Difficult times for Alzheimer's treatments

Drug Discovery Today

Volumn 10, Issue 20, 2005, Pages 1333-1335

  O'Neill, Michael F ^a  

^a Eolas Biosciences ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ALZHEIMER DISEASE VACCINE; AMPA RECEPTOR AGONIST; AMYLOID; ANTIINFLAMMATORY AGENT; ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; CHOLINESTERASE INHIBITOR; CLIOQUINOL; CLOZAPINE; DONEPEZIL; FLUOXETINE PLUS OLANZAPINE; GALANTAMINE; HISTAMINE H3 RECEPTOR ANTAGONIST; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEMANTINE; METAL CHELATE; NEUROLEPTIC AGENT; NICOTINIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OLANZAPINE; QUETIAPINE; RISPERIDOL; RISPERIDONE; RIVASTIGMINE; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; ZIPRASIDONE;

ALZHEIMER DISEASE; BEHAVIOR DISORDER; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; DRUG ACTIVITY; DRUG EFFECT; DRUG FATALITY; DRUG SAFETY; EDITORIAL; HUMAN; IMMUNIZATION; MENINGOENCEPHALITIS; NEUROPROTECTION; PNEUMONIA; PROPHYLAXIS; PSYCHOSIS; VACCINATION;

ALZHEIMER DISEASE; ALZHEIMER VACCINES; AMYLOID BETA-PROTEIN; ANTIPSYCHOTIC AGENTS; CHOLINESTERASE INHIBITORS; HUMANS; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME; VITAMIN E; VITAMINS;

EID: 27144492977     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(05)03604-4     Document Type: Editorial

References (10)

1. Bullock R. Treatment of behavioural and psychiatric symptoms in dementia: implications of recent safety warnings Curr. Med. Res. Opin. 21 2005 1 10
2. Gelinas D.S. Immunotherapy for Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 101 Suppl. 2 2004 14657 14662
3. Behl C., Moosman B. Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants and neuroprotection Biol. Chem. 383 2002 521 536
4. Petersen R.C. Vitamine E and donepezil for the treatment of mild cognitive impairment N. Engl. J. Med. 352 2005 2439 2441
5. Miller E.R. III Meta-analysis: high dosage vitamin E supplementation may increase all-cause mortality Ann. Intern. Med. 142 2005 37 46
6. Zandi P.P. Cache County Study investigators. Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study. Arch. Gen. Psychiatry 62 2005 217 224
7. De Craen A.J.M. Meta-analysis of nonsteroidal anti-inflammatory drug use and risk of dementia Am. J. Epidemiol. 161 2005 114 120
8. National Institute for Clinical Excellence (2005) Appraisal Consultation Document. Donepezil, rivastigmine, galantamine and memantine for the treatment of Alzheimer's. Also see National Institute for Clinical Excellence. Update on Alzheimer's appraisal. Both available at http://medicines.mhra.gov.uk/
9. Mathews P.M., Nixon R.A. Setback for an Alzheimer's disease vaccine Neurology 61 2003 7 8
10. Johnson C.N. New symptomatic strategies in Alzheimer's disease Drug Disc. Today: Ther. Strat. 1 2005 13 19