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Volumn 34, Issue 4, 2013, Pages 916-926

RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN RLIP76; KI 67 ANTIGEN; MESSENGER RNA; PROTEIN P53; RAC1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 84875947010     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs401     Document Type: Article
Times cited : (46)

References (44)
  • 1
    • 0033023072 scopus 로고    scopus 로고
    • New treatment strategies for malignant gliomas
    • Avgeropoulos,N.G. et al. (1999) New treatment strategies for malignant gliomas. Oncologist, 4, 209-224.
    • (1999) Oncologist , vol.4 , pp. 209-224
    • Avgeropoulos, N.G.1
  • 2
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp,R. et al. (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med., 352, 987-996.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 987-996
    • Stupp, R.1
  • 3
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen,P.Y. et al. (2008) Malignant gliomas in adults. N. Engl. J. Med., 359, 492-507.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 492-507
    • Wen, P.Y.1
  • 4
    • 77952555038 scopus 로고    scopus 로고
    • Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma
    • Van Meir,E.G. et al. (2010) Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma. CA Cancer J. Clin., 60, 166-193.
    • (2010) CA Cancer J. Clin. , vol.60 , pp. 166-193
    • Van Meir, E.G.1
  • 5
    • 0034622633 scopus 로고    scopus 로고
    • Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin
    • Awasthi,S. et al. (2000) Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. Biochemistry, 39, 9327-9334.
    • (2000) Biochemistry , vol.39 , pp. 9327-9334
    • Awasthi, S.1
  • 6
    • 0042023468 scopus 로고    scopus 로고
    • Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance
    • Awasthi,S. et al. (2003) Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance. Int. J. Cancer, 106, 635-646.
    • (2003) Int. J. Cancer , vol.106 , pp. 635-646
    • Awasthi, S.1
  • 8
    • 0032515966 scopus 로고    scopus 로고
    • ATP-dependent human erythrocyte glutathioneconjugate transporter. I. Purification, photoaffinity labeling, and kinetic characteristics of ATPase activity
    • Awasthi,S. et al. (1998) ATP-dependent human erythrocyte glutathioneconjugate transporter. I. Purification, photoaffinity labeling, and kinetic characteristics of ATPase activity. Biochemistry, 37, 5231-5238.
    • (1998) Biochemistry , vol.37 , pp. 5231-5238
    • Awasthi, S.1
  • 9
    • 0028180441 scopus 로고
    • Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein
    • Awasthi,S. et al. (1994) Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein. J. Clin. Invest., 93, 958-965.
    • (1994) J. Clin. Invest. , vol.93 , pp. 958-965
    • Awasthi, S.1
  • 10
    • 0042490545 scopus 로고    scopus 로고
    • Role of RLIP76 in lung cancer doxorubicin resistance: I The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells
    • Singhal,S.S. et al. (2003) Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. Int. J. Oncol., 22, 365-375.
    • (2003) Int. J. Oncol. , vol.22 , pp. 365-375
    • Singhal, S.S.1
  • 11
    • 13444291026 scopus 로고    scopus 로고
    • RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer
    • Stuckler,D. et al. (2005) RLIP76 transports vinorelbine and mediates drug resistance in non-small cell lung cancer. Cancer Res., 65, 991-998.
    • (2005) Cancer Res , vol.65 , pp. 991-998
    • Stuckler, D.1
  • 12
    • 13744251832 scopus 로고    scopus 로고
    • POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis
    • Yadav,S. et al. (2005) POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Biochem. Biophys. Res. Commun., 328, 1003-1009.
    • (2005) Biochem. Biophys. Res. Commun. , vol.328 , pp. 1003-1009
    • Yadav, S.1
  • 13
    • 0033038806 scopus 로고    scopus 로고
    • Cytocentrin is a Ral-binding protein involved in the assembly and function of the mitotic apparatus
    • Quaroni,A. et al. (1999) Cytocentrin is a Ral-binding protein involved in the assembly and function of the mitotic apparatus. J. Cell Sci., 112 (Pt 5), 707-718.
    • (1999) J. Cell Sci. , vol.112 , Issue.PART 5 , pp. 707-718
    • Quaroni, A.1
  • 14
    • 0042232500 scopus 로고    scopus 로고
    • RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis
    • Rosse,C. et al. (2003) RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. J. Biol. Chem., 278, 30597-30604.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30597-30604
    • Rosse, C.1
  • 15
    • 0041492605 scopus 로고    scopus 로고
    • Role of RLIP76 in lung cancer doxorubicin resistance: III Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity
    • Awasthi,S. et al. (2003) Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity. Int. J. Oncol., 22, 721-732.
    • (2003) Int. J. Oncol. , vol.22 , pp. 721-732
    • Awasthi, S.1
  • 16
    • 47149118163 scopus 로고    scopus 로고
    • Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immunemediated vascular diseases and atherosclerosis
    • Margutti,P. et al. (2008) Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immunemediated vascular diseases and atherosclerosis. Blood, 111, 4559-4570.
    • (2008) Blood , vol.111 , pp. 4559-4570
    • Margutti, P.1
  • 17
    • 0038268180 scopus 로고    scopus 로고
    • HSF-1 interacts with Ral-binding protein 1 in a stressresponsive, multiprotein complex with HSP90 in vivo
    • Hu,Y. et al. (2003) HSF-1 interacts with Ral-binding protein 1 in a stressresponsive, multiprotein complex with HSP90 in vivo. J. Biol. Chem., 278, 17299-17306.
    • (2003) J. Biol. Chem. , vol.278 , pp. 17299-17306
    • Hu, Y.1
  • 18
    • 0029588356 scopus 로고
    • A putative effector of Ral has homology to Rho/Rac GTPase activating proteins
    • Park,S.H. et al. (1995) A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene, 11, 2349-2355.
    • (1995) Oncogene , vol.11 , pp. 2349-2355
    • Park, S.H.1
  • 19
    • 33644530955 scopus 로고    scopus 로고
    • Regression of melanoma in a murine model by RLIP76 depletion
    • Singhal,S.S. et al. (2006) Regression of melanoma in a murine model by RLIP76 depletion. Cancer Res., 66, 2354-2360.
    • (2006) Cancer Res , vol.66 , pp. 2354-2360
    • Singhal, S.S.1
  • 20
    • 34249322665 scopus 로고    scopus 로고
    • Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1)
    • Singhal,S.S. et al. (2007) Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1). Cancer Res., 67, 4382-4389.
    • (2007) Cancer Res , vol.67 , pp. 4382-4389
    • Singhal, S.S.1
  • 21
    • 0035798564 scopus 로고    scopus 로고
    • Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST 8 is an early adaptive response of cells to heat and oxidative stress
    • Cheng,J.Z. et al. (2001) Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress. J. Biol. Chem., 276, 41213-41223.
    • (2001) J. Biol. Chem. , vol.276 , pp. 41213-41223
    • Cheng, J.Z.1
  • 22
    • 0029001797 scopus 로고
    • Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases
    • Cantor,S.B. et al. (1995) Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Mol. Cell. Biol., 15, 4578-4584.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4578-4584
    • Cantor, S.B.1
  • 23
    • 0029089074 scopus 로고
    • Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity
    • Jullien-Flores,V. et al. (1995) Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J. Biol. Chem., 270, 22473-22477.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22473-22477
    • Jullien-Flores, V.1
  • 24
    • 0036531793 scopus 로고    scopus 로고
    • Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes
    • Senger,D.L. et al. (2002) Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes. Cancer Res., 62, 2131-2140.
    • (2002) Cancer Res , vol.62 , pp. 2131-2140
    • Senger, D.L.1
  • 25
    • 34249018367 scopus 로고    scopus 로고
    • GEFs and GAPs: critical elements in the control of small G proteins
    • Bos,J.L. et al. (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell, 129, 865-877.
    • (2007) Cell , vol.129 , pp. 865-877
    • Bos, J.L.1
  • 26
    • 4143097230 scopus 로고    scopus 로고
    • Isotype-specific degradation of Rac activated by the cytotoxic necrotizing factor 1
    • Pop,M. et al. (2004) Isotype-specific degradation of Rac activated by the cytotoxic necrotizing factor 1. J. Biol. Chem., 279, 35840-35848.
    • (2004) J. Biol. Chem. , vol.279 , pp. 35840-35848
    • Pop, M.1
  • 27
    • 33745753386 scopus 로고    scopus 로고
    • Proteasome-mediated degradation of Rac1-GTP during epithelial cell scattering
    • Lynch,E.A. et al. (2006) Proteasome-mediated degradation of Rac1-GTP during epithelial cell scattering. Mol. Biol. Cell, 17, 2236-2242.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 2236-2242
    • Lynch, E.A.1
  • 28
    • 84857064430 scopus 로고    scopus 로고
    • Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells
    • Wang,J. et al. (2012) Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells. J. Neurooncol., 106, 473-484.
    • (2012) J. Neurooncol. , vol.106 , pp. 473-484
    • Wang, J.1
  • 29
    • 84861322358 scopus 로고    scopus 로고
    • The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector
    • Neel,N.F. et al. (2012) The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector. Mol. Cell. Biol., 32, 1374-1386.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 1374-1386
    • Neel, N.F.1
  • 30
    • 36549018217 scopus 로고    scopus 로고
    • Recruitment of Cdc42 through the GAP domain of RLIP participates in remodeling of the actin cytoskeleton and is involved in Xenopus gastrulation
    • Boissel,L. et al. (2007) Recruitment of Cdc42 through the GAP domain of RLIP participates in remodeling of the actin cytoskeleton and is involved in Xenopus gastrulation. Dev. Biol., 312, 331-343.
    • (2007) Dev. Biol. , vol.312 , pp. 331-343
    • Boissel, L.1
  • 31
    • 4444221607 scopus 로고    scopus 로고
    • Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo
    • Murray,N.R. et al. (2004) Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo. J. Cell Biol., 164, 797-802.
    • (2004) J. Cell Biol. , vol.164 , pp. 797-802
    • Murray, N.R.1
  • 32
    • 32944470373 scopus 로고    scopus 로고
    • A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells
    • Stallings-Mann,M. et al. (2006) A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells. Cancer Res., 66, 1767-1774.
    • (2006) Cancer Res , vol.66 , pp. 1767-1774
    • Stallings-Mann, M.1
  • 33
    • 33845659888 scopus 로고    scopus 로고
    • Antagonizing inactivated tumor suppressor genes and activated oncogenes by a versatile transgenesis system: application in mantle cell lymphoma
    • Pscherer,A. et al. (2006) Antagonizing inactivated tumor suppressor genes and activated oncogenes by a versatile transgenesis system: application in mantle cell lymphoma. FASEB J., 20, 1188-1190.
    • (2006) FASEB J , vol.20 , pp. 1188-1190
    • Pscherer, A.1
  • 34
    • 29244454269 scopus 로고    scopus 로고
    • Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis
    • Nawrocki,S.T. et al. (2005) Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. Cancer Res., 65, 11658-11666.
    • (2005) Cancer Res , vol.65 , pp. 11658-11666
    • Nawrocki, S.T.1
  • 36
    • 79960039507 scopus 로고    scopus 로고
    • Colen,C.B. et al. (2011) Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study. Neoplasia, 13, 620-632.
    • (2011) Neoplasia , vol.13 , pp. 620-632
    • Colen, C.B.1
  • 37
    • 42549127895 scopus 로고    scopus 로고
    • Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon
    • Calcagno,S.R. et al. (2008) Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon. Int. J. Cancer, 122, 2462-2470.
    • (2008) Int. J. Cancer , vol.122 , pp. 2462-2470
    • Calcagno, S.R.1
  • 38
    • 60649110014 scopus 로고    scopus 로고
    • Regression of prostate cancer xenografts by RLIP76 depletion
    • Singhal,S.S. et al. (2009) Regression of prostate cancer xenografts by RLIP76 depletion. Biochem. Pharmacol., 77, 1074-1083.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 1074-1083
    • Singhal, S.S.1
  • 39
    • 55849137106 scopus 로고    scopus 로고
    • RACK1 functions in rice innate immunity by interacting with the Rac1 immune complex
    • Nakashima,A. et al. (2008) RACK1 functions in rice innate immunity by interacting with the Rac1 immune complex. Plant Cell, 20, 2265-2279.
    • (2008) Plant Cell , vol.20 , pp. 2265-2279
    • Nakashima, A.1
  • 40
    • 79957862487 scopus 로고    scopus 로고
    • Targeting p53-null neuroblastomas through RLIP76
    • Singhal,J. et al. (2011) Targeting p53-null neuroblastomas through RLIP76. Cancer Prev. Res. (Phila.), 4, 879-889.
    • (2011) Cancer Prev. Res. (Phila.) , vol.4 , pp. 879-889
    • Singhal, J.1
  • 41
    • 66249146631 scopus 로고    scopus 로고
    • RLIP76: a target for kidney cancer therapy
    • Singhal,S.S. et al. (2009) RLIP76: a target for kidney cancer therapy. Cancer Res., 69, 4244-4251.
    • (2009) Cancer Res , vol.69 , pp. 4244-4251
    • Singhal, S.S.1
  • 42
    • 84861322358 scopus 로고    scopus 로고
    • The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector
    • Neel,N.F. et al. (2012) The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector. Mol. Cell. Biol., 32, 1374-1386.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 1374-1386
    • Neel, N.F.1
  • 43
    • 0035799333 scopus 로고    scopus 로고
    • Functional reassembly of ATP-dependent xenobiotic transport by the N- and C-terminal domains of RLIP76 and identification of ATP binding sequences
    • Awasthi,S. et al. (2001) Functional reassembly of ATP-dependent xenobiotic transport by the N- and C-terminal domains of RLIP76 and identification of ATP binding sequences. Biochemistry, 40, 4159-4168.
    • (2001) Biochemistry , vol.40 , pp. 4159-4168
    • Awasthi, S.1
  • 44
    • 36549018217 scopus 로고    scopus 로고
    • Recruitment of Cdc42 through the GAP domain of RLIP participates in remodeling of the actin cytoskeleton and is involved in Xenopus gastrulation
    • Boissel,L. et al. (2007) Recruitment of Cdc42 through the GAP domain of RLIP participates in remodeling of the actin cytoskeleton and is involved in Xenopus gastrulation. Dev. Biol., 312, 331-343.
    • (2007) Dev. Biol. , vol.312 , pp. 331-343
    • Boissel, L.1


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