Rat brain-uptake index for phenylethylamine and various monomethylated derivatives

Neurochemical Research

Volumn 38, Issue 4, 2013, Pages 842-846

  Mosnaim, Aron D ^a   Callaghan, Owen H ^b   Hudzik, Thomas ^c   Wolf, Marion E ^d  

^a Univ of Medicine and Science   (United States)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^c ABBVIE INC   (United States)

^d International Neuropsychiatry Consultants   (United States)

Author keywords

Amphetamine; Blood brain barrier; Brain uptake index; Monomethylated phenylethylamine derivatives; Phenylethylamine

Indexed keywords

4 METHYLPHENYLETHYLAMINE; AMPHETAMINE; BETA METHYLPHENYLETHYLAMINE; CARBON 14; PHENETHYLAMINE; PHENETHYLAMINE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; FRONTAL CORTEX; GAS CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMPHETAMINE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; MALE; METHAMPHETAMINE; PHENETHYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; TRITIUM;

RATTUS;

EID: 84876173126     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-0988-1     Document Type: Article

References (38)

1. Shulgin A, Shulgin A (1991) Phenethylamines I have known and loved: a chemical love story. Transform Press, Berkeley
2. Berry MD (2004) Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. J Neurochem 90:257-271 (Pubitemid 38938212)
3. Mosnaim AD, Wolf ME (eds) (1978) Non-catecholic Phenylethylamines. Part 1: phenylethylamine: biological mechanisms and clinical aspects. Marcel Dekker, New York
4. Chevesich JA, Callaghan OH, Wolf ME, Mosnaim AD (1983) Behavioral effects in mice produced by monosubstituted phenylethylamines. Fed Proceedings 733-734
5. www.healthremedies.com. Accessed 2012, Copyrights 2008-2012
6. Lindemann L, Hoener MC (2005) A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol Sci 26(5):274-281. http://www.ncbi.nlm.nih. gov/pubmed/15860375 (Pubitemid 40603076)
7. Borowsky B, Adham N, Jones KA, Raddaz R, Artymyshyn R, Ogozalek KL et al (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA 98:8966-8971 (Pubitemid 32743853)
8. Bunzow JR, Sonders MS, Arttamangkul S et al (2001) Amphetamine, 3,4 methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 60:1181-1188 (Pubitemid 33144888)
9. Parker EM, Cubeddu LX (1988) Comparative effects of amphetamine, phenylethylamine and related drugs on dopamine efflux, dopamine uptake and mazindol binding. J Pharmacol Exp Ther 245:199-210
10. Shannon and DeGregorio (1982) Self administration of the endogenous trace amines beta-phenethylamine, N-methyl-phenethylamine and phenylethanolamine in dogs. J Pharmacol Exp Ther 222:52-60
11. Oldendorf WH (1970) Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard. Brain Res 24:1629-1639
12. Mosnaim AD, Callaghan OH, Wolf ME (1981) Determination of non-catecholic phenylethylamines and monomethylated derivatives of phenylethylamines. J Chromatogr Biomed Appl 224:481-487 (Pubitemid 12225770)
13. Ambikanandan M, Ganesh S, Aliasgar A, Shrenik PS (2003) Drug delivery to the central nervous system: a review. J Pharm Pharm Sci 6(2):252-273 (Pubitemid 37207232)
14. Mosnaim AD, Karoum F, Zeller A, Callaghan OH, Singh SP, Wolf ME (1982) Platelet monoamine oxidase activity and plasma levels of non-catecholic phenylethylamines in insulin-dependent diabetic subjects. Clin Chim Acta 126:237-242 (Pubitemid 13209484)
15. Fischer EE, Heller BB, Miro AH (1968) Beta-phenylethylamine in human urine. Arzneimittelforschung 18(11):1486
16. Inwang EE, Mosnaim AD, Sabelli HC (1973) Isolation and characterization of phenylethylamine and phenylethanolamine from human brain. J Neurochem 20:1469-1473
17. Saavedra JM (1974) Enzymatic isotopic assay for and presence of Β-phenylethylamine in brain. J Neurochem 22:211-216
18. Karoum F, Nasrallah H, Potkin S, Chuang L, Moyer-Schwing J, Phillips I, Wyatt RJ (1979) Mass fragmentography of phenylethylamine, m- and p-tyramine and related amines in plasma, cerebrospinal fluid, urine, and brain. J Neurochem 33(1):201-212 (Pubitemid 9233926)
19. Mosnaim AD, Wolf ME (eds) (1978) Non-catecholic phenylethylamines. Part 2: phenylethanolamine, tyramines and octopamine. Marcel Dekker, USA
20. Hansen TR, Greenberg J, Mosnaim AD (1980) Direct effect of phenylethylamine upon isolated vascular smooth muscle of the rat. Eur J Pharmacol 63:95-101 (Pubitemid 10105499)
21. 3Hbeta- phenylethylamine binding sites in rat brain. Eur J Pharmacol 83:147-148 (Pubitemid 12019398)
22. Sabelli HC, Mosnaim AD (1974) Phenylethylamine hypothesis of affective behavior. Am J Psychiatr 131:695-699
23. Boulton AA (1980) Trace amines and mental disorders. Can J Neurol Sci 7:261-263 (Pubitemid 10052086)
24. Wolf ME, Mosnaim AD (1983) Phenylethylamine in neuropsychiatric disorders. Gen Pharmacol 14(4):385-390 (Pubitemid 13030382)
25. Sotnikova TD, Zorina OI, Ghisi V, Caron MG, Gainetdinov RR (2008) Trace amine associated receptor 1 and movement control. Parkinsonism Relat Disord 14(Suppl 2):S99-S102
26. Yang HYT, Neff NH (1973) B-Phenylethylamine: a specific substrate for type B monoamineoxidase in brain. J Pharm Exp Ther 187:365-371
27. Durden DA, Davis BA (1993) Determination of regional distribution of phenylethylamine and meta- and para-tyramine in rat brain regions and presence in human and dog plasma by an ultra-sensitive negative chemical ion gas chromatography-mass spectrometric (NCI-GC-MS) method. Neurochem Res 18:995-1002 (Pubitemid 23220475)
28. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (2001) Trace amines; identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA 98(16):8966-8971 (Pubitemid 32743853)
29. Maguire JJ, Barriocanal FP, Davenport AP (2002) Are vasoconstrictor responses to tyramine in human blood vessels, in vitro, mediated by the orphan trace amine receptor, TA1. Br J Pharmacol 131:71
30. Lewin AH (2006) Receptors of mammalian trace amines. AAPS J 8(1):E138-E145
31. Fehler M, Broadley KJ, Ford WR, Kidd EJ (2010) Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by β-phenylethylamine. Naunyn Schmiedebergs Arch Pharmacol 82(4):385-398
32. www.wada-ama.org World Anti-Doping Agency (Accessed 2012)
33. Sabelli HC, Vazquez AJ, Mosnaim AD, Madrid-Pedemonte L (1974) 2-Phenylethylamine as a possible mediator for 9-tetrahydrocannabinol-induced stimulation. Nature 248:144-145
34. Mosnaim AD, Wolf ME, Zeller EA (1984) Degradation kinetics by MAO of PEA derivatives. A model for the molecular basis of their analgesic and behavioral effects? In: Boulton A, Baker G, Dewhurst W, Sandler M (eds) Neurobiology of trace amines. Humana Press, New Jersey, pp 299-306
35. Davenport AP (2003) Peptide and trace amines orphan receptors: prospects for new therapeutic targets. Curr Opin Pharmacol 3:27-34 (Pubitemid 36131323)
36. Branchek TA, Blackburn TP (2003) Trace amines receptors as targets for novel therapeutics: legend, myth and fact. Curr Opin Pharmacol 3(1):90-97 (Pubitemid 36131333)
37. Berry MD (2007) The potential of trace amines and their receptors for treating neurological and psychiatric diseases. Rev Recent Clin Trials 2:3-19 (Pubitemid 46723183)
38. Xie Z, Miller GM (2008) Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain. J Pharmacol Exp Ther 325(2):617-628 (Pubitemid 351574814)