Possible revival of atrophied islet cells of the pancreas by vernonia amygdalina in alloxan induced diabetic rats

Journal of Applied Pharmaceutical Science

Volumn 2, Issue 9, 2012, Pages 127-131

  Sunday, Josiah J ^a   Spencer, Nwangwu C O ^a   Kingsley, Omage ^a   Akintola, Abdulrahamon A ^a   Binyelum, Nkwonta ^a   Favour, Aderoju O ^a  

^a IGBINEDION UNIVERSITY   (Nigeria)

Author keywords

Alloxan monohydrate; Glucometer.; Glucose; Histopathology; Islet cells; Vernonia amygdalina

Indexed keywords

EID: 84876048014     PISSN: None     EISSN: 22313354     Source Type: Journal    
DOI: 10.7324/JAPS.2012.2925     Document Type: Article

References (12)

1. Abosi A.O., Raseoka B.H. In vivo antimalarial activity of Vernonia amygdalina. British Journal of Biomedical Science. 2003; 60(2): 89-91.
2. Akah P.A., Okafor C.L. Blood sugar lowering effect of Vernonia amygdalina in an experimental rabbit model. Phytotherapy Research. 1992; 6: 171-173.
3. Famuyiwa O. O., Adenaike F. A., Osotimehin B. O., Adetuyibi A. A. Clinical study of diabetic neuropathy in Nigerian diabetic patients. Nigerian Medical Journal. 1998; 18(1): 265-268.
4. Hamowia A.M., Saffaf A.M. Pharmacological studies on Vernonia amygdalina (Del) and Tithoria diversifolia (Gray). Vet. Med. J. Giza. 1994; 2: 91-97.
5. Izevbigie E.B. Discovery of water soluble anticancer agents (edodites from a vegetable found in Benin City, Nigeria).Experimental Biology and Medicine. 2003; 228(3): 293-298.
6. Kambizi L., Afolayan A. J. An ethnobotanical study of plants used for treatment of sexually transmitted diseases (njovhera) in Guruve District, Zimbabwe. Journal of Ethnopharmacology. 2001; 77(1): 5-9.
7. Kupcham S. M., Hemingway R. J., Karim A. A., Wemer D. Tumor inhibitors. XLVII. Vernodalin and Vernomygdin, two new cytotoxic sesquiterpene lactones from Vernonia amygdalina. Journal of Organic Chemistry. 1969; 34(12): 3908
8. Omamoto H., Ucgigate Y., Hiroskitckan. STZ and alloxan induces DNA strand breaks and poly (ADP ribose) synthetase in pancreatic islet. Nature. 1981; 294: 284-286.
9. Philipson J. D., Wright C.W., Kirby G. C., Warhust D. C. Phytochemistry of some plants used in traditional medicine for the treatment of protozoal diseases. Pyhtotherapy Research. 1993; 9: 504-508.
10. Uhegbu F.O., Ogbuehi K. J. Effect of the aqueous extract (crude) of leaves of Vernonia amygdalina on blood glucose, serum cholesterol & serum albumin levels in alloxan induced diabetic albino rats. Global journal of Pure and Applied Science. 2004; 10: 189-194.
11. Yeap S.K., HO W.Y., Beh B. K., Lieng W. S., KyH A. Noorjahan B. A. Vernonia amygdalina, an ethnoverterinary and ethnomedical use of green vegetables with multiple bioactivities. Journal of medicinal plants research. 2010; 4(25): 2787-2812.
12. Youdim K., McDonald J., Kalt W., Joseph J. Potential role of dietary flavonoids in reducing micro-vascular endothelium volubility to oxidative and inflammatory results. Journal of Nutritional Biochemistry. 2007; 13(5): 282-288.