Neuroprotective role of withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism

Neurochemical Research

Volumn 38, Issue 5, 2013, Pages 972-980

  Prakash, Jay ^a   Yadav, Satyndra Kumar ^a   Chouhan, Shikha ^a   Singh, Surya Pratap ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Herbal extract; Maneb Paraquat; Motor activity; Oxidative stress; Tyrosine hydroxylase

Indexed keywords

CATALASE; MANEB; NITRITE; PARAQUAT; TYROSINE 3 MONOOXYGENASE; WITHANIA SOMNIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; GRIP STRENGTH; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MOTOR PERFORMANCE; MOUSE; NEUROPROTECTION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATIVE STRESS; PARKINSONISM; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

ANIMALS; DISEASE MODELS, ANIMAL; MANEB; MICE; NEUROPROTECTIVE AGENTS; PARAQUAT; PARKINSONIAN DISORDERS; PLANT EXTRACTS; PLANT ROOTS; WITHANIA;

MUS; PARKINSONIA; WITHANIA SOMNIFERA;

EID: 84876162684     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1005-4     Document Type: Article

References (56)

1. Dauer W, Przedborski S (2003) Parkinson's disease: mechanisms and models. Neuron 39:889-909 (Pubitemid 37130207)
2. Mounsey RB, Teismann P (2010) Mitochondrial dysfunction in Parkinson's disease pathogenesis and neuroprotection. Parkinsons Dis 2011:1-18
3. Fahn S (2000) The spectrum of levodopa-induced dyskinesias. Ann Neurol 4:2-11
4. Singh MP, Patel S, Dikshit M, Gupta YK (2006) Contribution of genomics and proteomics in understanding the role of modifying factors in Parkinson's disease. Indian J Biochem Biophys 43:69-81 (Pubitemid 44475398)
5. Singh C, Ahmad I, Kumar A (2007) Pesticides and metals induced Parkinson's disease: involvement of free radicals and oxidative stress. Cell Mol Biol 53:19-28 (Pubitemid 350164302)
6. Thiruchelvam M, Brockel BJ, Richfield EK, Baggs RB, Cory-Slechta DA (2000) Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease? Brain Res 873:225-234 (Pubitemid 30619046)
7. Cory-Slechta DA, Thiruchelvam M, Barlow BK, Richfield EK (2005) Developmental pesticide models of the Parkinson disease phenotype. Environ Health Perspect 113:1263-1270 (Pubitemid 41387671)
8. Patel S, Singh V, Kumar A, Gupta YK, Singh MP (2006) Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb-and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. Brain Res 1081:9-18
9. Uversky VN (2004) Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res 318:225-241 (Pubitemid 39362642)
10. Andreas S (2004) Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res 318:215-224 (Pubitemid 39366054)
11. Potashkin JA, Blume SR, Runkle NK (2011) Limitations of animal models of Parkinson's. Parkinsons Dis 2011:1-7
12. Yadav S, Dixit A, Agrawal S, Singh A, Srivastava G, Singh AK, Srivastava PK, Prakash O, Singh MP (2012) Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis. Mol Neurobiol 829:1-8
13. Somayajulu-Niţu M, Sandhu JK, Cohen J, Sikorska M, Sridhar TS, Matei A, Borowy-Borowski H, Pandey S (2009) Paraquat induces oxidative stress, neuronal loss in substantia nigra region and parkinsonism in adult rats: neuroprotection and amelioration of symptoms by water soluble formulation of coenzyme Q10. BMC Neurosci 10:1-12
14. Zhang J, Fitsanakis VA, Gu G, Jing D, Ao M, Amarnath V, Montine TJ (2003) Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction. J Neuro-chem 84:336-346 (Pubitemid 36182275)
15. Brooks AI, Chadwick CA, Gelbard HA, Cory-Slechta DA, Federoff HJ (1999) Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res 823:1-10 (Pubitemid 29225488)
16. Thiruchelvam M, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA (2000) The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implica-tions for Parkinson's disease. J Neurosci 20:9207-9214 (Pubitemid 32042923)
17. Gupta SP, Patel S, Yadav S, Singh AK, Singh S, Singh MP (2010) Involvement of nitric oxide in maneb and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation? Neurochem Res 35:1206-1213
18. Mishra LC, Singh BB, Dagenais S (2000) Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 5:334-346 (Pubitemid 30660827)
19. Sadrzadeh SMH, Saffari Y (2004) Iron and brain disorders. Am J Clin Pathol 121:64-70
20. Halliwell B, Gutteridge JMC (1985) Oxygen radicals and the nervous system. Trends Neurosci 8:22-29 (Pubitemid 15171404)
21. Kale M, Rathore N, John S, Bhatnagar D (1999) Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: a possible involvement of reactive oxygen species. Toxicol Lett 105:197-205 (Pubitemid 29164489)
22. Nagashayana N, Sankarankutty P, Nampoothiri MR, Mohan PK, Mohanakumar KP (2000) Association of L-DOPA with recovery following ayurveda medication in Parkinson's disease. J Neurol Sci 176:124-127 (Pubitemid 30621609)
23. Konar A, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK (2011) Protective role of Ashwagandha leaf extract and its component with an one on scopolamine-induced changes in the brain and brain-derived cells. PLoS One 6:1-11
24. Koppula S, Kumar H, More SV, Kim BW, Kim IS, Choi DK (2012) Recent advances on the neuroprotective potential of antioxidants in experimental models of Parkinson's disease. Int J Mol Sci 13:10608-10629
25. Bhattacharya A, Ghosal S, Bhattacharya SK (2001) Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J Ethnopharmacol 74:1-6 (Pubitemid 32008512)
26. Grandhi A, Mujumdar AM, Patwardhan B (1994) A comparative pharmacological investigation of Ashwagandha and Ginseng. J Ethnopharmacol 44:13-15
27. Kulkarni SK, Dhir A (2008) Withania somnifera: an Indian ginseng. Prog Neuro Pharmacol Biol Psychiatry 32:1093-1105
28. Kuboyama T, Tohda C, Zhao J, Nakamura N, Hattori M, Komatsu K (2002) Axon or dendrite predominant outgrowth induced by constituents from Ashwagandha. Neuro Rep 13:1715-1720 (Pubitemid 35333148)
29. Tohda C, Kuboyama T, Komatsu K (2005) Search for natural products related to regeneration of the neuronal network. Neurosignals 14:34-45 (Pubitemid 40868982)
30. Rajasankar S, Manivasagam T, Surendran S (2009) Ashwagandha leaf extract: a potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease. Neurosci Lett 454:11-15
31. Rajasankara S, Manivasagam T, Sankar V, Prakash S, Muthusamy R, Krishnamurti A, Surendran S (2009) Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse. J Ethnopharmacol 125:369-373
32. Surendran S, Shihabuddin LS, Clarke J, Taksir TV, Stewart GR, Parsons G, Yang W, Tyring SK, Michals-Matalon K, Matalon R (2004) Mouse neural progenitor cells differentiate into oligodendrocytes in the brain of a knockout mouse model of Canavan disease. Brain Res Dev Brain Res 153:19-27 (Pubitemid 39298873)
33. Mohanasundari M, Srinivasan MS, Sethupathy S, Sabesan M (2006) Enhanced neuroprotective effect by combination of bromocriptine and Hypericum perforatum extract against MPTP-induced neurotoxicity in mice. J Neurol Sci 249:140-144 (Pubitemid 44665916)
34. Pisa M (1998) Regional specialization of motor functions in the rat striatum: implications for the treatment of Parkinsonism. Prog Neuro Pharmacol Biol Psychiatry 12:217-224
35. Tillerson JL, Miller GW (2003) Grid performance test to measure behavioral impairment in the MPTP-treated-mouse model of parkinsonism. J Neurosci Methods 123:189-200 (Pubitemid 36279413)
36. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358 (Pubitemid 9194347)
37. Granger DL, Taintor RR, Boockvar KS, Hibbs JB (1996) Measurement of nitrate and nitrite in biological samples using nitrate reductase and Greiss reaction. Methods Enzymol 268:142-151 (Pubitemid 26286356)
38. Sinha AK (1972) Colorimetric assay of catalase. Anal Chem 47:389-394
39. Kumar A, Ahmad I, Shukla S, Singh BK, Patel DK, Pandey HP, Singh C (2010) Effect of zinc and paraquat co-exposure on neurodegeneration: modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats. Free Radic Res 44:950-965
40. Singh AK, Tiwari MN, Upadhyay G, Patel DK, Singh D, Prakash O, Singh MP (2012) Long-term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood. Neurobiol Aging 33:404-415
41. Mochizuki H, Hayakawa H, Migita M, Shibata M, Tanaka R, Suzuki A, Shimo-Nakanishi Y, Urabe T, Yamada M, Tamayose K, Shimada T, Miura M, Mizuno Y (2001) An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease. Proc Natl Acad Sci USA 98:10918-10923 (Pubitemid 32878719)
42. Kidd PM (2000) Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management. Altern Med Rev 6:502-529 (Pubitemid 32104062)
43. Rajasankar S, Manivasagam T, Albert Singh T, Krishnamurti A, Ramanathan M (2007) Prophylactic effect of Withania somonifera against MPTP induced Parkin-son's disease in mice. Cell Tissue Res 7:975-979
44. Schwarting RK, Bonatz AE, Carey RJ, Huston JP (1991) Relationships between indices of behavioral asymmetries and neurochemical changes following mesencephalic 6-hydroxydopamine injections. Brain Res 554:46-55
45. Fernagut PO, Diguet E, Labattu B, Tison F (2002) A simple method to measure stride length as an index of nigrostriatal dysfunction in mice. J Neurosci Methods 113:123-130 (Pubitemid 34076535)
46. Zafar KS, Sayeed I, Siddiqui A, Ahmad M, Salim S, Islam F (2003) Dose-dependent protective effect of selenium in partial lesion model of Parkinson's disease: neurobehavioral and neurochemical evidences. J Neurochem 84:438-446 (Pubitemid 36182242)
47. Ahmad M, Yousuf S, Khan MB, Saleem S, Ishrat T, Hoda Md N, Islam F (2006) Protective effects of ethanolic extract of delphinium denudatumin a rat model of Parkinson's disease. Human Expt Toxicol 25:361-368 (Pubitemid 44139562)
48. Dexter DT, Wells FR, Lees AJ, Agid F, Agid Y, Jenner P, Marsden CD (1989) Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J Neurochem 52:1830-1836 (Pubitemid 19140770)
49. Noack H, Possel H, Rethfeldt C, Keilhoff G, Wolf G (1999) Peroxynitrite med-iated damage and lowered superoxide tolerance in primary cor-tical glial cultures after induction of the inducible isoform of NOS. Glia 28:13-24 (Pubitemid 29475575)
50. Denicola A, Radi R (2005) Peroxynitrite and drug-dependent toxicity. Toxicology 208:273-288 (Pubitemid 40187337)
51. Antunes F, Nunes C, Laranjinha J, Cadenas E (2005) Redox interactions of nitric oxide with dopamine and its derivatives. Toxicology 208:207-212 (Pubitemid 40187332)
52. Jagetia GC, Malagi KJ, Baliga MS, Venkatesh P, Veruva RR (2004) Triphala, an ayurvedic rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging. J Altern Complement Med 10:971-978 (Pubitemid 40180003)
53. Bhatnagar M, Sharma D, Salvi M (2009) Neuroprotective effects of Withania somnifera dunal.: a possible mechanism. Neurochem Res 34:1975-1983
54. Ahmad I, Kumar A, Shukla S, Prasad Pandey H, Singh C (2008) The involvement of nitric oxide in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes. Free Radic Res 42:849-862
55. Yadav S, Gupta SP, Srivastava G, Srivastava PK, Singh MP (2011) Role of secondary mediators in caffeine-mediated neuroprotection in maneb and paraquat induced Parkinson's disease phenotype in the mouse. Neurochem Res 37:875-884
56. Cheng Y, He G, Mu X, Zhang T, Li X, Hu J, Xu B, Du G (2008) Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. Neurosci Lett 441:16-20