Synthesis and anticholinesterase activities of novel 1,3,4-thiadiazole based compounds

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 28, Issue 4, 2013, Pages 816-823

  Skrzypek, Alicja ^a   Matysiak, Joanna ^a   Karpińska, Monika M ^b   Niewiadomy, Andrzej ^a,b  

^a UNIVERSITY OF LIFE SCIENCES IN LUBLIN   (Poland)

^b INSTITUTE OF INDUSTRIAL ORGANIC CHEMISTRY   (Poland)

Author keywords

1,3,4 Thiadiazole; Acetylcholinesterase; Butyrylcholinesterase; Inhibitor; Synthesis

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; 3 [5 [4 (DIMETHYLAMINO)PHENYL] 1,3,4 THIADIAZOL 2 YL]BIPHENYL 2,3',4,5',6 PENTO; 4 (2,4 DICHLOROPHENOXYMETHYL)BENZENE 1,3 DIOL; 4 (5 BENZYL 1,3,4 THIADIAZOL 2 YL) 6 CHLOROBENZENE 1,3 DIOL; 4 (5 HEPTYL 1,3,4 THIADIAZOL 2 YL)BENZENE 1,3 DIOL; 4 (5 PROPYL 1,3,4 THIADIAZOL 2 YL)BENZENE 1,3 DIOL; 4 [5 (1,3 BENZODIOXOL 5 YL) 1,3,4 THIADIAZOL 2 YL]BENZENE 1,3 DIOL; 4 [5 (NAPHTHALEN 2 YL) 1,3,4 THIADIAZOL 2 YL]BENZENE 1,3 DIOL; 4 [5 [4 (TRIFLUOROMETHYL)PHENYLAMINO] 1,3,4 THIADIAZOL 2 YL]BENZENE 1,3 DIOL; 4 [5 [5 (4 BROMOPHENYL) 1,2 OXAZOL 3 YL] 1,3,4 THIADIAZOL 2 YL]BENZENE 1,3 DIOL; 4 [5 [5 (4 BROMOPHENYL)THIOPHEN 2 YL] 1,3,4 THIADIAZOL 2 YL]BENZENE 1,3 DIOL; 4 [5 [5 (4 FLUOROPHENYL)THIOPHEN 2 YL] 1,3,4 THIADIAZOL 2 YL]BENZENE 1,3 DIOL; 4 CHLORO 6 [5 (3 CHLOROPHENYLAMINO) 1,3,4 THIADIAZOL 2 YL]BENZENE 1,3 DIOL; 4 CHLORO 6 [5 (3,4 DIHYDROXYPHENYL) 1,3,4 THIADIAZOL 2 YL]BENZENE 1,3 DIOL; 4 CHLORO 6 [5 (4 FLUOROPHENYLAMINO) 1,3,4 THIADIAZOL 2 YL]BENZENE 1,3 DIOL; 4,4' [[5,5' (BENZENE 1,4 DIYL)] BIS(1,3,4 THIADIAZOL 2 YL)]DI(BENZENE 1,3 DIOL); ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHOLINESTERASE INHIBITION; COMPETITIVE INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 84876042250     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2012.688041     Document Type: Article

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