Impurities preparation of sodium tanshinone IIA sulfonate by high-speed counter-current chromatography and identification by liquid chromatography/multistage tandem mass spectrometry

Journal of Chromatography A

Volumn 1288, Issue , 2013, Pages 28-34

  Chen, Shanqiao ^a,b,c   Zhao, Xin ^a,b   Li, You ^a,b,c   Yang, Dan ^a,b,c   Zhou, Tingting ^a,b   Fan, Guorong ^a,b  

^a SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c SHANGHAI OCEAN UNIVERSITY   (China)

Author keywords

Counter current chromatography; Impurity; LC MSn; Reference compounds; Sodium Tanshinone IIA Sulfonate

Indexed keywords

CLINICAL TREATMENTS; COUNTERCURRENT CHROMATOGRAPHY; HIGH-SPEED COUNTER-CURRENT CHROMATOGRAPHY; LC-MS N; REFERENCE COMPOUNDS; RELATED SUBSTANCES; TANDEM MASS SPECTROMETRY; TANSHINONE II A;

CHEMICAL MODIFICATION; EMULSIFICATION; IMPURITIES; LIQUIDS; LOADING; MASS SPECTROMETRY; ORGANIC SOLVENTS; SODIUM;

LIQUID CHROMATOGRAPHY;

AMMONIUM ACETATE; BUTANOL; CARDIOVASCULAR AGENT; CHLOROFORM; METHANOL; TANSHINONE IIA SULFONIC ACID; UNCLASSIFIED DRUG; WATER;

AQUEOUS SOLUTION; ARTICLE; COUNTER CURRENT CHROMATOGRAPHY; DRUG IMPURITY; DRUG PURITY; DRUG STRUCTURE; EMULSION; HIGH SPEED COUNTER CURRENT CHROMATOGRAPHY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PRODUCT RECOVERY; PROTON NUCLEAR MAGNETIC RESONANCE; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUNTERCURRENT DISTRIBUTION; DRUG CONTAMINATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHENANTHRENES; TANDEM MASS SPECTROMETRY;

EID: 84876083043     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.02.055     Document Type: Article

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