-
1
-
-
75649134941
-
Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes.
-
Roep BO, Peakman M. Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes. Nat Rev Immunol 2010; 10:145-152.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 145-152
-
-
Roep, B.O.1
Peakman, M.2
-
2
-
-
77955600908
-
Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies
-
Carey C, Purohit S, She JX. Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies. Expert Opin Med Diagn 2010; 4:397-410.
-
(2010)
Expert Opin Med Diagn
, vol.4
, pp. 397-410
-
-
Carey, C.1
Purohit, S.2
She, J.X.3
-
3
-
-
84855525638
-
The problems and promises of research into human immunology and autoimmune disease
-
Roep BO, Buckner J, Sawcer S, Toes R, Zipp F. The problems and promises of research into human immunology and autoimmune disease. Nat Med 2012; 18:48-53.
-
(2012)
Nat Med
, vol.18
, pp. 48-53
-
-
Roep, B.O.1
Buckner, J.2
Sawcer, S.3
Toes, R.4
Zipp, F.5
-
4
-
-
78751662679
-
Type 1 diabetes: etiology, immunology, and therapeutic strategies
-
van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 2011; 91:79-118.
-
(2011)
Physiol Rev
, vol.91
, pp. 79-118
-
-
van Belle, T.L.1
von Coppieters, K.T.2
Herrath, M.G.3
-
5
-
-
78650967712
-
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
-
Gaglia JL, Guimaraes AR, Harisinghani M etal. Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. J Clin Invest 2011; 121:442-445.
-
(2011)
J Clin Invest
, vol.121
, pp. 442-445
-
-
Gaglia, J.L.1
Guimaraes, A.R.2
Harisinghani, M.3
-
7
-
-
84857189975
-
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes
-
Bulek AM, Cole DK, Skowera A etal. Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes. Nat Immunol 2012; 13:283-289.
-
(2012)
Nat Immunol
, vol.13
, pp. 283-289
-
-
Bulek, A.M.1
Cole, D.K.2
Skowera, A.3
-
8
-
-
84857822895
-
MHC class II tetramers
-
Nepom GT. MHC class II tetramers. J Immunol 2012; 188:2477-2482.
-
(2012)
J Immunol
, vol.188
, pp. 2477-2482
-
-
Nepom, G.T.1
-
9
-
-
70350534475
-
Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes
-
Type 1 Diabetes TrialNet Research Group.
-
Herold KC, Brooks-Worrell B, Palmer J etal., Type 1 Diabetes TrialNet Research Group. Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes 2009; 58:2588-2595.
-
(2009)
Diabetes
, vol.58
, pp. 2588-2595
-
-
Herold, K.C.1
Brooks-Worrell, B.2
Palmer, J.3
-
10
-
-
80053628904
-
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
-
Crawford F, Stadinski B, Jin N etal. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci USA 2011; 108:16729-16734.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16729-16734
-
-
Crawford, F.1
Stadinski, B.2
Jin, N.3
-
11
-
-
77951983004
-
Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers
-
Velthuis JH, Unger WW, Abreu JR etal. Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes 2010; 59:1721-1730.
-
(2010)
Diabetes
, vol.59
, pp. 1721-1730
-
-
Velthuis, J.H.1
Unger, W.W.2
Abreu, J.R.3
-
12
-
-
84865631586
-
CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity
-
Abreu JR, Martina S, Verrijn Stuart AA etal. CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity. Clin Exp Immunol 2012; 170:57-65.
-
(2012)
Clin Exp Immunol
, vol.170
, pp. 57-65
-
-
Abreu, J.R.1
Martina, S.2
Verrijn Stuart, A.A.3
-
14
-
-
77449143100
-
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects
-
Long SA, Cerosaletti K, Bollyky PL etal. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes 2010; 59:407-415.
-
(2010)
Diabetes
, vol.59
, pp. 407-415
-
-
Long, S.A.1
Cerosaletti, K.2
Bollyky, P.L.3
-
15
-
-
34548735414
-
Both Langerhans cells and interstitial DC cross-present melanoma antigens and efficiently activate antigen-specific CTL
-
Cao T, Ueno H, Glaser C, Fay JW, Palucka AK, Banchereau J. Both Langerhans cells and interstitial DC cross-present melanoma antigens and efficiently activate antigen-specific CTL. Eur J Immunol 2007; 37:2657-2667.
-
(2007)
Eur J Immunol
, vol.37
, pp. 2657-2667
-
-
Cao, T.1
Ueno, H.2
Glaser, C.3
Fay, J.W.4
Palucka, A.K.5
Banchereau, J.6
-
16
-
-
84870911405
-
Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes
-
Levy H, Wang X, Kaldunski M etal. Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes. Genes Immun 2012; 13:593-604.
-
(2012)
Genes Immun
, vol.13
, pp. 593-604
-
-
Levy, H.1
Wang, X.2
Kaldunski, M.3
-
17
-
-
77952240517
-
A CD8+ T cell transcription signature predicts prognosis in autoimmune disease
-
1 p following 91.
-
McKinney EF, Lyons PA, Carr EJ etal. A CD8+ T cell transcription signature predicts prognosis in autoimmune disease. Nat Med 2010; 16:586-591, 1 p following 91.
-
(2010)
Nat Med
, vol.16
, pp. 586-591
-
-
McKinney, E.F.1
Lyons, P.A.2
Carr, E.J.3
-
18
-
-
34548786857
-
Gene expression in peripheral blood mononuclear cells from children with diabetes
-
Kaizer EC, Glaser CL, Chaussabel D, Banchereau J, Pascual V, White PC. Gene expression in peripheral blood mononuclear cells from children with diabetes. J Clin Endocrinol Metab 2007; 92:3705-3711.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 3705-3711
-
-
Kaizer, E.C.1
Glaser, C.L.2
Chaussabel, D.3
Banchereau, J.4
Pascual, V.5
White, P.C.6
-
19
-
-
80053070118
-
Nucleic acid programmable protein array a just-in-time multiplexed protein expression and purification platform
-
Qiu J, LaBaer J. Nucleic acid programmable protein array a just-in-time multiplexed protein expression and purification platform. Methods Enzymol 2011; 500:151-163.
-
(2011)
Methods Enzymol
, vol.500
, pp. 151-163
-
-
Qiu, J.1
LaBaer, J.2
-
20
-
-
82755197361
-
Detection of beta cell death in diabetes using differentially methylated circulating DNA
-
Akirav EM, Lebastchi J, Galvan EM etal. Detection of beta cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci USA 2011; 108:19018-19023.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 19018-19023
-
-
Akirav, E.M.1
Lebastchi, J.2
Galvan, E.M.3
-
21
-
-
67651099236
-
Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes
-
O'Neill SK, Liu E, Cambier JC. Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes 2009; 16:293-298.
-
(2009)
Curr Opin Endocrinol Diabetes Obes
, vol.16
, pp. 293-298
-
-
O'Neill, S.K.1
Liu, E.2
Cambier, J.C.3
-
22
-
-
51249106861
-
Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies
-
Bradshaw EM, Kent SC, Tripuraneni V etal. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol 2008; 129:10-18.
-
(2008)
Clin Immunol
, vol.129
, pp. 10-18
-
-
Bradshaw, E.M.1
Kent, S.C.2
Tripuraneni, V.3
-
23
-
-
70449704670
-
Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells
-
Bradshaw EM, Raddassi K, Elyaman W etal. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol 2009; 183:4432-4439.
-
(2009)
J Immunol
, vol.183
, pp. 4432-4439
-
-
Bradshaw, E.M.1
Raddassi, K.2
Elyaman, W.3
-
24
-
-
79960675810
-
Novel automated blood separations validate whole cell biomarkers
-
Burger DE, Wang L, Ban L etal. Novel automated blood separations validate whole cell biomarkers. PLoS One 2011; 6:e22430.
-
(2011)
PLoS One
, vol.6
-
-
Burger, D.E.1
Wang, L.2
Ban, L.3
-
25
-
-
84856278095
-
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes
-
Newell EW, Sigal N, Bendall SC, Nolan GP, Davis MM. Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity 2012; 36:142-152.
-
(2012)
Immunity
, vol.36
, pp. 142-152
-
-
Newell, E.W.1
Sigal, N.2
Bendall, S.C.3
Nolan, G.P.4
Davis, M.M.5
-
26
-
-
38649093306
-
Whole genome searching with shotgun proteomic data: applications for genome annotation
-
Sevinsky JR, Cargile BJ, Bunger MK etal. Whole genome searching with shotgun proteomic data: applications for genome annotation. J Proteome Res 2008; 7:80-88.
-
(2008)
J Proteome Res
, vol.7
, pp. 80-88
-
-
Sevinsky, J.R.1
Cargile, B.J.2
Bunger, M.K.3
-
27
-
-
77949869612
-
Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high resolution differential mass spectrometry
-
Paweletz CP, Wiener MC, Bondarenko AY etal. Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high resolution differential mass spectrometry. J Proteome Res 2010; 9:1392-1401.
-
(2010)
J Proteome Res
, vol.9
, pp. 1392-1401
-
-
Paweletz, C.P.1
Wiener, M.C.2
Bondarenko, A.Y.3
-
28
-
-
79953737332
-
Metabolite profiles and the risk of developing diabetes
-
Wang TJ, Larson MG, Vasan RS etal. Metabolite profiles and the risk of developing diabetes. Nat Med 2011; 17:448-453.
-
(2011)
Nat Med
, vol.17
, pp. 448-453
-
-
Wang, T.J.1
Larson, M.G.2
Vasan, R.S.3
-
29
-
-
80555146689
-
Discovery and validation of serum protein changes in type 1 diabetes patients using high throughput two dimensional liquid chromatography-mass spectrometry and immunoassays
-
Zhi W, Sharma A, Purohit S etal. Discovery and validation of serum protein changes in type 1 diabetes patients using high throughput two dimensional liquid chromatography-mass spectrometry and immunoassays. Mol Cell Proteomics 2011; 10:M111012203.
-
(2011)
Mol Cell Proteomics
, vol.10
-
-
Zhi, W.1
Sharma, A.2
Purohit, S.3
-
30
-
-
80855133308
-
Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screening
-
Tiberti C, Yu L, Lucantoni F etal. Detection of four diabetes specific autoantibodies in a single radioimmunoassay: an innovative high-throughput approach for autoimmune diabetes screening. Clin Exp Immunol 2011; 166:317-324.
-
(2011)
Clin Exp Immunol
, vol.166
, pp. 317-324
-
-
Tiberti, C.1
Yu, L.2
Lucantoni, F.3
-
31
-
-
84857728420
-
Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes
-
Hober D, Sane F, Jaidane H, Riedweg K, Goffard A, Desailloud R. Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes. Clin Exp Immunol 2012; 168:47-51.
-
(2012)
Clin Exp Immunol
, vol.168
, pp. 47-51
-
-
Hober, D.1
Sane, F.2
Jaidane, H.3
Riedweg, K.4
Goffard, A.5
Desailloud, R.6
-
32
-
-
84857715156
-
Immunology in the clinic review series; focus on type 1 diabetes and viruses: enterovirus, thymus and type 1 diabetes pathogenesis
-
Jaidane H, Sane F, Hiar R etal. Immunology in the clinic review series; focus on type 1 diabetes and viruses: enterovirus, thymus and type 1 diabetes pathogenesis. Clin Exp Immunol 2012; 168:39-46.
-
(2012)
Clin Exp Immunol
, vol.168
, pp. 39-46
-
-
Jaidane, H.1
Sane, F.2
Hiar, R.3
-
33
-
-
84857737745
-
Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes
-
Lind K, Huhn MH, Flodstrom-Tullberg M. Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes. Clin Exp Immunol 2012; 168:30-38.
-
(2012)
Clin Exp Immunol
, vol.168
, pp. 30-38
-
-
Lind, K.1
Huhn, M.H.2
Flodstrom-Tullberg, M.3
-
34
-
-
84857700539
-
Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function
-
Grieco FA, Sebastiani G, Spagnuolo I, Patti A, Dotta F. Immunology in the clinic review series; focus on type 1 diabetes and viruses: how viral infections modulate beta cell function. Clin Exp Immunol 2012; 168:24-29.
-
(2012)
Clin Exp Immunol
, vol.168
, pp. 24-29
-
-
Grieco, F.A.1
Sebastiani, G.2
Spagnuolo, I.3
Patti, A.4
Dotta, F.5
-
35
-
-
84857753583
-
Immunology in the clinic review series; focus on type 1 diabetes and viruses: the enterovirus link to type 1 diabetes: critical review of human studies
-
Stene LC, Rewers M. Immunology in the clinic review series; focus on type 1 diabetes and viruses: the enterovirus link to type 1 diabetes: critical review of human studies. Clin Exp Immunol 2012; 168:12-23.
-
(2012)
Clin Exp Immunol
, vol.168
, pp. 12-23
-
-
Stene, L.C.1
Rewers, M.2
-
36
-
-
84857751555
-
Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma
-
Coppieters KT, Wiberg A, Tracy SM, von Herrath MG. Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma. Clin Exp Immunol 2012; 168:5-11.
-
(2012)
Clin Exp Immunol
, vol.168
, pp. 5-11
-
-
Coppieters, K.T.1
Wiberg, A.2
von Tracy, S.M.3
Herrath, M.G.4
-
37
-
-
84857724395
-
Viruses and type 1 diabetes: ignorance acquires a better vocabulary
-
Gale EA. Viruses and type 1 diabetes: ignorance acquires a better vocabulary. Clin Exp Immunol 2012; 168:1-4.
-
(2012)
Clin Exp Immunol
, vol.168
, pp. 1-4
-
-
Gale, E.A.1
-
38
-
-
84867221309
-
Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes
-
Han D, Cai X, Wen J etal. Innate and adaptive immune gene expression profiles as biomarkers in human type 1 diabetes. Clin Exp Immunol 2012; 170:131-138.
-
(2012)
Clin Exp Immunol
, vol.170
, pp. 131-138
-
-
Han, D.1
Cai, X.2
Wen, J.3
-
39
-
-
78649740257
-
Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society
-
Mallone R, Mannering SI, Brooks-Worrell BM etal. Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society. Clin Exp Immunol 2011; 163:33-49.
-
(2011)
Clin Exp Immunol
, vol.163
, pp. 33-49
-
-
Mallone, R.1
Mannering, S.I.2
Brooks-Worrell, B.M.3
-
40
-
-
84867041203
-
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes
-
Campbell-Thompson M, Wasserfall C, Kaddis J etal. Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes. Diabetes Metab Res Rev 2012; 28:608-617.
-
(2012)
Diabetes Metab Res Rev
, vol.28
, pp. 608-617
-
-
Campbell-Thompson, M.1
Wasserfall, C.2
Kaddis, J.3
|