Overnight Fasting Regulates Inhibitory Tone to Cholinergic Neurons of the Dorsomedial Nucleus of the Hypothalamus

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Groessl, Florian ^a,c   Jeong, Jae Hoon ^b   Talmage, David A ^a   Role, Lorna W ^a   Jo, Young Hwan ^b  

^a Stony Brook University   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE ACETYLTRANSFERASE; ENHANCED GREEN FLUORESCENT PROTEIN; PROTEIN FOS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELL FUNCTION; CELLULAR DISTRIBUTION; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; ENERGY BALANCE; FLUORESCENCE IMAGING; FOOD DEPRIVATION; GABAERGIC INHIBITION; GLUTAMATERGIC TRANSMISSION; IMMUNOCYTOCHEMISTRY; INTRACELLULAR SIGNALING; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL INHIBITION; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; NUTRIENT AVAILABILITY; PROTEIN EXPRESSION; PROTEIN INDUCTION; SENSITIVITY ANALYSIS; SYNAPTIC INHIBITION; UPREGULATION;

ANIMALS; CHOLINE O-ACETYLTRANSFERASE; CHOLINERGIC NEURONS; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; ENERGY METABOLISM; FASTING; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, GABA; RECEPTORS, GLUTAMATE; SYNAPTIC TRANSMISSION;

MUS;

EID: 84876021852     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060828     Document Type: Article

References (34)

1. Haslam DW, James WP, (2005) Obesity. Lancet 366: 1197-1209.
2. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG, (2000) Central nervous system control of food intake. Nature 404: 661-671.
3. Cone RD, (1999) The Central Melanocortin System and Energy Homeostasis. Trends Endocrinol Metab 10: 211-216.
4. Spiegelman BM, Flier JS, (2001) Obesity and the regulation of energy balance. Cell 104: 531-543.
5. Chao PT, Yang L, Aja S, Moran TH, Bi S, (2011) Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity. Cell Metab 13: 573-583.
6. Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, et al. (2003) Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci 23: 10691-10702.
7. Nakamura Y, Nakamura K, Matsumura K, Kobayashi S, Kaneko T, et al. (2005) Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus. Eur J Neurosci 22: 3137-3146.
8. Zhang Y, Kerman IA, Laque A, Nguyen P, Faouzi M, et al. (2011) Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci 31: 1873-1884.
9. Bellinger LL, Bernardis LL, (2002) The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: lessons learned from lesioning studies. Physiol Behav 76: 431-442.
10. Nakamura K, (2011) Central circuitries for body temperature regulation and fever. Am J Physiol Regul Integr Comp Physiol 301: R1207-1228.
11. Ulrich-Lai YM, Herman JP, (2009) Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 10: 397-409.
12. Vong L, Ye C, Yang Z, Choi B, Chua S Jr, et al. (2011) Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71: 142-154.
13. Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M, (2007) Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 27: 14265-14274.
14. Crosby KM, Inoue W, Pittman QJ, Bains JS, (2011) Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits. Neuron 71: 529-541.
15. Lee S, Bookout AL, Lee CE, Gautron L, Harper MJ, et al. (2012) Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus. J Comp Neurol 520: 3617-3632.
16. Jo YH, Talmage DA, Role LW, (2002) Nicotinic receptor-mediated effects on appetite and food intake. J Neurobiol 53: 618-632.
17. Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, et al. (2011) Nicotine decreases food intake through activation of POMC neurons. Science 332: 1330-1332.
18. Huang H, Xu Y, van den Pol AN, (2011) Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences. J Neurophysiol 106: 1191-1202.
19. Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, et al. (2001) Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 410: 207-212.
20. Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, et al. (2005) Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron 46: 297-308.
21. Thompson RH, Swanson LW, (1998) Organization of inputs to the dorsomedial nucleus of the hypothalamus: a reexamination with Fluorogold and PHAL in the rat. Brain Res Brain Res Rev 27: 89-118.
22. Grybko MJ, Hahm ET, Perrine W, Parnes JA, Chick WS, et al. (2011) A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons. Eur J Neurosci 33: 1786-1798.
23. Gooley JJ, Schomer A, Saper CB, (2006) The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nat Neurosci 9: 398-407.
24. Woolf NJ, (1991) Cholinergic systems in mammalian brain and spinal cord. Prog Neurobiol 37: 475-524.
25. Tago H, McGeer PL, Bruce G, Hersh LB, (1987) Distribution of choline acetyltransferase-containing neurons of the hypothalamus. Brain Res 415: 49-62.
26. Huo L, Grill HJ, Bjorbaek C, (2006) Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus. Diabetes 55: 567-573.
27. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, et al. (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411: 480-484.
28. Donato J Jr, Frazao R, Fukuda M, Vianna CR, Elias CF, (2010) Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons. Endocrinology 151: 5415-5427.
29. Kirkham TC, Williams CM, Fezza F, Di Marzo V, (2002) Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol 136: 550-557.
30. Di Marzo V, Matias I, (2005) Endocannabinoid control of food intake and energy balance. Nat Neurosci 8: 585-589.
31. Yoshida K, Li X, Cano G, Lazarus M, Saper CB, (2009) Parallel preoptic pathways for thermoregulation. J Neurosci 29: 11954-11964.
32. Rossi J, Balthasar N, Olson D, Scott M, Berglund E, et al. (2011) Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab 13: 195-204.
33. Gautron L, Lazarus M, Scott MM, Saper CB, Elmquist JK, (2010) Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach. J Comp Neurol 518: 2090-2108.
34. ter Horst GJ, Luiten PG, (1986) The projections of the dorsomedial hypothalamic nucleus in the rat. Brain Res Bull 16: 231-248.