Relationship of cellular topoisomerase IIα inhibition to cytotoxicity and published genotoxicity of fluoroquinolone antibiotics in V79 cells

Chemico-Biological Interactions

Volumn 203, Issue 2, 2013, Pages 386-390

  Williams, Gary M ^a   Brunnemann, Klaus D ^a   Smart, Daniel J ^a   Molina, David ^a   Jeffrey, Alan M ^a   Duan, Jian Dong ^a   Krebsfaenger, Niels ^b   Kampkoetter, Andreas ^b   Schmuck, Gabriele ^c  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b BAYER AG   (Germany)

^c BAYER PHARMA AG   (Germany)

Author keywords

Clinafloxacin; Fluoroquinolone; Genotoxicity; Lomefloxacin; Topoisomerase II

Indexed keywords

CLINAFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); LOMEFLOXACIN; TOPOISOMERASE IIALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL COUNT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA PROTEIN COMPLEX; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME INHIBITION; GENOTOXICITY; NONHUMAN;

BACTERIA (MICROORGANISMS); CRICETULUS GRISEUS; EUKARYOTA; MAMMALIA;

EID: 84875968236     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.01.003     Document Type: Article

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