Mitogen-activated protein kinases regulate vascular reactivity after hemorrhagic shock through myosin light chain phosphorylation pathway

Journal of Trauma and Acute Care Surgery

Volumn 74, Issue 4, 2013, Pages 1033-1043

  Yang, Guangming ^a   Li, Tao ^a   Xu, Jing ^a   Peng, Xiaoyong ^a   Liu, Liangming ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

ERK; hemorrhagic shock; p38 MAPK; rats; Vascular reactivity

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANGIOTENSIN II; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALCIUM; INTEGRIN LINKED KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MYOSIN LIGHT CHAIN PHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; BLOOD VESSEL REACTIVITY; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYMATIC ASSAY; ENZYME ACTIVITY; FEMALE; HEMORRHAGIC SHOCK; HYPOXIA; LAPAROTOMY; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SUPERIOR MESENTERIC ARTERY; VASCULAR SMOOTH MUSCLE;

ANIMALS; BLOOD VESSELS; DISEASE MODELS, ANIMAL; FEMALE; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOSIN LIGHT CHAINS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC; VASOCONSTRICTION;

EID: 84876174166     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31828586a2     Document Type: Article

References (26)

1. Hasan A, McDonough KH. The effects of Escherichia coli sepsis and short-term ischemia on coronary vascular reactivity and myocardial function. Shock. 1997;8:305-310.
2. Li T, Fang YQ, Yang GM, Xu J, Zhu Y, Liu LM. Effects of the balance in activity of RhoA and Rac1 on the shock-induced biphasic change of vascular reactivity in rats. Ann Surg. 2011;253:185-193.
3. Hausenloy DJ, Yellon DM. Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc Res. 2006;70:240-253.
4. Hoefer J, Azam MA, Kroetsch JT, Leong PH, Momen MA, Voigtlaender BJ, Scherer EQ, Meissner A, Bolz SS, Husain M. Sphingosine-1-hosphateYdependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. Circ Res. 2010;107:923-933.
5. Matsumoto T, Kakmi M, Kobayashi T, Kamata K. Gender differences in vascular reactivity to endothelin-1(1-31) in mesenteric arteries from diabetic mice. Peptides. 2008;29:1338-1346.
6. Heidbreder M, Naumann A, Tempel K, Dominiak P, Dendorfer A. Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways. Cardiovasc Res. 2008;78:108-115.
7. Touyz RM, El Mabrouk M, He G, Wu XH, Schiffrin EL. Mitogen-activated protein/extracellular signal-regulated kinase inhibition attenuates angiotensin IIYmediated signaling and contraction in spontaneously hypertensive rat vascular smooth muscle cells. Circ Res. 1999;84:505-515.
8. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, et al. Calcium sensiti-zation of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997;389:990-994.
9. 2+ sensitization in rat ileal longitudinal smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2007;293:G699-G710.
10. Kitazawa T, Masuo M, Somlyo AP. G proteinYmediated inhibition of myosin light-chain phosphatase in vascular smooth muscle. Proc Natl Acad Sci USA. 1991;88:9307-9310.
11. 2+ sensitization via myosin phosphatase inhibition. J Biol Chem. 2002; 277:23441-23446.
12. Klingenberg D, Gunduz D, Hartel F, Bindewald K, Schäfer M, Piper HM, Noll T. MEK/MAPK as a signaling element in ATP control of endothelial myosin light chain. Am J Physiol Cell Physiol. 2004;286:C807-C812.
13. Yang GM, Li T, Xu J, Liu LM. PKC plays an important mediated effect in arginine vasopressin induced restoration of vascular responsiveness and calcium sensitization following hemorrhagic shock in rats. Eur J Pharmacol. 2010;628:148-154.
14. Xu J, Yang GM, Li T, Ming J, Liu LM. Involvement of Cpi-17 and zipper-interacting protein kinase in the regulation of protein kinase C-alpha, protein kinase C-epsilon on vascular calcium sensitivity after hemorrhagic shock. Shock. 2010;33:49-55.
15. Li T, Liu LM, Xu J, Yang GM, Ming J. Changes of Rho kinase activity after hemorrhagic shock and its role in shock-induced biphasic response of vascular reactivity and calcium sensitivity. Shock. 2006;26:504-509.
16. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
17. 20 phosphorylation pathway. J Surg Res. 2010;161:312-320.
18. 2+-independent myosin diphosphorylation and contraction of vascular smooth muscle. Biochem J. 2005;392:641-648.
19. Graves PR, Winkfield KM, Haystead TA. Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation. J Biol Chem. 2005;280:9363-9374.
20. Ming J, Li T, Zhang Y, Xu J, Yang GM, Liu LM. Regulatory effects of myoendothelial gap junction on vascular reactivity after hemorrhagic shock in rats. Shock. 2009;31:80-86.
21. Xu J, Liu LM. The role of calcium desensitization in vascular hyporeactivity and its regulation after hemorrhagic shock in the rat. Shock. 2005;23:576-581.
22. Hartshorne DJ, Ito M, Erdodi F. Myosin light chain phosphatase: subunit composition, interactions and regulation. J Muscle Res Cell Motil. 1998;19:325-341.
23. Liu LM, Ward JA, Dubick MA. Hemorrhage-induced vascular hyporeactivity to norepinephrine in select vasculatures of rats and the roles of nitric oxide and endothelin. Shock. 2003;19:208-214.
24. Li S, Fan SX, McKenna TM. Role of nitric oxide in sepsis-induced hyporeactivity in isolated rat lungs. Shock. 1996;5:122-129.
25. Marechal X, Favory R, Joulin O, et al. Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stress. Shock. 2008;29:572-576.
26. Spain DA, Wilson MA, Krysztopik RJ, et al. Differential intestinal mi-crovascular dysfunction occurs during bacteremia. J Surg Res. 1997; 67:67-71.