Lovastatin treatment mitigates the pro-inflammatory cytokine response in respiratory syncytial virus infected macrophage cells

Antiviral Research

Volumn 98, Issue 2, 2013, Pages 332-343

  Ravi, Laxmi Iyer ^a   Li, Liang ^b   Wong, Pui San ^c   Sutejo, Richard ^a   Tan, Boon Huan ^c   Sugrue, Richard J ^a,b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^c DSO NATIONAL LABORATORIES   (Singapore)

Author keywords

Lovastatin; Macrophage.; Pro inflammatory cytokine; Respiratory syncytial virus

Indexed keywords

CHOLESTEROL; F ACTIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MEVINOLIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA; STRUCTURAL PROTEIN; VIRUS PROTEIN; ANTIVIRUS AGENT; CYTOKINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL INCLUSION; CELL VIABILITY; COST EFFECTIVENESS ANALYSIS; CYTOKINE RELEASE; CYTOKINE RESPONSE; GENE EXPRESSION; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; MOLECULAR LIBRARY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS INFECTION; VIRUS PARTICLE; VIRUS TRANSMISSION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; MACROPHAGE; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECT; GENETICS; IMMUNOLOGY; PHYSIOLOGY; VIROLOGY;

MURINAE; RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CYTOKINES; FEMALE; HUMANS; LOVASTATIN; MACROPHAGES; MICE; MICE, INBRED BALB C; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES;

EID: 84876169450     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2013.03.015     Document Type: Article

References (28)

1. Becker, S., Quay, J., Soukup, J., 1991.Cytokine (tumornecrosis factor, IL-6, and IL-8) production by respiratory syncytial virus-infected human alveolar macrophages. J.Immunol.147, 4307-4312.
2. Becker, S., Soukup, J., Yankaskas, J.R., 1992.Respiratory syncytial virus infection of human primary nasal and bronchial epithelial cell cultures and bronchoalveolar macrophages. Am.J.Respir.Cell Mol.Biol.6, 369-374.
3. Brown, M.S., Dana, S.E., Goldstein, J.L., 1973.Regulation of3-Hydroxy-3- Methylglutaryl Coenzyme A Reductase Activity inHuman Fibroblasts by Lipoproteins. Proc.Natl.Acad.Sci.70, 2162-2166.
4. Cannon, M.J., 1987.Microplaque immunoperoxidase detection ofinfectious respiratory syncytial virus inthe lungs ofinfected mice.J.Virol.Methods 16, 293-301.
5. Chaudhry, M.Z., Wang, J.H., Blankson, S., Redmond, H.P., 2008.Statin (Cerivastatin) protects mice against sepsis-related death via reduced proinflammatory cytokines and enhanced bacterial clearance.Surg.Infect.9, 183-194.
6. Collins, P.L., Graham, B.S., 2008.Viral and host factors inhuman respiratory syncytial virus pathogenesis.J.Virol.82, 2040-2055.
7. Ferro, D., Parrotto, S., Basili, S., Alessandri, C., Violi, F., 2000.Simvastatin inhibits the monocyte expression ofproinflammatorycytokines inpatients with hypercholesterolemia. J.Am.Coll.Cardiol.36, 427-431.
8. Franke-Ullmann, G., Pfortner, C., Walter, P., Steinmuller, C., Lohmann-Matthes, M., Kobzik, L., Freihorst, J., 1995.Alteration ofpulmonary macrophage function by respiratory syncytial virus infection invitro.J.Immunol.154, 268-280.
9. Garcia, J., Garcia-Barreno, B., Vivo, A., Melero, J.A., 1993.Cytoplasmic inclusions of respiratory syncytial virus-infected cells: formation ofinclusion bodies in transfected cells that coexpress the nucleoprotein, the phosphoprotein, and the 22K protein. Virology 195, 243-247.
10. Gower, T.L., Graham, B.S., 2001.Antiviral activity oflovastatin against respiratory syncytial virus in vivo and invitro.Antimicrob.Agents Chemother.45, 1231-1237.
11. Haeberle, H.A., Takizawa, R., Casola, A., Brasier, A.R., Dieterich, H.J., Van Rooijen, N., Gatalica, Z., Garofalo, R.P., 2002.Respiratory syncytial virus-induced activation of nuclear factor-kappaB inthe lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. J.Infect.Dis.186, 1199-1206.
12. Huang, K.-C., Chen, C.-W., Chen, J.-C., Lin, W.-W., 2003.Statins induce suppressor of cytokine signaling-3 inmacrophages.FEBS Lett.555, 385-389.
13. Jeffree, C.E., Rixon, H.W., Brown, G., Aitken, J., Sugrue, R.J., 2003.Distribution ofthe attachment (G) glycoprotein and GM1 within the envelope ofmature respiratory syncytial virus filamentsrevealed using fieldemission scanning electron microscopy. Virology 306, 254-267.
14. Johnson, J.E., Gonzales, R.A., Olson, S.J., Wright, P.F., Graham, B.S., 2007.The histopathology offatal untreated human respiratory syncytial virus infection. Mod. Pathol.20, 108-119.
15. Keyomarsi, K., Sandoval, L., Band, V., Pardee, A.B., 1991.Synchronization oftumor and normal cells from G1tomultiple cell cycles bylovastatin.Cancer Res.51, 3602-3609.
16. Low, K.-W., Tan, T., Ng, K., Tan, B.-H., Sugrue, R.J., 2008.The RSV Fand G glycoproteins interact toform acomplex onthe surface ofinfected cells. Biochem. Biophys.Res.Commun.366, 308-313.
17. McDonald, T.P., Pitt, A.R., Brown, G., Rixon, H.W.M., Sugrue, R.J., 2004.Evidence that the respiratory syncytial virus polymerase complex associates with lipid rafts in virus-infected cells: aproteomic analysis.Virology 330, 147-157.
18. McNamara, P.S., Flanagan, B.F., Hart, C.A., Smyth, R.L., 2005.Production of Chemokines in the Lungs ofInfants with Severe Respiratory Syncytial Virus Bronchiolitis. J.Infect.Dis.191, 1225-1232.
19. Nair, H., Nokes, D.J., Gessner, B.D., Dherani, M., Madhi, S.A., Singleton, R.J., O'Brien, K.L., Roca, A., Wright, P.F., Bruce, N., Chandran, A., Theodoratou, E., Sutanto, A., Sedyaningsih, E.R., Ngama, M., Munywoki, P.K., Kartasasmita, C., Simões, E.A.F., Rudan, I., Weber, M.W., Campbell, H., 2010.Global burden ofacute lower respiratory infections due torespiratory syncytial virus inyoung children:a systematic review and meta-analysis. Lancet 375, 1545-1555.
20. Novack, V., Eisinger, M., Frenkel, A., Terblanche, M., Adhikari, N., Douvdevani, A., Amichay, D., Almog, Y., 2009.The effects ofstatin therapy oninflammatory cytokines in patients with bacterial infections:arandomized double-blind placebo controlled clinical trial. Intensive Care Med.35, 1255-1260.
21. Osborne, T.F., Gil, G., Brown, M.S., Kowal, R.C., Goldstein, J.L., 1987.Identificationof promoter elements required for in vitro transcription ofhamster 3-hydroxy-3- methylglutaryl coenzyme areductase gene.Proc.Natl.Acad.Sci.USA 84, 3614-3618.
22. Perrone, L.A., Plowden, J.K., Garcia-Sastre, A., Katz, J.M., Tumpey, T.M., 2008.H5N1 and 1918 pandemic influenzavirus infection results inearly and excessive infiltration ofmacrophages and neutrophils inthe lungs ofmice.PLoS Pathog.4, e1000115.
23. Pribul, P.K., Harker, J., Wang, B., Wang, H., Tregoning, J.S., Schwarze, J., Openshaw, P.J., 2008.Alveolar macrophages are amajor determinant ofearly responses to viral lung infection but donot influencesubsequent disease development.J. Virol. 82, 4441-4448.
24. Radhakrishnan, A., Yeo, D., Brown, G., Myaing, M.Z., Iyer, L.R., Fleck, R., Tan, B.H., Aitken, J., Sanmun, D., Tang, K., Yarwood, A., Brink, J., Sugrue, R.J., 2010.Protein analysis of purifiedrespiratory syncytial virus particles reveals animportant role for heat shock protein 90invirus particle assembly.Mol.Cell.Proteomics 9, 1829-1848.
25. Reed, J.L., Brewah, Y.A., Delaney, T., Welliver, T., Burwell, T., Benjamin, E., Kuta, E., Kozhich, A., McKinney, L., Suzich, J., Kiener, P.A., Avendano, L., Velozo, L., Humbles, A., Welliver, R.C., Coyle, A.J., 2008.Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis.J.Infect. Dis. 198, 1783-1793.
26. Rezaie-Majd, A., Maca, T., Bucek, R.A., Valent, P., Muller, M.R., Husslein, P., Kashanipour, A., Minar, E., Baghestanian, M., 2002.Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler.Thromb.Vasc.Biol.22, 1194-1199.
27. Sakamoto, N., Hayashi, S., Mukae, H., Vincent, R., Hogg, J.C., van Eeden, S.F., 2009. Effect of atorvastatin onPM10-induced cytokine production byhuman alveolar macrophages and bronchial epithelial cells. Int.J.Toxicol.28, 17-23.
28. Sugrue, R.J., Brown, C., Brown, G., Aitken, J., McL.Rixon, H.W., 2001.Furin cleavage of the respiratory syncytial virus fusion protein isnot arequirement for its transport to the surface ofvirus-infected cells.J.Gen.Virol.82, 1375-1386.