Sleep disorders as a cause of motor vehicle collisions

International Journal of Preventive Medicine

Volumn 4, Issue 3, 2013, Pages 246-257

  De Mello, Marco Túlio ^a,b   Narciso, Fernanda Veruska ^c   Tufik, Sergio ^a,c   Paiva, Teresa ^d   Spence, David Warren ^e   Bahammam, Ahmed S ^f   Verster, Joris C ^g,h   Pandi Perumal, Seithikurippu R ^f,i  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b Centro de Estudos em Psicobiologia e Exercício CEPE   (Brazil)

^c Clinical Microbiology Section   (Brazil)

^d CENC Lisbon Sleep Center   (Portugal)

^e not available   (Canada)

^f KING SAUD UNIVERSITY   (Saudi Arabia)

^g UTRECHT UNIVERSITY   (Netherlands)

^h SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

ⁱ SOMNOGEN CANADA INC   (Canada)

Author keywords

Alertness; Fatigue; Rest; Sleep; Traffic accident

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CAFFEINE; HYPNOTIC AGENT; MELATONIN; MODAFINIL; RAMELTEON; ZALEPLON; ZOLPIDEM; ZOPICLONE;

ACTIMETRY; ALERTNESS; AUSTRALIA; BEDTIME DOSAGE; BRAZIL; DIAGNOSTIC ACCURACY; DRIVER; DRIVING ABILITY; DRUG SAFETY; DRUNKEN DRIVING; EDUCATION PROGRAM; EXERCISE; FATIGUE; HUMAN; HYPERSOMNIA; INSOMNIA; NARCOLEPSY; OCULOGRAPHY; PHOTOTHERAPY; POLYSOMNOGRAPHY; POSITIVE END EXPIRATORY PRESSURE; PREVALENCE; RESTLESS LEGS SYNDROME; REVIEW; SIDE EFFECT; SLEEP DEPRIVATION; SLEEP DISORDER; SLEEP DISORDERED BREATHING; SOMNOLENCE; THERAPY EFFECT; TRAFFIC ACCIDENT; TRAFFIC SAFETY; UNITED KINGDOM; WAKEFULNESS; WORKLOAD;

EID: 84876195571     PISSN: 20087802     EISSN: 20088213     Source Type: Journal    
DOI: None     Document Type: Review

References (116)

1. Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet 1999;354:1435-9.
2. Mullington JM, Chan JL, Van Dongen HP, Szuba MP, Samaras J, Price NJ, et al. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. J Neuroendocrinol 2003;15:851-4.
3. Aldabal L, Bahammam AS. Metabolic, endocrine, and immune consequences of sleep deprivation. Open Respir Med J 2011;5:31-43.
4. Ayas NT, White DP, Al-Delaimy WK, Manson JE, Stampfer MJ, Speizer FE, et al. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care 2003;26:380-4.
5. Spiegel K, Knutson K, Leproult R, Tasali E, Van Cauter E. Sleep loss: A novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol 2005;99:2008-19.
6. Ayas NT, White DP, Manson JE, Stampfer MJ, Speizer FE, Malhotra A, et al. A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med 2003;163:205-9.
7. Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry 2002;59:131-6.
8. Liu Y, Tanaka H; Fukuoka Heart Study Group. Overtime work, insufficient sleep and risk of non-fatal acute myocardial infarction in Japanese men. Occup Environ Med 2002;59:447-51.
9. Howard ME, Desai AV, Grunstein RR, Hukins C, Armstrong JG, Joffe D, et al. Sleepiness, sleep-disordered breathing, and accident risk factors in commercial vehicle drivers. Am J Respir Crit Care Med 2004;170:1014-21.
10. Pandi-Perumal SR, Verster J., Kayumov L, Lowe AD, Santana MG, Pires ML, et al. Sleep disorders, sleepiness and traffic safety: A public health menace. Braz J Med Biol Res 2006;39:863-71.
11. Philip P. Sleepiness of Occupational Driver. Ind Health 2005;43:30-3.
12. Crummy F, Cameron PA, Swann P, Kossmann T, Naughton MT. Prevalence of sleepiness in surviving drivers of motor vehicle collisions. Intern Med J 2008;38:769-75.
13. Philip P, Sagaspe P, Moore N, Taillard J, Charles A, Guilleminault C, et al. Fatigue, sleep restriction and driving performance. Accid Anal Prev 2005;37:473-8.
14. Nabi H, Guéguen A, Chiron M, Lafont S, Zins M, Lagarde E. Awareness of driving while sleepy and road traffic accidents: Prospective study in GAZEL cohort. Research. BMJ 2006;333:75.
15. Vanlaar W, Simpson H, Mayhew D, Robertson R. Fatigued and drowsy driving: A survey of attitudes, opinions and behaviors. J Safety Res 2008;39:303-9.
16. Tregear S, Reston J, Schoelles K, Phillips B. Obstructive sleep apnea and risk of motor vehicle crash: Systematic review and meta-analysis. J Clin Sleep Med 2009;5:573-81.
17. Vakulin A, Baulk SD, Catcheside PG, Antic NA, van den Heuvel CJ, Dorrian J, et al. Effects of alcohol and sleep restriction on simulated driving performance in untreated patients with obstructive sleep apnea. Ann Intern Med 2009;151:447-55.
18. Rodenstein D. Sleep apnea: Traffic and occupational accidents--individual risks, socioeconomic and legal implications. Respiration 2009;78:241-8.
19. Philip P, Sagaspe P, Lagarde E, Leger D, Ohayon MM, Bioulac B, et al. Sleep disorders and accidental risk in a large group of regular registered highway drivers. Sleep Med 2010;11:973-9.
20. Horne JA, Reyner LA. Driver sleepiness. J Sleep Res 1995;4:23-9.
21. Driver fatigue and road accidents: A literature review and position paper. ROSPA; February 2001. Available from: http://www.rospa.com/roadsafety/info/fatigue.pdf [Last accessed on 2012 Feb 06].
22. World Health Organization (WHO), 2010. Global Plan for the Decade of Action for Road Safety 2011-2020, WHO, Geneva. Avaiable from: http://www.roadsafetyfund.org/UnDecadeOfAction/Documents/global-plan-en.pdf [Last accessed on 2012 Feb 06].
23. World Health Organization (WHO), 2009. Global status report on road safety time for action, WHO, Geneva. Avaiable from: http://www.whqlibdoc.who.int/publications/2009/9789241563840-eng.pdf [Last accessed on 2012 Feb 06].
24. Bundesanstalt für StraBenwesen-BASt: Federal Highway Research Institute. Available from: http://www.bast.de/nn-76784/EN/e-Statistik/e-Unfalldaten-Downloads/e-getoetete-gesamt-ortslage,templateId=raw,property=publicationFile.pdf/e-getoetete-gesamt-ortslage.pdf [Last accessed on 2012 Feb 06].
25. Dead and injured in road traffic accidents by province. Country's total. Years: 2004-8. National Institute of Statistics and Census-INDEC. Avaiable from: http://www.indec.gov.ar/nuevaweb/cuadros/8/c030603.xls [Last accessed on 2012 Feb 06].
26. Sehat M, Naieni KH, Asadi-Lari M, Foroushani AR, Malek-Afzali H. Socioeconomic status and incidence of traffic accidents in metropolitan tehran: A populationbased study. Int J Prev Med 2012;3:181-90.
27. Statistical Yearbook of the Federal Highway 2009: Traffic Accidents and Actions to Combat Crime. National Department of Transport Infrastructure /The Brazilian Federal Highway Police; 2009. Available from: http://www.dnit.gov.br/rodovias/operacoes-rodoviarias/estatisticas-de-acidentes/anuario-2009.pdf [Last accessed on 2012 Feb 06].
28. Smolensky MH, Di Milia L, Ohayon MM, Philip P. Sleep disorders, medical conditions, and road accident risk. Accid Anal Prev 2011;43:533-48.
29. Verster J., Taillard J, Sagaspe P, Olivier B, Philip P. Prolonged nocturnal driving can be as dangerous as severe alcohol-impaired driving. J Sleep Res 2011;20:585-8.
30. Alonderis A, Barbe F, Bonsignore M, Calverley P, De Backer W, Diefenbach K, et al. Medico-legal implications of sleep apnoea syndrome: Driving license regulations in Europe. Sleep Med 2008;9:362-75.
31. de Mello MT, Bittencourt LR, Cunha Rde C, Esteves AM, Tufik S. Sleep and transit in Brazil: New legislation. J Clin Sleep Med 2009;5:164-6.
32. An Analysis of the Significant Decline in Motor Vehicle Traffic Fatalities in 2008. NHTSA; 2010. Available from: http://www-nrd.nhtsa.dot.gov/Pubs/811346.pdf [Last accessed on 2012 Feb 06].
33. Road safety Information: Driver fatigue and road accidents. ROSPA; 2011. Available from: http://www.rospa.com/roadsafety/info/driver-fatigue-2011.pdf [Last accessed on 2012 Feb 06].
34. Heavy vehicle driver fatigue final regulatory impact statement. National Transport Comission-NTC Australia. Available from: http://www.ntc.gov.au/filemedia/Reports/3HVDFHVDFRISFeb2007.pdf [Last accessed on 2012 Feb 06].
35. Road crash facts for South Australia. Government of South Australia/Department for transport, energy and Infrastructure. Available from: http://www.transport.sa.gov.au/pdfs/safety/road-crash/Crash-Facts.pdf [Last accessed on 2012 Feb 06].
36. Tefft B. Asleep at the Wheel: The Prevalence and Impact of Drowsy Driving. In: AAA Foundation for Traffic Safety. Washington, D.C., 2010.
37. Statistics Operations. The Brazilian Federal Highway Police. Avaiable from: http://www.dprf.gov.br/PortalInternet/estatistica.faces [Last accessed on 2012 Feb 06].
38. Souza JC, Paiva T, Reimao R. Sleep habits, sleepiness and accidents among truck drivers. Arq Neuropsiquiatr 2005;63:925-30.
39. da Silva-Junior FP, de Pinho RS, de Mello MT, de Bruin VM, de Bruin PF. Risk factors for depression in truck drivers. Soc Psychiat Psychiat Epidem 2009;44:125-9.
40. Dawson D, Reid K. Fatigue, alcohol and performance impairment. Nature 1997;388:235-7.
41. Williamson AM, Feyer AM. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occup Environ Med 2000;57:649-55.
42. Sagaspe P, Taillard J, Bayon V, Lagarde E, Moore N, Boussuge J, et al. Sleepiness, near-misses and driving accidents among a representative population of French drivers. J Sleep Res 2010;19:578-84.
43. Komada Y, Nishida Y, Namba K, Abe T, Tsuiki S, Inoue Y. Elevated risk of motor vehicle accident for male drivers with obstructive sleep apnea syndrome in the Tokyo metropolitan area. Tohoku J Exp Med 2009;219:11-6.
44. Amra B, Dorali R, Mortazavi S, Golshan M, Farajzadegan Z, Fietze I, et al. Sleep apnea symptoms and accident risk factors in Persian commercial vehicle drivers. Sleep Breath 2012;187-91.
45. George CF. Sleep apnea, alertness, and motor vehicle crashes. Am J Respir Crit Care Med 2007;176:954-6.
46. Shiomi T, Arita AT, Sasanabe R, Banno K, Yamakawa H, Hasegawa R, et al. Falling asleep while driving and automobile accidents among patients with obstructive sleep apnea-hypopnea syndrome. Psychiatry Clin Neurosci 2002;56:333-4.
47. Hack M. Obstructive sleep apnoea: Accidents waiting to happen. Airways J 2004;2:37-8. Available from: http://www.welshsas.org/documents/AJ-Mar-37-38.pdf [Last accessed on 2012 Feb 06].
48. Prilipko O, Huynh N, Schwartz S, Tantrakul V, Kim JH, Peralta AR, et al. Task positive and default mode networks during a parametric working memory task in obstructive sleep apnea patients and healthy controls. Sleep 2011;34:293-301A.
49. Mulgrew AT, Nasvadi G, Butt A, Cheema R, Fox N, Fleetham JA, et al. Risk and severity of motor vehicle crashes in patients with obstructive sleep apnoea/ hypopnoea. ThoraX2008;63:536-41.
50. Vakulin A, Baulk SD, Catcheside PG, Antic NA, van den Heuvel CJ, Dorrian J, et al. Driving simulator performance remains impaired in patients with severe OSA after CPAP treatment. J Clin Sleep Med 2011;7:246-53.
51. Vennelle M, Engleman HM, Douglas NJ. Sleepiness and sleep-related accidents in commercial bus drivers. Sleep Breath 2010;14:39-42.
52. Tippin J, Sparks J, Rizzo M. Visual vigilance in drivers with obstructive sleep apnea. J Psychosom Res 2009;67:143-51.
53. Powell NB, Schechtman KB, Riley RW, Guilleminault C, Chiang RP, Weaver EM. Sleepy driver near-misses may predict accident risks. Sleep 2007;30:331-42.
54. Donjacour CE, Mets AJ, Verster JC. Driving and Traffic Safety. In Narcolepsy: A Clinical guide. Goswami M, Pandi-Perumal SR, Thorpy MJ, editors. Springer Science, New York, USA; 2010. http://link.springer.com/chapter/10.1007/978-1-4419-0854-4-19 [Last accessed on 2012 Feb 06].
55. Pérez-Chada D, Videla AJ, O'Flaherty ME, Palermo P, Meoni J, Sarchi MIx, /xetalet al/etal. Sleep habits and accident risk among truck drivers: A cross-sectional study in Argentina. Sleep 2005;28:1103-8.
56. Hakkanen H, Summala H. Sleepiness at Work Among Commercial Truck Drivers. Sleep 2000;23:49-57.
57. de Pinho RS, da Silva-Junior FP, Bastos JP, Maia WS, de Mello MT, de Bruin VM et al. Hypersomnolence and accidents in truck drivers: A cross-sectional study. Chronobiol Int 2006;23:963-71.
58. de Mello MT, Esteves AM, Pires ML, Santos DC, Bittencourt LR, Silva RS, et al. Relationship between Brazilian airline pilot errors and time of day. Braz J Med Biol Res 2008;41:1129-31.
59. Aguiar M, Valenca J, Felizardo M, Caeiro F, Moreira S, Staats R, et al. Obstructive sleep apnoea syndrome as a cause of road traffic accidents. Rev Port Pneumol 2009;15:419-31.
60. Krieger J. Sleep apnoea and driving: How can this be dealt with? Eur Respir Rev 2007;16:189-95.
61. The Brazilian Health Surveillance Secretariat/Ministry of Health of Brazil. Available from: http://www.datasus.gov.br. [Last accessed on 2008].
62. Leger D, Massuel MA, Metlaine A; SISYPHE Study Group. Professional correlates of insomnia. Sleep 2006;29:171-8.
63. Daley M, Morin CM, LeBlanc M, Gregoire JP, Savard J, Baillargeon L. Insomnia and its relationship to health-care utilization, work absenteeism, productivity and accidents. Sleep Med 2009;10:427-38.
64. Williamson A, Lombardi DA, Folkard S, Stutts J, Courtney TK, Connor JL. The link between fatigue and safety. Accid Anal Prev 2011;43:498-515.
65. Verster J., Roth T. The prevalence and nature of stopped on-the-road driving tests and the relationship with objective performance impairment. Accid Anal Prev 2012;45:498-506.
66. Verster J., Roth T. Standard operation procedures for conducting the on-the-road driving test, and measurement of the standard deviation of lateral position (SDLP). Int J Gen Med 2011;4:359-71.
67. Mets MA, Ketzer S, Blom C, van Gerven MH, van Willigenburg GM, Olivier B, et al. Positive effects of Red Bull (R) Energy Drink on driving performance during prolonged driving. Psychopharmacology (Berl) 2011;214:737-45.
68. Mets M, Baas D, van Boven I, Olivier B, Verster J. Effects of coffee on driving performance during prolonged simulated highway driving. Psychopharmacology (Berl) 2012;222:337-42.
69. Verster J., Veldhuijzen DS, Volkerts ER. Residual effects of sleep medication on driving ability. Sleep Med Rev 2004;8:309-25.
70. Verster J., Veldhuijzen DS, Patat A, Olivier B, Volkerts ER. Hypnotics and driving safety: Meta-analyses of randomized controlled trials applying the on-the-road driving test. Curr Drug Saf 2006;1:63-71.
71. Verster J., Spence DW, Shahid A, Pandi-Perumal SR, Roth T. Zopiclone as positive control in studies examining the residual effects of hypnotic drugs on driving ability. Curr Drug Saf 2011;6:209-18.
72. Mets MA, de Vries JM, de Senerpont Domis LM, Volkerts ER, Olivier B, Verster JC. Next-day effects of ramelteon (8 mg), zopiclone (7.5 mg), and placebo on highway driving performance, memory functioning, psychomotor performance, and mood in healthy adult subjects. Sleep 2011;34:1327-34.
73. Barbone F, McMahon AD, Davey PG, Morris AD, Reid IC, McDevitt DG, et al. Association of road-traffic accidents with benzodiazepine use. Lancet 1998;352:1331-6.
74. Johns M, Tucker A, Chapman R, Crowley K, Michael N. Monitoring eye and eyelid movements by infrared reflectance oculography to measure drowsiness in drivers. Somnologie 2007;11:234-42. The manuscript is available from http://www.mwjohns.com/wp-content/uploads/2009/murray-papers/johns-et-al-2007-monitoring-eye-and-eyelid-movements-by-ir- reflectance-oculography-to-measure-drowsiness-in-drivers.pdf [Last accessed on 2012 Feb 06].
75. Johns M, Chapman R, Crowley K, Tucker A. A new method for assessing the risks of drowsiness while driving. Somnologie 2008;12:66-74. The manuscript is available from http://www.mwjohns.com/wp-content/uploads/2009/murray-papers/johns-et-al-2008-a-new-method-for-assessing-the-risks-of-drowsiness-while-driving.pdf [Last accessed on 2012 Feb 06].
76. rd, Monk TH, Berman SR, Kupfer DJ. The pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193-213.
77. Carskadon MA, Dement WC, Mitler MM, Roth T, Westbrook PR, Keenan S. Guidelines for the multiple sleep latency test (MSLT): A standard measure of sleepiness. Sleep 1986;9:519-24.
78. Zwyghuizen-Doorenbos A, Roehrs T, Schaefer M, Roth T. Test-retest reliability of the MSLT. Sleep 1988;11:562-5.
79. Mathis J, Hess CW. Sleepiness and vigilance tests. Swiss Med Wkly 2009;139:214-9.
80. Bennett LS, Stradling JR, Davies RJ. A behavioural test to assess daytime sleepiness in obstructive sleep apnoea. J Sleep Res 1997;6:142-5.
81. Mitler MM, Gujavarty KS, Browman CP. Maintenance of wakefulness test: A polysomnographic technique for evaluation treatment efficacy in patients with excessive somnolence. Electroencephalogr Clin Neurophysiol 1982;53:658-61.
82. Wilhelm B, Giedke H, Ludtke H, Bittner E, Hofmann A, Wilhelm H. Daytime variations in central nervous system activation measured by a pupillographic sleepiness test. J Sleep Res 2001;10:1-7.
83. Balkin TJ, Bliese PD, Belenky G, Sing H, Thorne DR, Thomas M, et al. Comparative utility of instruments for monitoring sleepiness-related performance decrements in the operational environment. J Sleep Res 2004;13:219-27.
84. Sack RL, Auckley D, Auger RR, Carskadon MA, Wright KP Jr, Vitiello MV, et al. Circadian rhythm sleep disorders: Part I, basic principles, shift work and jet lag disorders. An American academy of sleep medicine review. Sleep 2007;30:1460-83.
85. Iber C, Ancoli-Israel S, Chesson Jr. A, Quan S, Thomas M. The AASM manual for the scoring of sleep and associated events: Rules, terminology and technical specifications. Westchester: American Academy of Sleep Medicine; 2007. p. 2-59.
86. Morgenthaler TI, Lee-Chiong T, Alessi C, Friedman L, Aurora RN, Boehlecke B, et al. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American academy of sleep medicine. Report Standards Of Practice Committee Of The AASM. Sleep 2007;30:1445-59.
87. Sack RL, Auckley D, Auger RR, Carskadon MA, Wright KP Jr, Vitiello MV, et al. Circadian rhythm sleep disorders: Part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review. Sleep 2007;30:1484-501.
88. Sassani A, Findley LJ, Kryger M, Goldlust E, George C, Davidson TM. Reducing motor-vehicle collisions, costs, and fatalities by treating obstructive sleep apnea syndrome. Sleep 2004;27:453-8.
89. Hartenbaum N, Collop N, Rosen IM, Phillips B, George CF, Rowley JA, et al. Sleep apnea and commercial motor vehicle operators: Statement from the joint task force of the American college of chest physicians, the American college of occupational and environmental medicine, and the national sleep foundation. Chest 2006;130:902-5.
90. Rodenstein D; Cost-B26 Action on Sleep Apnoea Syndrome. Driving in Europe: The need of a common policy for drivers with obstructive sleep apnoea syndrome. J Sleep Res 2008;17:281-4.
91. Stepanski EJ, Wyatt JK. Use of sleep hygiene in the treatment of insomnia. Sleep Med Rev 2003;7:215-25.
92. Tufik S. I Consenso Brasileiro de Insônia. Hypnos 2003;3-45. http://www.ic.unicamp.br/~wainer/cursos/2s2008/ia/pdf-consenso.pdf [Last accessed on 2012 Feb 06].
93. Crispim CA, Zalcman I, Dattilo M, Padilha HG, Edwards B, Waterhouse J. et al. The influence of sleep and sleep loss upon food intake and metabolism. Nutr Res Rev 2007;20:195-212.
94. Crispim C, Zalcman I, Dattilo M, Padilha H, Tufik S, Mello M. Shift work and nutritional aspects. A review. Nutrire 2009;34:213-27. Available from: http://www.files.bvs.br/upload/S/1519-8928/2009/v34n2/a213-227.pdf [Last accessed on 2012 Feb 06].
95. Youngstedt SD. Effects of exercise on sleep. Clin Sports Med 2005;24:355-65.
96. Antunes H, Andersen M, Tufik S, Mello M. Privação de Sono e Exercício Físico. Rev Bras Med Esporte 2008;14:51-6. http://www.scielo.br/pdf/rbme/v14n1/a10v14n1.pdf [Last accessed on 2012 Feb 06].
97. Takahashi M. The role of prescribed napping in sleep medicine. Sleep Med Rev 2003;7:227-35.
98. Sagaspe P, Taillard J, Chaumet G, Moore N, Bioulac B, Philip P. Aging and nocturnal driving: Better with coffee or a nap? A randomized study. Sleep 2007;30:1808-13.
99. Gooley JJ. Treatment of circadian rhythm sleep disorders with light. Ann Acad Med 2008;37:669-76.
100. Purnell MT, Feyer AM, Herbison GP. The impact of a nap opportunity during the night shift on the performance and alertness of 12-h shift workers. J Sleep Res 2002;11:219-27.
101. Lahl O, Wispel C, Willigens B, Pietrowsky R. An ultra short episode of sleep is sufficient to promote declarative memory performance. J Sleep Res 2008;17:3-10.
102. Reyner LA, Horne JA. Early morning driver sleepiness: Effectiveness of 200 mg caffeine. Psychophysiology 2000;37:251-6.
103. Asaoka S, Abe T, Komada Y, Inoue Y. The factors associated with preferences for napping and drinking coffee as countermeasures for sleepiness at the wheel among Japanese drivers. Sleep Med 2012;13:354-61.
104. National Sleep Foundation (NSF). Sleep Studies. Available from: http://www.sleepfoundation.org/article/sleep-topics/sleep-studies [Last accessed on 2012 Feb 06].
105. NSF. Fatigue and Excessive Sleepiness. Available from: http://www.sleepfoundation.org/article/sleep-related-problems/excessive-sleepiness-and-sleep [Last accessed on 2012 Feb 06].
106. NSF. Sleep Drive and Your Body Clock. Available from: http://www.sleepfoundation.org/article/sleep-topics/sleep-drive-and-your-body-clock [Last accessed on 2012 Feb 06].
107. NSF. Let Sleep Work for You. Available from: http://www.sleepfoundation.org/article/hot-topics/let-sleep-work-you [Last accessed on 2012 Feb 06].
108. Rial RV, Nicolau MC, Gamundi A, Akaarir M, Aparicio S, Garau C, et al. The trivial function of sleep. Sleep Med Rev 2007;11:311-25.
109. Davies KA, Macfarlane GJ, Nicholl BI, Dickens C, Morriss R, Ray D, et al. Restorative sleep predicts the resolution of chronic widespread pain: Results from the EPIFUND study. Rheumatology (Oxford) 2008;47:1809-13.
110. Samuels C. Sleep, recovery, and performance: The new frontier in high-performance athletics. Phys Med Rehabil Clin N Am 2009;20:149-59.
111. Oluwole OS. Sleep habits in Nigerian undergraduates. Acta Neurol Scand 2010;121:1-6.
112. Abe T, Komada Y, Nishida Y, Hayashida K, Inoue Y. Short sleep duration and long spells of driving are associated with the occurrence of Japanese drivers' rear-end collisions and single-car accidents. J Sleep Res 2010;19:310-6.
113. Holmdahl C, Schollin IL, Alton M, Nilsson K. CPAP treatment in obstructive sleep apnoea: A randomised, controlled trial of follow-up with a focus on patient satisfaction. Sleep Med 2009;10:869-74.
114. McDaid C, Griffin S, Weatherly H, Durée K, van der Burgt M, van Hout S, et al. Continuous positive airway pressure devices for the treatment of obstructive sleep apnoea-hypopnoea syndrome: A systematic review and economic analysis. Health Technol Assess 2009;13:1-119.
115. Yamamoto H, Akashiba T, Kosaka N, Ito D, Horie T. Long-term effects nasal continuous positive airway pressure on daytime sleepiness, mood and traffic accidents in patients with obstructive sleep apnoea. Respir Med 2000;94:87-90.
116. Barbé F, Sunyer J, De La Peña A, Pericas J, Mayoralas LR, Antó JM, et al. Effect of Continuous Positive Airway Pressure on the Risk of Road Accidents in Sleep Apnea Patients. Respiration 2007;74:44-9.