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Volumn 6, Issue 2, 2013, Pages 191-203

The current status and future impact of targeted therapies in non-Hodgkin lymphoma

Author keywords

antibody drug conjugate; bispecific T cell engager molecules; Hodgkin lymphoma; immunomodulatory agent; monoclonal antibody; non Hodgkin lymphoma; radioimmunotherapy; small molecule kinase inhibitor; targeted therapy

Indexed keywords

ALEMTUZUMAB; BENDAMUSTINE; BLEOMYCIN; BRENTUXIMAB VEDOTIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOTOXIN; DACARBAZINE; DEXAMETHASONE; DOXORUBICIN; EPRATUZUMAB; FLUDARABINE; IBRITUMOMAB TIUXETAN; IFOSFAMIDE; INOTUZUMAB OZOGAMICIN; MEDI 551; MOGAMULIZUMAB; MONOCLONAL ANTIBODY; OBINUTUZUMAB; OFATUMUMAB; PIDILIZUMAB; PREDNISONE; RADIOISOTOPE; RITUXIMAB; TEMSIROLIMUS; TOSITUMOMAB I 131; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

EID: 84875945486     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/ehm.13.6     Document Type: Review
Times cited : (19)

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    • Younes A, Gordon L, Kim S et al. Phase I multi-dose escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous (IV) infusion every 3 weeks to patients with relapsed/ refractory B-cell non-Hodgkin's lymphoma (NHL). Blood (ASH Annual Meeting Abstracts) 114, Abstract 585 (2009).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Younes, A.1    Gordon, L.2    Kim, S.3
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    • A Phase I study of the anti-CD79b antibodyYdrug conjugate (ADC) DCDS4501A targeting CD79b in relapsed or refractory B-cell non-Hodgkin's lymphoma
    • Abstract 56
    • Palanca-Wessels M, Flinn I, Sehn L et al. A Phase I study of the anti-CD79b antibodyYdrug conjugate (ADC) DCDS4501A targeting CD79b in relapsed or refractory B-cell non-Hodgkin's lymphoma. Blood (ASH Annual Meeting Abstracts) 120, Abstract 56 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Palanca-Wessels, M.1    Flinn, I.2    Sehn, L.3
  • 43
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    • A Phase I study of DCDT2980S, an antibodyYdrug conjugate (ADC) targeting CD22, in relapsed or refractory B-cell non-Hodgkin's lymphoma
    • Abstract 59
    • Advani R, Lebovic D, Brunvand M et al. A Phase I study of DCDT2980S, an antibodyYdrug conjugate (ADC) targeting CD22, in relapsed or refractory B-cell non-Hodgkin's lymphoma. Blood (ASH Annual Meeting Abstracts) 120, Abstract 59 (2012).
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    • Advani, R.1    Lebovic, D.2    Brunvand, M.3
  • 44
    • 84867857964 scopus 로고    scopus 로고
    • Blinatumomab monotherapy shows effi cacy in patients with relapsed diffuse large B cell lymphoma
    • Abstract 1637
    • Viardot A, Goebeler M, Noppeney R et al. Blinatumomab monotherapy shows effi cacy in patients with relapsed diffuse large B cell lymphoma. Blood (ASH Annual Meeting Abstracts) 118, Abstract 1637 (2011).
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118
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    • 84875957334 scopus 로고    scopus 로고
    • Transient laboratory fi ndings upon fi rst dosing with T-cell engaging BiTE ® antibody blinatumomab in non-Hodgkin lymphoma patients
    • Abstract 4798
    • Nagorsen D, Zugmaier G, Kufer P et al. Transient laboratory fi ndings upon fi rst dosing with T-cell engaging BiTE ® antibody blinatumomab in non-Hodgkin lymphoma patients. Blood (ASH Annual Meeting Abstracts) 114, Abstract 4798 (2009).
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    • Nagorsen, D.1    Zugmaier, G.2    Kufer, P.3
  • 46
    • 84871491706 scopus 로고    scopus 로고
    • Long-term follow-up of hematologic relapsefree survival in a Phase 2 study of blinatumomab in patients with MRD in B-lineage ALL
    • Topp MS, Gökbuget N, Zugmaier G et al. Long-term follow-up of hematologic relapsefree survival in a Phase 2 study of blinatumomab in patients with MRD in B-lineage ALL. Blood 120 (26), 5185-5187 (2012).
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    • Topp, M.S.1    Gökbuget, N.2    Zugmaier, G.3
  • 47
    • 73949145763 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma
    • Witzig TE, Wiernik PH, Moore T et al. Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma. J. Clin. Oncol. 27 (32), 5404-5409 (2009).
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    • Witzig, T.E.1    Wiernik, P.H.2    Moore, T.3
  • 48
    • 84868193664 scopus 로고    scopus 로고
    • CALGB 50401: A randomized trial of lenalidomide alone versus lenalidomide plus rituximab in patients with recurrent FL
    • Abstract 8000
    • Leonard J, Jung S, Johnson J et al. CALGB 50401: A randomized trial of lenalidomide alone versus lenalidomide plus rituximab in patients with recurrent FL. J. Clin. Oncol. (ASCO Annual Meeting Abstracts) 30 (15), Abstract 8000 (2012).
    • (2012) J. Clin. Oncol. (ASCO Annual Meeting Abstracts) , vol.30 , Issue.15
    • Leonard, J.1    Jung, S.2    Johnson, J.3
  • 49
    • 84875922053 scopus 로고    scopus 로고
    • Lenalidomide and rituximab for untreated indolent lymphoma: Fi nal results of a Phase II study
    • Abstract 901
    • Fowler H, Neelapu S, Hagemeister F et al. Lenalidomide and rituximab for untreated indolent lymphoma: Fi nal results of a Phase II study. Blood (ASH Annual Meeting Abstracts) 120, Abstract 901 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Fowler, H.1    Neelapu, S.2    Hagemeister, F.3
  • 50
    • 64149112784 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma
    • Habermann TM, Lossos IS, Justice G et al. Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma. Br. J. Haematol. 145 (3), 344-349 (2009).
    • (2009) Br. J. Haematol. , vol.145 , Issue.3 , pp. 344-349
    • Habermann, T.M.1    Lossos, I.S.2    Justice, G.3
  • 51
    • 84875921698 scopus 로고    scopus 로고
    • Salvage therapy with bortezomib plus lenalidomide for relapsed/refractory mantle cell lymphoma: Initial results of a Phase II trial (Alliance/CALGB 50501)
    • Abstract 3696
    • Morrison V, Jung S. Johnson J et al. Salvage therapy with bortezomib plus lenalidomide for relapsed/refractory mantle cell lymphoma: Initial results of a Phase II trial (Alliance/CALGB 50501). Blood (ASH Annual Meeting Abstracts) 120, Abstract 3696 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Morrison, V.1    Jung, S.2    Johnson, J.3
  • 52
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    • Lenalidomide in combination with rituximab for patients with relapsed or refractory mantle-cell lymphoma: A Phase 1/2 clinical trial
    • Wang M, Fayad L, Wagner-Bartak N et al. Lenalidomide in combination with rituximab for patients with relapsed or refractory mantle-cell lymphoma: A Phase 1/2 clinical trial. Lancet Oncol. 13 (7), 716-723 (2012).
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    • Wang, M.1    Fayad, L.2    Wagner-Bartak, N.3
  • 53
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    • Potential synergic effect of lenalidomide-rituximab combination: Durable complete remissions in refractory diffuse large B cell lymphoma
    • Abstract 4989
    • Ivanov V, Coso D, Aurran-Schleinitz T et al Potential synergic effect of lenalidomide-rituximab combination: Durable complete remissions in refractory diffuse large B cell lymphoma. Blood (ASH Annual Meeting Abstracts) 118, Abstract 4989 (2011).
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118
    • Ivanov, V.1    Coso, D.2    Aurran-Schleinitz, T.3
  • 54
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    • Lenalidomide can be safely combined with R-CHOP (R2CHOP) in the initial chemotherapy for aggressive B-cell lymphomas: Phase I study
    • Nowakowski GS, LaPlant B, Habermann TM et al. Lenalidomide can be safely combined with R-CHOP (R2CHOP) in the initial chemotherapy for aggressive B-cell lymphomas: Phase I study. Leukemia 25 (12), 1877-1881 (2011).
    • (2011) Leukemia , vol.25 , Issue.12 , pp. 1877-1881
    • Nowakowski, G.S.1    LaPlant, B.2    Habermann, T.M.3
  • 55
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    • Activity of lenalidomide in a Phase II trial for T-cell lymphoma: Report on the fi rst 24 cases
    • Abstract 8524
    • Dueck G, Chua N, Prasad A et al. Activity of lenalidomide in a Phase II trial for T-cell lymphoma: Report on the fi rst 24 cases. J. Clin. Oncol. (ASCO Annual Meeting Abstracts) 27 (15), Abstract 8524 (2009).
    • (2009) J. Clin. Oncol. (ASCO Annual Meeting Abstracts) , vol.27 , Issue.15
    • Dueck, G.1    Chua, N.2    Prasad, A.3
  • 56
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    • A Phase 2 multicenter study of continuous dose lenalidomide in relapsed or refractory classical Hodgkin lymphoma
    • Abstract 1623
    • Fehniger T, Larson S, Trinkaus K et al. A Phase 2 multicenter study of continuous dose lenalidomide in relapsed or refractory classical Hodgkin lymphoma. Blood (ASH Annual Meeting Abstracts) 120, Abstract 1623 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Fehniger, T.1    Larson, S.2    Trinkaus, K.3
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    • Inhibition of Syk with fostamatinib disodium has signifi cant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
    • Friedberg JW, Sharman J, Sweetenham J et al. Inhibition of Syk with fostamatinib disodium has signifi cant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood 115 (13), 2578-2585 (2010).
    • (2010) Blood , vol.115 , Issue.13 , pp. 2578-2585
    • Friedberg, J.W.1    Sharman, J.2    Sweetenham, J.3
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    • Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has signifi cant activity in patients with relapsed/refractory B-cell malignancies
    • Advani RH, Buggy JJ, Sharman JP et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has signifi cant activity in patients with relapsed/refractory B-cell malignancies. J. Clin. Oncol. 31 (1), 88-94 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.1 , pp. 88-94
    • Advani, R.H.1    Buggy, J.J.2    Sharman, J.P.3
  • 59
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    • The Bruton's tyrosine kinase inhibitor ibrutinib (PCI-32765) is active and tolerated in relapsed follicular lymphoma
    • Abstract 156
    • Fowler N, Advani R, Sharman J et al. The Bruton's tyrosine kinase inhibitor ibrutinib (PCI-32765) is active and tolerated in relapsed follicular lymphoma. Blood (ASH Annual Meeting Abstracts) 120, Abstract 156 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Fowler, N.1    Advani, R.2    Sharman, J.3
  • 60
    • 84875146304 scopus 로고    scopus 로고
    • Interim results of an international, multicenter, Phase 2 study of Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib (PCI-32765), in relapsed or refractory mantle cell lymphoma (MCL): Durable effi cacy and tolerability with longer follow-up
    • Abstract 904
    • Wang L, Rule S, Martin P et al. Interim results of an international, multicenter, Phase 2 study of Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib (PCI-32765), in relapsed or refractory mantle cell lymphoma (MCL): Durable effi cacy and tolerability with longer follow-up. Blood (ASH Annual Meeting Abstracts) 120, Abstract 904 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Wang, L.1    Rule, S.2    Martin, P.3
  • 61
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    • The Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib (PCI-32765), has preferential activity in the ABC subtype of relapsed/refractory de novo diffuse large B-cell lymphoma (DLBCL): Interim results of a multicenter, open-label, Phase 2 study
    • Abstract 686
    • Wilson W, Gerecitano J, Goy A et al. The Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib (PCI-32765), has preferential activity in the ABC subtype of relapsed/refractory de novo diffuse large B-cell lymphoma (DLBCL): Interim results of a multicenter, open-label, Phase 2 study. Blood (ASH Annual Meeting Abstracts) 120, Abstract 686 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Wilson, W.1    Gerecitano, J.2    Goy, A.3
  • 62
    • 84875199467 scopus 로고    scopus 로고
    • The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (PCI-32765) promotes high response rate, durable remissions, and is tolerable in treatment naive (TN) and relapsed or refractory (RR) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) patients including patients with high-risk (HR) disease: New and updated results of 116 patients in a Phase Ib/II study
    • Abstract 189
    • Byrd J, Furman R, Coutre S et al. The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (PCI-32765) promotes high response rate, durable remissions, and is tolerable in treatment naive (TN) and relapsed or refractory (RR) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) patients including patients with high-risk (HR) disease: New and updated results of 116 patients in a Phase Ib/II study. Blood (ASH Annual Meeting Abstracts) 120, Abstract 189 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Byrd, J.1    Furman, R.2    Coutre, S.3
  • 63
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    • A Phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and related diseases
    • Abstract 6508
    • Jaglowski S, Jones J, Flynn J et al. A Phase Ib/II study evaluating activity and tolerability of BTK inhibitor PCI-32765 and ofatumumab in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and related diseases. J. Clin. Oncol. (ASCO Annual Meeting Abstracts) 30 (15), Abstract 6508 (2012).
    • (2012) J. Clin. Oncol. (ASCO Annual Meeting Abstracts) , vol.30 , Issue.15
    • Jaglowski, S.1    Jones, J.2    Flynn, J.3
  • 64
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    • Combination of the Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 with bendamustine (B)/rituximab (R) (BR) in patients (pts) with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL): Interim results of a Phase Ib/II study
    • Abstract 6515
    • O'Brien S, Barrientos J, Flinn I et al. Combination of the Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 with bendamustine (B)/rituximab (R) (BR) in patients (pts) with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL): Interim results of a Phase Ib/II study. J. Clin. Oncol. (ASCO Annual Meeting Abstracts). 30 (15), Abstract 6515 (2012).
    • (2012) J. Clin. Oncol. (ASCO Annual Meeting Abstracts). , vol.30 , Issue.15
    • O'Brien, S.1    Barrientos, J.2    Flinn, I.3
  • 65
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    • Phase Ib trial of AVL-292, a covalent inhibitor of Bruton's tyrosine kinase (BTK), in chronic lymphocytic leukemia (CLL) and B-non-Hodgkin lymphoma (B-NHL)
    • (ASCO Annual Meeting Abstracts)
    • Brown J, Sharman J, Harb W et al. Phase Ib trial of AVL-292, a covalent inhibitor of Bruton's tyrosine kinase (BTK), in chronic lymphocytic leukemia (CLL) and B-non-Hodgkin lymphoma (B-NHL). J. Clin. Oncol. (ASCO Annual Meeting Abstracts) 30 (15), 8032 (2012).
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    • Brown, J.1    Sharman, J.2    Harb, W.3
  • 66
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    • Clinical safety and activity in a Phase 1 study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase p110δ, in patients with relapsed or refractory non-Hodgkin lymphoma
    • Abstract 1777
    • Kahl B, Byrd J, Flinn I et al. Clinical safety and activity in a Phase 1 study of CAL-101, an isoform-selective inhibitor of phosphatidylinositol 3-kinase p110δ, in patients with relapsed or refractory non-Hodgkin lymphoma. Blood (ASH Annual Meeting Abstracts) 116, Abstract 1777 (2010).
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116
    • Kahl, B.1    Byrd, J.2    Flinn, I.3
  • 67
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    • Combinations of the phosphatidylinositol 3-kinase-delta (PI3Kδ) inhibitor Gs-1101 (CAL-101) with rituximab and/or bendamustine are tolerable and highly active in previously treated, indolent non-Hodgkin lymphoma: Results from a Phase I study
    • Abstract 3645
    • Fowler N, De Vos S, Marshall T et al. Combinations of the phosphatidylinositol 3-kinase-delta (PI3Kδ) inhibitor Gs-1101 (CAL-101) with rituximab and/or bendamustine are tolerable and highly active in previously treated, indolent non-Hodgkin lymphoma: Results from a Phase I study. Blood (ASH Annual Meeting Abstracts) 120, Abstract 3645 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Fowler, N.1    De Vos, S.2    Marshall, T.3
  • 68
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    • Combinations of the selective phosphatidylinositol 3-kinase-delta (PI3Kdelta) inhibitor GSY1101 (CAL-101) with rituximab and/or bendamustine are tolerable and highly active in patients with relapsed or refractory chronic lymphocytic leukemia (CLL): Results from a Phase I study
    • Abstract 191
    • Coutre S, Leonard J, Furman R et al. Combinations of the selective phosphatidylinositol 3-kinase-delta (PI3Kdelta) inhibitor GSY1101 (CAL-101) with rituximab and/or bendamustine are tolerable and highly active in patients with relapsed or refractory chronic lymphocytic leukemia (CLL): Results from a Phase I study. Blood (ASH Annual Meeting Abstracts) 120, Abstract 191 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Coutre, S.1    Leonard, J.2    Furman, R.3
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    • PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma
    • Meadows SA, Vega F, Kashishian A et al. PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma. Blood 119 (8), 1897-1900 (2012).
    • (2012) Blood , vol.119 , Issue.8
    • Meadows, S.A.1    Vega, F.2    Kashishian, A.3
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    • Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: The University of Chicago Phase II consortium
    • Smith SM, van Besien K, Karrison T et al. Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: The University of Chicago Phase II consortium. J. Clin. Oncol. 28 (31), 4740-4746 (2010).
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    • Low-dose, single-Agent temsirolimus for relapsed mantle cell lymphoma: A phase 2 trial in the north central cancer treatment group
    • Ansell SM, Inwards DJ, Rowland KM Jr et al. Low-dose, single-Agent temsirolimus for relapsed mantle cell lymphoma: A Phase 2 trial in the North Central Cancer Treatment Group. Cancer 113 (3), 508-514 (2008).
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    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • Hess G, Herbrecht R, Romaguera J et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J. Clin. Oncol. 27 (23), 3822-3829 (2009).
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    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3
  • 73
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    • A Phase II trial of oral mTOR inhibitor everolimus in relapsed aggressive non-Hodgkin lymphoma
    • Abstract 121
    • Reeder C, Gornet M, Habermann T et al. A Phase II trial of oral mTOR inhibitor everolimus in relapsed aggressive non-Hodgkin lymphoma. Blood (ASH Annual Meeting Abstracts) 110, Abstract 121 (2007).
    • (2007) Blood (ASH Annual Meeting Abstracts) , vol.110
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    • Everolimus for relapsed/refractory classical Hodgkin lymphoma: Multicenter, open-label, single-Arm, Phase 2 study
    • Abstract 2740
    • Johnston P, Pinter-Brown L, Rogerio J et al. Everolimus for relapsed/refractory classical Hodgkin lymphoma: Multicenter, open-label, single-Arm, Phase 2 study. Blood (ASH Annual Meeting Abstracts) 120, Abstract 2740 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Johnston, P.1    Pinter-Brown, L.2    Rogerio, J.3
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    • Pillar-1: Multicenter Phase 2 study of everolimus for patients with mantle cell lymphoma who are refractory or intolerant to bortezomib
    • Abstract 2751
    • Wang M, Popplewell L, Collins R et al. Pillar-1: Multicenter Phase 2 study of everolimus for patients with mantle cell lymphoma who are refractory or intolerant to bortezomib. Blood (ASH Annual Meeting Abstracts) 120, Abstract 2751 (2012).
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Wang, M.1    Popplewell, L.2    Collins, R.3
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    • Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: A Phase 2 study
    • Ansell SM, Tang H, Kurtin PJ et al. Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: A Phase 2 study. Lancet Oncol. 12 (4), 361-368 (2011).
    • (2011) Lancet Oncol. , vol.12 , Issue.4 , pp. 361-368
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    • Temsirolimus in combination with bendamustine and rituximab for the treatment of relapsed mantle cell and FL
    • Abstract 2697
    • Hess G, Keller U, Atta J et al Temsirolimus in combination with bendamustine and rituximab for the treatment of relapsed mantle cell and FL. Blood (ASH Annual Meeting Abstracts) 118, Abstract 2697 (2011).
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118
    • Hess, G.1    Keller, U.2    Atta, J.3
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    • Phase I study of mTOR inhibitor everolimus plus CHOP in patients with advanced, aggressive T-cell lymphomas
    • Abstract 1642
    • Kim S, Kang H, Kim J et al. Phase I study of mTOR inhibitor everolimus plus CHOP in patients with advanced, aggressive T-cell lymphomas. Blood (ASH Annual Meeting Abstracts) 118, Abstract 1642 (2011).
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    • Kim, S.1    Kang, H.2    Kim, J.3
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    • Phase 2 trial of alisertib, an investigational, potent inhibitor of Aurora A kinase in patients with aggressive B and T-cell non-Hodgkin lymphoma
    • Abstract 95
    • Friedberg L, Mahadevan D, Jung J et al. Phase 2 trial of alisertib, an investigational, potent inhibitor of Aurora A kinase in patients with aggressive B and T-cell non-Hodgkin lymphoma. Blood (ASH Annual Meeting Abstracts) 118, Abstract 95 (2011).
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118
    • Friedberg, L.1    Mahadevan, D.2    Jung, J.3
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    • Phase III study of investigational MLN8237 (alisertib) versus investigator's choice in patients (pts) with relapsed/refractory (rel/ref) peripheral T-cell lymphoma (PTCL)
    • O'Connor O, Leonard EJ, Benaim E. Phase III study of investigational MLN8237 (alisertib) versus investigator's choice in patients (pts) with relapsed/refractory (rel/ref) peripheral T-cell lymphoma (PTCL). J. Clin. Oncol. (ASCO Annual Meeting Abstracts) 30 (15), TPS8110 (2012).
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    • Phase I/II study of investigational agent MLN8237 (alisertib) plus rituximab with or without vincristine in patients (pts) with relapsed/refractory (rel/ref) aggressive diffuse large B-cell lymphoma (DLBCL)/transformed FL (TFL)
    • (ASCO Annual Meeting Abstracts)
    • Persky D, Kelly K, Lee P et al. Phase I/II study of investigational agent MLN8237 (alisertib) plus rituximab with or without vincristine in patients (pts) with relapsed/refractory (rel/ref) aggressive diffuse large B-cell lymphoma (DLBCL)/transformed FL (TFL). J. Clin. Oncol. (ASCO Annual Meeting Abstracts) 30 (15), TPS8109 (2012).
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