    
DOI: 10.5578/tt.1897     Document Type: Article

References (17)

1. nd ed. Philadelphia: Saunders, 1990: 970-5.
2. Romero JA, Kuczler FJ. Isoniazid overdose. Recognition and management. Am Fam Physician 1998; 57: 749-52.
3. Cameron WM. Isoniazid overdose. Can Med Assoc J 1978; 118: 1413-5.
4. Sullivan EA, Geofffroy P, Weisman R, Hoffman R, Frieden TR. Isoniazid poisonings in New York City. J Emerg Med 1998; 16: 57-9.
5. De Lara ACF, Moral PGL, Cuison RJ. Isoniazid overdose at the Santo Tomas University Hospital-Clinical Division: a seven year review. Phil J Internal Med 1997; 35: 195-200.
6. Ozbay B, Sezgi C, Altinoz O, Sertogullarindan B, Tokgoz N. Evaluation of tuberculosis cases detected in our region between 1999 and 2003. Tuberk Toraks 2008; 56: 396-404.
7. Topcu I, Yentur EA, Kefi A, Ekici NZ, Sakarya M. Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. Anaesth Intensive Care 2005; 33: 518-20.
8. Nolan CM, Elarth AM, Barr HW. Intentional isoniazid overdo-sage in young Southeast Asian refugee women. Chest 1998; 93: 803-6.
9. Tai DY, Yeo JK, Eng PC, Wang YT. Intentional overdosage with isoniazid: case report and review of literature. Singapore Med J 1996; 37: 222-5.
10. Agrawal RL, Dwivedi NC, Agrawal M, Jain S, Agrawal A. Accidental isoniazid poisoning-a report. Indian J Tuberc 2008; 55: 94-6.
11. Tajender V, Saluja J. INH induced status epilepticus: response to pyridoxine. Indian J Chest Dis Allied Sci 2006; 48: 205-6.
12. Martinjak-Dvorsek I, Gorjup V, Horvat M, Noc M. Acute isoni-azid neurotoxicity during preventive therapy. Crit Care Med 2000; 28: 567-8.
13. Santucci KA, Shah BR, Linakis JG. Acute isoniazid exposures and antidote availability. Pediatr Emerg Care 1999; 15: 99-101.
14. Dattani RG, Harry F, Hutchings AD, Routledge PA. The effects of acute ethanol intake on isoniazid pharmacokinetics. Eur J Clin Pharmacol 2004; 60: 679-82.
15. Chin L, Sievers ML, Herrier RN, Picchioni AL. Potentiation of pyridoxine by depressants and anticonvulsants in the treatment of acute isoniazid intoxication in dogs. Toxicol Appl Pharmacol 1981; 58: 504-9.
16. Lovecchio F, Curry SC, Graeme KA, Wallace KL, Suchard J. Intravenous pyridoxine-induced metabolic acidosis. Ann Emerg Med 2001; 38: 62-4.
17. Panganiban LR, Makalinao IR, Corte-Maramba NP. Rhabdom-yolysis in isoniazid poisoning. J Toxicol Clin Toxicol 2001; 39: 143-51.