Detecting DNA Modifications from SMRT Sequencing Data by Modeling Sequence Context Dependence of Polymerase Kinetic

PLoS Computational Biology

Volumn 9, Issue 3, 2013, Pages

  Feng, Zhixing ^a,b   Fang, Gang ^c   Korlach, Jonas ^d   Clark, Tyson ^d   Luong, Khai ^d   Zhang, Xuegong ^a   Wong, Wing ^b   Schadt, Eric ^d,e  

^a TSINGHUA NATIONAL LABORATORY FOR INFORMATION SCIENCE AND TECHNOLOGY   (China)

^b STANFORD UNIVERSITY   (United States)

^c University of Minnesota   (United States)

^d PACIFIC BIOSCIENCES   (United States)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; DNA; DNA SEQUENCES; GENE ENCODING; HIERARCHICAL SYSTEMS; METHYLATION; REACTION KINETICS;

CONTEXT DEPENDENCES; DNA DAMAGES; DNA MODIFICATION; DNA POLYMERASE; HISTORICAL DATA; KINETICS RATES; LOCAL SEQUENCES; METHYLATION DAMAGE; REAL- TIME; SINGLE MOLECULE;

KINETICS;

6 N METHYLADENOSINE; DNA POLYMERASE; PLASMID DNA;

ACCURACY; ARTICLE; BAYES THEOREM; CONTROLLED STUDY; DNA MODIFICATION; DNA SEQUENCE; DNA STRUCTURE; DNA SYNTHESIS; ENZYME KINETICS; ESCHERICHIA COLI; GATC MOTIF; MYCOPLASMA PNEUMONIAE; NONHUMAN; RECEIVER OPERATING CHARACTERISTIC; SIGNAL NOISE RATIO; SINGLE MOLECULE REAL TIME SEQUENCING;

EID: 84875981516     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002935     Document Type: Article

References (10)

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