In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 15, 2013, Pages 5846-5851

  Tao, Pan ^a   Mahalingam, Marthandan ^a   Marasa, Bernard S ^a   Zhang, Zhihong ^a   Chopra, Ashok K ^b   Rao, Venigalla B ^a  

^a CATHOLIC UNIVERSITY OF AMERICA   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Gene therapy; Phage assembly; Protein and dna delivery; Protein display

Indexed keywords

BACTERIOPHAGE DNA; CAPSID PROTEIN; DENDRITIC CELL VACCINE; F1 V PROTEIN; NANOPARTICLE; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BACTERIOPHAGE T4; CELLULAR IMMUNITY; DENDRITIC CELL; DNA PACKAGING; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IN VITRO GENE TRANSFER; IN VIVO GENE TRANSFER; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; RECEPTOR GENE; REPORTER GENE; VIRUS CAPSID; VIRUS GENOME; YERSINIA PESTIS;

ANIMALS; ANTIGEN-PRESENTING CELLS; BACTERIOPHAGE T4; BINDING SITES; CAPSID PROTEINS; DENDRITIC CELLS; DNA PACKAGING; DNA, VIRAL; ESCHERICHIA COLI; GENE TRANSFER TECHNIQUES; HEK293 CELLS; HUMANS; MICE; NANOPARTICLES; PLASMIDS; YERSINIA PESTIS;

MAMMALIA; MIRIDAE; MUS;

EID: 84876065936     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300867110     Document Type: Article

References (31)

1. Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH (1982) Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J 1(7):841-845.
2. Kay MA (2011) State-of-the-art gene-based therapies: The road ahead. Nat Rev Genet 12(5):316-328.
3. Demayo JL, Wang J, Liang D, Zhang R, Demayo FJ (2012) Genetically Engineered Mice by Pronuclear DNA microinjection. Curr Protoc Mouse Biol 2:245-262.
4. Yan M, et al. (2010) A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol 5(1):48-53.
5. Kaczmarczyk SJ, Sitaraman K, Young HA, Hughes SH, Chatterjee DK (2011) Protein delivery using engineered virus-like particles. Proc Natl Acad Sci USA 108(41):16998-17003.
6. Smith DE, et al. (2001) The bacteriophage straight phi29 portal motor can package DNA against a large internal force. Nature 413(6857):748-752.
7. Fuller DN, Raymer DM, Kottadiel VI, Rao VB, Smith DE (2007) Single phage T4 DNA packaging motors exhibit large force generation, high velocity, and dynamic variability. Proc Natl Acad Sci USA 104(43):16868-16873.
8. Rao VB, Feiss M (2008) The bacteriophage DNA packaging motor. Annu Rev Genet 42:647-681.
9. Sun S, et al. (2008) The structure of the phage T4 DNA packaging motor suggests a mechanism dependent on electrostatic forces. Cell 135(7):1251-1262.
10. Fokine A, et al. (2004) Molecular architecture of the prolate head of bacteriophage T4. Proc Natl Acad Sci USA 101(16):6003-6008.
11. Qin L, Fokine A, O' Donnell E, Rao VB, Rossmann MG (2010) Structure of the small outer capsid protein, Soc: A clamp for stabilizing capsids of T4-like phages. J Mol Biol 395(4):728-741.
12. Fokine A, et al. (2011) Structure of the three N-terminal immunoglobulin domains of the highly immunogenic outer capsid protein from a T4-like bacteriophage. J Virol 85(16):8141-8148.
13. Ishii T, Yanagida M (1977) The two dispensable structural proteins (soc and hoc) of the T4 phage capsid; their purification and properties, isolation and characterization of the defective mutants, and their binding with the defective heads in vitro. J Mol Biol 109(4):487-514.
14. Li Q, Shivachandra SB, Zhang Z, Rao VB (2007) Assembly of the small outer capsid protein, Soc, on bacteriophage T4: a novel system for high density display of multiple large anthrax toxins and foreign proteins on phage capsid. J Mol Biol 370(5):1006-1019.
15. Zhang Z, et al. (2011) A promiscuous DNA packaging machine from bacteriophage T4. PLoS Biol 9(2):e1000592.
16. Lander GC, et al. (2006) The structure of an infectious P22 virion shows the signal for headful DNA packaging. Science 312(5781):1791-1795.
17. Leffers G, Rao VB (1996) A discontinuous headful packaging model for packaging less than headful length DNA molecules by bacteriophage T4. J Mol Biol 258(5):839-850.
18. Sathaliyawala T, et al. (2006) Assembly of human immunodeficiency virus (HIV) antigens on bacteriophage T4: A novel in vitro approach to construct multicomponent HIV vaccines. J Virol 80(15):7688-7698.
19. Milletti F (2012) Cell-penetrating peptides: classes, origin, and current landscape. Drug Discov Today 17(15-16):850-860.
20. Grimm D, et al. (2008) In vitro and in vivo gene therapy vector evolution via multi-species interbreeding and retargeting of adeno-associated viruses. J Virol 82(12):5887-5911.
21. Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449(7161):419-426.
22. Bonifaz LC, et al. (2004) In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J Exp Med 199(6):815-824.
23. van Kooten C, Banchereau J (2000) CD40-CD40 ligand. J Leukoc Biol 67(1):2-17.
24. Akerström B, Brodin T, Reis K, Björck L (1985) Protein G: A powerful tool for binding and detection of monoclonal and polyclonal antibodies. J Immunol 135(4):2589-2592.
25. Shen Z, Reznikoff G, Dranoff G, Rock KL (1997) Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. J Immunol 158(6):2723-2730.
26. Yang L, et al. (2008) Engineered lentivector targeting of dendritic cells for in vivo immunization. Nat Biotechnol 26(3):326-334.
27. Rappuoli R (2007) Bridging the knowledge gaps in vaccine design. Nat Biotechnol 25(12):1361-1366.
28. Davtyan H, et al. (2010) DNA prime-protein boost increased the titer, avidity and persistence of anti-Abeta antibodies in wild-type mice. Gene Ther 17(2):261-271.
29. Smiley ST (2008) Current challenges in the development of vaccines for pneumonic plague. Expert Rev Vaccines 7(2):209-221.
30. Leuschner F, et al. (2011) Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 29(11):1005-1010.
31. Miki K, et al. (2012) Bioengineered myocardium derived from induced pluripotent stem cells improves cardiac function and attenuates cardiac remodeling following chronic myocardial infarction in rats. Stem Cells Transl Med 1(5):430-437.