Effect of iron supplementation on physical performance in children and adolescents: Systematic review of randomized controlled trials

Indian Pediatrics

Volumn 44, Issue 1, 2007, Pages 15-24

  Gera, Tarun ^a   Sachdev, H P S ^b,d   Nestel, Penelope ^c  

^a Sunder Lal Jain Hospital   (India)

^b SITARAM BHARTIA INSTITUTE OF SCIENCE AND RESEARCH   (India)

^c INTERNATIONAL FOOD POLICY RESEARCH INSTITUTE   (United States)

^d NONE   (India)

Author keywords

Anemia; Endurance time; Iron; Lactate; Meta analysis; Oxygen consumption; Physical performance

Indexed keywords

IRON; LACTIC ACID; PLACEBO;

ADOLESCENT; ARTIFICIAL MILK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ENDURANCE; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; LACTATE BLOOD LEVEL; MEDICAL LITERATURE; OXYGEN CONSUMPTION; PHYSICAL PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; REVIEW; SCHOOL CHILD; SYSTEMATIC REVIEW; TREADMILL EXERCISE; VITAMIN SUPPLEMENTATION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; EXERCISE TEST; HEART RATE; HUMANS; INFANT; INFANT, NEWBORN; IRON, DIETARY; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; PHYSICAL FITNESS; RANDOMIZED CONTROLLED TRIALS;

EID: 33846508454     PISSN: 00196061     EISSN: 00196061     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. United Nations Administrative Committee on Coordination Sub-Committee on Nutrition (ACC/SCN). Fourth Report on the World Nutrition Situation. Geneva: ACC/SCN in collaboration with International Food Policy Research Institute, 2000.
2. Singh P, Toteja GS. Micronutrient profile of Indian children and women: summary of available data for iron and vitamin A. Indian Pediatr 2003; 40:477-479.
3. Allen L, Casterline-Sabel J. Prevalence and causes of nutritional anemia. In: Nutritional Anemias. Ed. Ramakrishnan U. New York. CRC Press, 2001; p7-22.
4. Gledhill N, Warburton D, Jamnik V. Hemoglobin, blood volume, cardiac function and aerobic power. Can J Appl Physiol 1999; 24: 54-65.
5. Zhu Y, Haas JD. Iron depletion with anemia and physical performance in young women. Am J Clin Nutr 1997; 66: 334-341.
6. Levin HM. A benefit cost analysis of nutritional programs for anemia reduction. Res Observer 1986; 1: 219-225.
7. Edgerton VR, Ohira Y, Hettiarachi J, Senewiratne B, Gardner GW, Barnard RJ. Elevation of hemoglobin and work tolerance in iron-deficient subjects. J Nutr Sci Vitaminol 1981; 27: 77-86.
8. Newhouse IJ, Clement DB, Taunton JE, McKenzie DC. The effects of prelatent and latent iron deficiency on physical work capacity. Med Sci Sports Exercise 1989; 21: 263-268.
9. Juni P, Altman DG, Egger M. Assessing the quality of randomised controlled trials. In Systematic reviews in health care: Meta-analysis in context, editors Egger M, Smith GD, Altman DG. London, BMJ Books, 2001: pp 87-108.
10. Clarke M, Oxman AD (eds). Assessment of study quality. Cochrane Reviewers Handbook 4.1.1 [updated December 2000]. In: The Cochrane Library, Issue 1, 2001. Oxford: Update Software. Updated quarterly.
11. Follmann D, Elliott P, Suh I, Cutler J. Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol 1992; 45: 769-773.
12. Sterne JAC, Egger M, Smith GD. Investigating and dealing with publication and other biases. In: Systematic reviews in health care: Meta-analysis in context. Egger M, Smith GD, Altman DG (eds.). London, BMJ Books; 2001: pp 189-208.
13. Sterne JAC, Bradburn MJ, Egger M. Meta-analysis in STATA TM . In: Systematic reviews in health care: Meta-analysis in context. Egger M, Smith GD, Altman DG (eds.). London, BMJ Books; 2001: pp 347-369.
14. Powers HJ, Bates CJ, Downes R, Brubacher D, Sutcliffe V, Thurnhill A. Running performance in Gambian children: Effects of water soluble vitamins or iron. Eur J Clin Nutr 1988; 42: 895-902.
15. Gopaldas T, Kale M, Bhardwaj P. Prophylactic iron supplementation for underprivileged school boys III: Impact on submaximal work capacity. Indian Pediatr 1985; 22: 745-752.
16. Harahap H, Jahari AB, Husaini MA, Saco-Pollitt C, Pollitt E. Effects of an energy and micronutrient supplement on iron deficiency anemia, physical activity and motor and mental development in undernourished children in Indonesia. Eur J Clin Nutr 2000; 54 (Suppl 2): S114-119.
17. Seshadri S, Malhotra S. The effect of hematinics on the physical work capacity in anemics. Indian Pediatr 1984; 21: 529-533.
18. Ballin A, Berar M, Rubinstein U, Kleter Y, Hershkowitz A, Meytes D. Iron state in female adolescents. Am J Dis Child 1992; 146: 803-805.
19. Rowland TW, Deisroth MB, Green GM, Kelleher JF. The effect of iron therapy on exercise capacity of non-anemic iron deficient adolescent runners. Am J Dis Child 1988; 142: 165-169.
20. Friedmann BE, Weller E, Mairburl H, Bartsch P. Effects of iron repletion on blood volume and performance capacity in young athletes. Med Sci Sports Exerc 2001; 33: 741-746.
21. Davies CTM, Chukweumeka AC, Van Haaren JPM. Iron deficiency anemia: Its effect on maximum aerobic power and responses to exercise in African males aged 17-40 years. Clin Sci 1973; 44: 555-562.
22. Roach RC, Loskolou MD, Calbet JA, Saltin B. Arterial oxygen content and tension in regulation of cardiac output and leg blood flow during exercise in humans. Am J Physiol 1999; 276: H438-445.
23. Gardner GW, Edgerton V, Barnard RJ, Bernaucer EH. Cardiorespiratory, hematological and physical performance responses of anemic subjects to iron treatment. Am J Clin Nutr 1975; 28: 982-988.
24. Gardner GW, Edgerton V, Senewiratne B, Barnard R, Ohira Y. Physical work capacity and metabolic stress in subjects with iron deficiency anemia. Am J Clin Nutr 1977; 30: 910-917.
25. Oexle H, Gnaiger E, Weiss G. Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation. Biochim Biophys Acta. 1999;1413(3): 99-107.
26. Dallman PR. Biochemical basis for manifestations of iron deficiency. Ann Rev Nutr 1986; 6: 13-40.
27. Davies KJA, Donovan CM, Refino CJ, Brooks GA, Packer L, Dallman PR. Distinguishing effects of anemia and muscle iron deficiency on exercise bioenergetics in the rat. Am J Physiol 1984; 246: E535-E543.
28. Davies KJA, Marguire JJ, Brooks GA, Dallman PR, Packer L. Muscle mitochondrial bioenergetics, oxygen supply and work capacity during dietary iron deficiency and repletion. Am J Physiol 1982; 242: E418-427.
29. Perkkio MV, Jansson LT, Brooks GA, Refino CJ, Dallman PR. Work performance in iron deficiency of increasing severity. J Appl Physiol 1985; 58: 1477-1480.