Antifibrotic effects of CXCR4 antagonist in bleomycin-induced pulmonary fibrosis in mice

Journal of Medical Investigation

Volumn 60, Issue 1-2, 2013, Pages 127-137

  Makino, Hideki ^a   Aono, Yoshinori ^a   Azuma, Momoyo ^a   Kishi, Masami ^a   Yokota, Yuki ^a   Kinoshita, Katsuhiro ^a   Takezaki, Akio ^a   Kishi, Jun ^a   Kawano, Hiroshi ^a   Ogawa, Hirohisa ^a   Uehara, Hisanori ^a   Izumi, Keisuke ^a   Sone, Saburo ^a   Nishioka, Yasuhiko ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

AMD3100; CXCL12; CXCR4; Fibrocyte; Pulmonary fibrosis

Indexed keywords

BLEOMYCIN; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; COLLAGEN; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL TRANSPORT; CONTROLLED STUDY; DRUG DOSE COMPARISON; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LUNG FIBROSIS; LUNG LAVAGE; LYMPHOCYTE; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; RECEPTOR BLOCKING; WEIGHT REDUCTION;

MUS;

EID: 84876015454     PISSN: 13431420     EISSN: 13496867     Source Type: Journal    
DOI: 10.2152/jmi.60.127     Document Type: Article

References (31)

1. Gross TJ, Hunninghake GW: Idiopathic pulmonary fibrosis. N Engl J Med 345: 517-525, 2001
2. Selman M, King TE Jr, Pardo A: Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 134: 136-151, 2001
3. American Thoracic Society: Idiopathic pulmonary fibrosis: Diagnosis and treatment. International consensus statement. Am J Respir Crit Care Med 161: 646-664, 2000
4. Hashimoto N, Jin H, Liu T, Chensue SW, Phan SH: Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest 113: 243-252, 2004
5. Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, Belperio JA, Keane MP, Strieter RM: Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 114: 438-446, 2004
6. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA: Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 103: 13180-13185, 2006
7. Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z: Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 166: 1321-1332, 2005
8. Willis BC, du Bois RM, Borok Z: Epithelial origin of myofibroblasts during fibrosis in the lung. Proc Am Thorac Soc 3: 377-382, 2006
9. Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A: Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1: 71-81, 1994
10. Abe R, Donnelly SC, Peng T, Bucala R, Metz CN: Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 166: 7556-7562, 2001
11. Yang L, Scott PG, Giuffre J, Shankowsky HA, Ghahary A, Tredget EE: Peripheral blood fibrocytes from burn patients: identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells. Lab Invest 82: 1183-1192, 2002
12. Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S: Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 171: 380-389, 2003
13. Kisseleva T, Brenner DA: Fibrogenesis of parenchymal organs. Proc Am Thorac Soc 5: 338-342, 2008
14. Mehrad B, Burdick MD, Zisman DA, Keane MP, Belperio JA, Strieter RM: Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. Biochem Biophys Res Commun 353: 104-108, 2007
15. Andersson-Sjoland A, de Alba CG, Nihlberg K, Becerril C, Ramirez R, Pardo A, Westergren-Thorsson G, Selman M: Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis. Int J Biochem Cell Biol 40: 2129-2140, 2008
16. Moore BB, Kolodsick JE, Thannickal VJ, Cooke K, Moore TA, Hogaboam C, Wilke CA, Toews GB: CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol 166: 675-684, 2005
17. Moore BB, Murray L, Das A, Wilke CA, Herrygers AB, Toews GB: The role of CCL12 in the recruitment of fibrocytes and lung fibrosis. Am J Respir Cell Mol Biol 35: 175-181, 2006
18. Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, Matsushima K, Mukaida N: Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycininduced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Am J Pathol 170: 843-854, 2007
19. Aono Y, Nishioka Y, Inayama M, Ugai M, Kishi J, Uehara H, Izumi K, Sone S: Imatinib as a novel antifibrotic agent in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 171: 1279-1285, 2005
20. Harrison JH, Lazo JS: High dose continuous infusion of bleomycin in mice: a new model for drug-induced pulmonary fibrosis. J Pharmacol Exp Ther 243: 1185-1194, 1987
21. AzumaM, Nishioka Y, Aono Y, Inayama M, Makino H, Kishi J, Shono M, Kinoshita K, Uehara H, Ogushi F, Izumi K, Sone S: Role of alpha1-acid glycoprotein in therapeutic antifibrotic effects of imatinib with macrolides in mice. Am J Respir Crit Care Med 176: 1243-1250, 2007
22. Ashcroft T, Simpson JM, Timbrell V: Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 41: 467-470, 1988
23. Inayama M, Nishioka Y, Azuma M, Muto S, Aono Y, Makino H, Tani K, Uehara H, Izumi K, Itai A, Sone S: A novel IKB kinase-BBinhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 173: 1016-1022, 2006
24. Nishioka Y, Nishimura N, Suzuki Y, Sone S: Human monocyte-derived and CD83+ blood dendritic cells enhance NK cell-mediated cytotoxicity. Eur J Immunol 31: 2633-2641, 2001
25. Reikoff RA, Bucala R, Herzog EL: Fibrocytes: emerging effector cells in chronic inflammation. Nat Rev Immunol 11: 427-435, 2011
26. Yang IV, Burch LH, Steels MP, Savov JD, Hollingsworth JW, McElvania-Tekippe E, Berman KG, Speer MC, Sporn TA, Brown KK, Schwarz MI, Schwarz DA: Gene expression profiling of familial and sporadic interstitial pneumonia. Am J Respir Crit Care Med 175: 45-54, 2007
27. Hatse S, Princen K, Bridger G, Clercq ED, Schols D: Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS lett 527: 255-262, 2002
28. De Clercq E: The bicyclam AMD3100 story. Nat Rev Drug Discov 2: 581-587, 2003
29. Song JS, Kang CM, Kang HH, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH: Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis. Exp Mol Med 42: 465-476, 2010
30. Moeller A, Gilpin SE, Ask K, Cox G, Cook D, Gauldie J, Margetts PJ, Farkas L, Dobranowski J, Boylan C, O'Byrne PM, Strieter RM, Kolb M: Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 179: 588-594, 2009
31. Fujiwara A, Kobayashi H, Masuya M, Maruyama M, Nakamura S, Ibata H, Fujimoto H, Ohnishi M, Urawa M, Naito M, Takagi T, Kobayashi T, Gabazza EC, Takei Y, Taguchi O: Correlation between circulating fibrocytes, and activity and progression of interstitial lung diseases. Respirology 17; 693-698, 2012