Repression of exogenous gene expression by the retinoic acid target gene G0S2

International Journal of Oncology

Volumn 42, Issue 5, 2013, Pages 1743-1753

  Ma, Tian ^a   Dong, Jessica P ^c   Sekula, David J ^a   Fei, Dennis Liang ^a   Lamph, William W ^d   Henderson, Michael ^a   Lu, Yun ^a   Blumen, Steven ^a   Freemantle, Sarah J ^a   Dmitrovsky, Ethan ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^c DARTMOUTH COLLEGE   (United States)

^d Ligand Pharmaceutical   (United States)

Author keywords

G0 G1 switch gene 2; Retinoic acid; Transcriptional repression

Indexed keywords

G0 SWITCH PROTEIN 2; MEMBRANE PROTEIN; OLEIC ACID; RETINOIC ACID; RETINOIC ACID RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; EMBRYO; HUMAN; HUMAN CELL; HYDROPHOBICITY; LEUKEMIA CELL; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; TRANSCRIPTION REGULATION;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; LIPASE; RECEPTORS, RETINOIC ACID; RNA, SMALL INTERFERING; TRETINOIN; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84875981937     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1876     Document Type: Article

References (31)

1. Massaro D and Massaro GD: Lung development, lung function, and retinoids. New Eng J Med 362: 1829-1831, 2010.
2. Palczewski K: Chemistry and biology of vision. J Biol Chem 287: 1612-1619, 2012.
3. Pino-Lagos K, Benson MJ and Noelle RJ: Retinoic acid in the immune system. Ann NY Acad Sci 1143: 170-187, 2008.
4. Freemantle SJ, Spinella MJ and Dmitrovsky E: Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene 22: 7305-7315, 2003. (Pubitemid 37487162)
5. Warrell RP Jr, Frankel SR, Miller WH Jr, et al: Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). New Eng J Med 324: 1385-1393, 1991.
6. Kakizuka A, Miller WH Jr, Umesono K, et al: Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 66: 663-674, 1991. (Pubitemid 121001702)
7. Melnick A and Licht JD: Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93: 3167-3215, 1999. (Pubitemid 29220886)
8. Pitha-Rowe I, Petty WJ, Kitareewan S and Dmitrovsky E: Retinoid target genes in acute promyelocytic leukemia. Leukemia 17: 1723-1730, 2003. (Pubitemid 37185247)
9. Kitareewan S, Blumen S, Sekula D, et al: G0S2 is an all-trans-retinoic acid target gene. Int J Oncol 33: 397-404, 2008.
10. Tamayo P, Slonim D, Mesirov J, et al: Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci USA 96: 2907-2912, 1999. (Pubitemid 29148817)
11. Russell L and Forsdyke D: A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated. DNA Cell Biol 10: 581-591, 1991.
12. Zandbergen F, Mandard S, Escher P, et al: The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J 392: 313-324, 2005. (Pubitemid 41796520)
13. Yang X, Lu X, Lombès M, et al: The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab 11: 194-205, 2010.
14. Cristillo AD, Heximer SP, Russell L and Forsdyke DR: Cyclosporin A inhibits early mRNA expression of G0/G1 switch (G0S2) in cultured human blood mononuclear cells. DNA Cell Biol 16: 1449-1458, 1997. (Pubitemid 28070524)
15. Koczan D, Guthke R, Thiesen HJ, et al: Gene expression profiling of peripheral blood mononuclear leukocytes from psoriasis patients identifies new immune regulatory molecules. Euro J Dermatol 15: 251-257, 2005. (Pubitemid 41020851)
16. Nakamura N, Shimaoka Y, Tougan T, et al: Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. DNA Res 13: 169-183, 2006. (Pubitemid 44726367)
17. Kobayashi S, Ito A, Okuzaki D, et al: Expression profiling of PBMC-based diagnostic gene markers isolated from vasculitis patients. DNA Res 15: 253-265, 2008.
18. Tokumaru Y, Yamashita K, Osada M, et al: Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. Cancer Res 64: 5982-5987, 2004. (Pubitemid 39129394)
19. Chang X, Monitto CL, Demokan S, et al: Identification of hypermethylated genes associated with cisplatin resistance in human cancers. Cancer Res 70: 2870-2879, 2010.
20. Kusakabe M, Kutomi T, Watanabe K, et al: Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches. Int J Cancer 126: 1895-1902, 2010.
21. Kusakabe M, Watanabe K, Emoto N, et al: Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. Biochem Biophys Res Commun 390: 1283-1287, 2009.
22. Welch C, Santra MK, El-Assaad W, et al: Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2. Cancer Res 69: 6782-6789, 2009.
23. Boyle JO, Langenfeld J, Lonardo F, et al: Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. J Natl Cancer Inst 91: 373-379, 1999. (Pubitemid 29102338)
24. Spinella MJ, Freemantle SJ, Sekula D, Chang JH, Christie AJ and Dmitrovsky E: Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation. J Biol Chem 274: 22013-22018, 1999.
25. Liu X, Sempere LF, Galimberti F, et al: (2009) Uncovering growth-suppressive microRNAs in lung cancer. Clin Cancer Res 15: 1177-1183, 2009.
26. White KA, Yore MM, Deng D and Spinella MJ: Limiting effects of RIP140 in estrogen signaling: potential mediation of anti-estrogenic effects of retinoic acid. J Biol Chem 280: 7829-7835, 2005. (Pubitemid 40349678)
27. Kitareewan S, Pitha-Rowe I, Sekula D, et al: UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Proc Natl Acad Sci USA 99: 3806-3811, 2002. (Pubitemid 34252187)
28. Lee SB, Park JH, Woster PM, Casero RA Jr and Park MH: Suppression of exogenous gene expression by spermidine/spermine N1-acetyltransferase 1 (SSAT1) cotransfection. J Biol Chem 285: 15548-15556, 2010.
29. Zaiou M: Multifunctional antimicrobial peptides: therapeutic targets in several human diseases. J Mol Med 85: 317-329, 2007. (Pubitemid 46452258)
30. Sandgren S, Wittrup A, Cheng F, Jönsson M, Eklund E, Busch S and Belting M: The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis. J Biol Chem 279: 17951-17956, 2004. (Pubitemid 38568102)
31. Heckmann BL, Zhang X, Xie X and Liu J: The G0/G1 switch gene 2 (G0S2): regulating metabolism and beyond. Biochim Biophys Acta 1831: 276-281, 2013.