Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research

Frontiers in Genetics

Volumn 3, Issue MAY, 2012, Pages

  Hirsch, Helmut V B ^a   Lnenicka, Gregory ^a   Possidente, Debra ^b   Possidente, Bernard ^b   Garfinkel, Mark D ^c   Wang, Luan ^d   Lu, Xiangyi ^d   Ruden, Douglas M ^d,e  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b SKIDMORE COLLEGE   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

^e WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Behavioral toxicology; Drosophila; Toxicogenomics; Toxicology

Indexed keywords

ANIMALIA; DROSOPHILA MELANOGASTER;

EID: 84876028852     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2012.00068     Document Type: Article

References (57)

1. Abu-Taweel, G. M., Ajarem, J. S., and Ahmad, M. (2012). Neurobehavioral toxic effects of perinatal oral exposure to aluminum on the developmental motor reflexes, learning, memory and brain neurotransmitters of mice offspring. Pharmacol Biochem. Behav. 101,49-5
2. Altmann, L., Weinsberg, F., Sveinsson, K., Lilienthal, H., Wiegand, H., andWinneke, G. (1993). Impairment of long-term potentiation and learning following chronic lead exposure. Toxicol. Lett. 66,105-11
3. Audesirk, G., and Audesirk, T. (1989). Effects of in vitro lead exposure on voltage-sensitive calcium channels differ among cell types in central neurons of Lym-naea stagnalis. Neurotoxicology 10, 659-66
4. Broman, K.W. (2005). Mapping expression in randomized rodent genomes. Nat. Genet. 37, 209-210. [see comments].
5. Broman, K. W., Wu, H., Sen, S., and Churchill, G. A. (2003). R/qtl: QTL mapping in experimental crosses. Bioinformatics 19, 889-89
6. Budnik, V. (1996). Synapse maturation and structural plasticity at Drosophila neuromuscular junctions. Curr. Opin. Neurobiol. 6, 858-86
7. Budnik, V., Koh, Y. H., Guan, B., Hartmann, B., Hough, C., Woods, D., and Gorczyca, M. (1996). Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg. Neuron 17, 627-64
8. Campagna, D., Huel, G., Hellier, G., Girard, F., Sahuquillo, J., Fagot-Campagna, A., Godin, J., and Blot, P. (2000). Negative relationships between erythrocyte Capump activity and lead levels in mothers and newborns. Life Sci. 68, 203-21
9. Counter, S. A., Buchanan, L. H., Rosas, H. D., and Ortega, E (1998). Neurocognitive effects of chronic lead intoxication in Andean children. J.Neurol Sci. 160,47-5
10. Davis, G. W., Schuster, C. M., and Goodman, C. S. (1996). Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron 17, 669-67
11. de Koning, D. J., and Haley, C. S. (2005). Genetical genomics in humans and model organisms. Trends Genet. 21, 377-38
12. Empson, R. M., Garside, M. L., and Knopfel, T. (2007). Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse. J. Neurosci. 27, 3753-375
13. 2+ blocks calcium currents of cultured dorsal root ganglion cells. Neurosci. Lett. 129,103-10
14. Faroon, O., Jones, D., and de Rosa, C. (2000). Effects of polychlorinated biphenyls on the nervous system. Toxicol. Ind. Health 16, 305-33
15. He, T., Hirsch, H. V. B., Ruden, D. M., and Lnenicka, G. A. (2009). Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae. Neurotoxicology 30, 777-78
16. Hirsch, H. V., Mercer, J., Sambaziotis, H., Huber, M., Stark, D. T., Torno-Morley, T., Hollocher, K., Ghiradella, H., and Ruden, D. M. (2003). Behavioral effects of chronic exposure to low levels of lead in Drosophila melanogaster. Neurotoxicology 24,435-44
17. Hirsch, H. V. B., Possidente, D., Averill, S., Despain, T. P., Buytkins, J., Thomas, V., Goebel, W. P., Shipp-Hilts, A., Wilson, D., Hollocher, K., Possidente, B., Lnenicka, G., and Ruden, D. M. (2009). Variations at a quantitative trait locus (QTL) affect development of behavior in lead-exposed Drosophila melanogaster. Neurotoxicology 30, 305-31
18. Hovatta, I., Zapala, M. A., Broide, R. S., Schadt, E. E., Libiger, O., Schork, N. J., Lockhart, D. J., and Barlow, C. (2007). DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biol. 8,R2
19. Jansen, R. C., and Nap, J. P. (2001). Genetical genomics: the added value from segregation. Trends Genet. 17, 388-39
20. 2+-dependent regulation of rho GTPases triggers turning of nerve growth cones. J. Neurosci. 25, 2338-234
21. Keshishian, H., Broadie, K., Chiba, A., and Bate, M. (1996). The Drosophila neuromuscular junction: a model system for studying synaptic development and function. Annu. Rev. Neurosci. 19, 545-57
22. Kiraly, E., and Jones, D. G. (1982). Dendritic spine changes in rat hippocampal pyramidal cells after postnatal lead treatment: a Golgi study. Exp. Neurol. 77, 236-23
23. Levi, F., Okyar, A., Dulong, S., Innominato, P. F., and Clairambault, J. (2010). Circadian timing in cancer treatments. Annu. Rev. Pharmacol. Toxicol. 50,377-42
24. Li, J., and Burmeister, M. (2005). Genetical genomics: combining genetics with gene expression analysis. Hum. Mol. Genet. 14, R163-R16
25. Li, X. M., Delaunay, F., Dulong, S., Claustrat, B., Zampera, S., Fujii, Y., Teboul, M., Beau, J., and Levi, E (2010). Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing. Cancer Res. 70, 3351-336
26. Li, Y., Álvarez, O. A., Gutteling, E. W., Tijsterman, M., Fu, J., Riksen, J. A. G., Hazendonk, E., Prins, P., Plasterk, R. H. A., Jansen, R. C., Breitling, R., and Kammenga, J. E. (2006). Mapping determinants of gene expression plasticity by genetical genomics in C. elegans. PLoS Genet. 2, e222. doi: 10.1371/journal.pgen.0020222
27. Li, Y., Breitling, R., and Jansen, R. C. (2008). Generalizing genetical genomics: getting added value from environmental perturbation. Trends Genet. 24, 518-52
28. Lohmann, C., and Bonhoeffer, T. (2008). A role for local calcium signaling in rapid synaptic partner selection by dendritic filopodia. Neuron 59,253-26
29. MacDonald, J. F., Jackson, M. F., and Beazely, M. A. (2006). Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors. Crit. Rev. Neurobiol. 18, 71-8
30. Mackay, T. E C., and Anholt, R. R. H. (2006). Of flies and man: Drosophila as a model for human complex traits. Annu. Rev. Genomics Hum. Genet. 7, 339-36
31. Majewski, J., and Pastinen, T. (2011). The study of eQTL variations by RNA-seq: from SNPs to phenotypes. Trends Genet. 27, 72-7
32. 2+)-ATPase activity. Calmodulin involvement. Mol. Cell. Biochem. 89, 87-9
33. Mayersbach, H. (1976). Time-akey in experimental and practical medicine. Arch. Toxicol. 36, 185-21
34. Morley, E. J., Hirsch, H. V., Hollocher, K., and Lnenicka, G. A. (2003). Effects of chronic lead exposure on the neuromuscular junction in Drosophila larvae. Neurotoxicology 24,35-4
35. Mueller, M., Goel, A., Thimma, M., Dickens, N. J., Aitman, T. J., and Mangion, J. (2006). eQTL Explorer: integrated mining of combined genetic linkage and expression experiments. Bioinformatics 22, 509-51
36. Petit, T. L., and LeBoutillier, J. C. (1979). Effects of lead exposure during development on neocortical dendritic and synaptic structure. Exp. Neurol. 64, 482-49
37. Prakash, S. (2011). Human metabolic individuality in biomedical and pharmaceutical research. Circ. Cardiovasc. Genet. 4, 714-71
38. Pratt, K. G., Watt, A. J., Griffith, L. C., Nelson, S. B., and Turrigiano, G. G. (2003). Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII. Neuron 39,269-28
39. Rai, A., Maurya, S. K., Khare, P., Srivastava, A., and Bandyopadhyay, S. (2010). Characterization of developmental neurotoxicity of As, Cd, and Pb mixture: synergistic action of metal mixture in glial and neuronal functions. Toxicol. Sci. 118, 586-60
40. Rockman, M. V., and Kruglyak, L. (2006). Genetics of global gene expression. Nat. Rev. Genet. 7, 862-87
41. Rosato, E., and Kyriacou, C. P. (2006). Analysis of locomotor activity rhythms in Drosophila. Nat. Protoc. 1,559-56
42. Rosato, E., Tauber, E., and Kyriacou, C. P. (2006). Molecular genetics of the fruitfly circadian clock. Eur. J. Hum. Genet. 14, 729-73
43. Ruden, D. M., Chen, L., Possidente, D., Possidente, B., Rasouli, P., Wang, L., Lu, X., Garfinkel, M. D., Hirsch, H. V., and Page, G. P. (2009). Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead. Neurotoxicology 30, 898-91
44. Sandhir, R., and Gill, K. D. (1994a). Lead perturbs calmodulin dependent cyclic AMP metabolism in rat central nervous system. Biochem. Mol. Biol. Int. 33,729-74
45. Sandhir, R., and Gill, K. D. (1994b). Alterations in calcium homeostasis on lead exposure in rat synaptosomes. Mol. Cell. Biochem. 131, 25-3
46. Shaw, P. J., Cirelli, C., Greenspan, R. J., and Tononi, G. (2000). Correlates of sleep and waking in Drosophila melanogaster. Science 287, 1834-183
47. Singh, M. P., Ram, K. R., Mishra, M., Shrivastava, M., Saxena, D. K., and Chowdhuri, D. K. (2010). Effects of co-exposure of benzene, toluene and xylene to Drosophila melanogaster: alteration in hsp70, hsp60, hsp83, hsp26, ROS generation and oxidative stress markers. Chemosphere 79, 577-58
48. Smith, E. N., and Kruglyak, L. (2008). Gene-environment interaction in yeast gene expression. PLoS Biol. 6, e83. doi: 10.1371/journal.pbio. 0060083
49. Suhre, K., Shin, S.-Y., Petersen, A.-K., Mohney, R. P., Meredith, D., Wägele, B., A.-K., Altmaier, E., CARDIo-GRAM, Deloukas, P., Erdmann, J., Grundberg, E., Hammond, C. J., Hrabé de Angelis, M., Kastenmüller, G., Köttgen, A., Kronen-berg, F., Mangino, M., Meisinger, C., Meitinger, T., Mewes, H.-W., Milburn, M. V., Prehn, C., Raffler, J., Ried, J. S., Römisch-Margl, W., Samani, N. J., Small, K. S., Wichmann, H.-E., Zhai, G., Illig, T., Spector, T. D., Adamski, J., Soranzo, N., and Gieger, C. (2011). Human metabolic individuality in biomedical and pharmaceutical research. Nature 477, 54-6
50. Takahashi, J. S., Shimomura, K., and Kumar, V. (2008). Searching for genes underlying behavior: lessons from circadian rhythms. Science 322, 909-91
51. UNEP. (2010). Lead Exposure and Human Health. Nairobi: Chemicals Branch, Division of Technology, Industry and Economics, United Nations Environment Program. Available at: www.chem.unep.ch/pops/pdf/lead/leadexp.pdf [accessed January 3, 2012].
52. Von Mayersbach, H. (1975). Proceedings: Time-a key in experimental and practical medicine. Naunyn Schmiedebergs Arch. Pharmacol. 287(Suppl.), R10
53. West, M. A., Kim, K., Kliebenstein, D. J., van Leeuwen, H., Michel-more, R. W., Doerge, R. W., and St. Clair, D. A. (2007). Global eQTL mapping reveals the complex genetic architecture of transcript-level variation in Arabidopsis. Genetics 175, 1441-145
54. Xu, F., Hennessy, D. A., Lee, T. K. M., and Syed, N. I. (2009). Trophic factor-induced intracellular calcium oscillations are required for the expression of postsynaptic acetyl-choline receptors during synapse formation between Lymnaea neurons. J. Neurosci. 29,2167-217
55. Zhang, X., Huang, S., Sun, W., and Wang, W (2012). Rapid and robust resampling-based multiple testing correction with application in genome-wide eQTL study. Genetics. doi: 10.1534/genetics.111.137737
56. Zucker, R. S. (1996). Exocytosis: a molecular and physiological perspective. Neuron 17, 1049-105
57. Zucker, R.S., and Regehr, W.G. (2002). Short-termsynapticplasticity. Annu. Rev.Physiol. 64, 355-405.