Reduction of cortical GABAergic inhibition correlates with working memory impairment in recent onset schizophrenia

Schizophrenia Research

Volumn 146, Issue 1-3, 2013, Pages 238-243

  Takahashi, Shun ^a   Ukai, Satoshi ^a   Kose, Asami ^a   Hashimoto, Tadahiro ^a   Iwatani, Jun ^a   Okumura, Masatoshi ^a   Tsuji, Tomikimi ^a   Shinosaki, Kazuhiro ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Cortical inhibition; GABA; Paired pulse transcranial magnetic stimulation; Recent onset schizophrenia; Working memory

Indexed keywords

BENZODIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT;

ADULT; AGE; ARTICLE; BRIEF ASSESSMENT OF COGNITION IN SCHIZOPHRENIA; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE DURATION; FACILITATION; FEMALE; GABAERGIC INHIBITION; GABAERGIC SYSTEM; HUMAN; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; NERVE CELL INHIBITION; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; SCHIZOPHRENIA; TRANSCRANIAL MAGNETIC STIMULATION; WORKING MEMORY;

ADULT; ANALYSIS OF VARIANCE; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CEREBRAL CORTEX; ELECTROMYOGRAPHY; EVOKED POTENTIALS, MOTOR; FEMALE; HUMANS; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; MOTOR CORTEX; NEURAL INHIBITION; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TRANSCRANIAL MAGNETIC STIMULATION; VERBAL LEARNING; YOUNG ADULT;

EID: 84875939975     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2013.02.033     Document Type: Article

References (60)

1. Addington J., Addington D. Neurocognitive and social functioning in schizophrenia: a 2.5year follow-up study. Schizophr. Res. 2000, 44(1):47-56.
2. Asato M.R., Sweeney J.A., Luna B. Cognitive processes in the development of TOL performance. Neuropsychologia 2006, 44(12):2259-2269.
3. Bartos M., Vida I., Jonas P. Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks. Nat. Rev. Neurosci. 2007, 8(1):45-56.
4. Basar-Eroglu C., Brand A., Hildebrandt H., Kedzior K.K., Mathes B., Schmiedt C. Working memory related gamma oscillations in schizophrenia patients. Int. J. Psychophysiol. 2007, 64(1):39-45.
5. Bilder R.M., Goldman R.S., Robinson D., Reiter G., Bell L., Bates J.A., Pappadopulos E., Willson D.F., Alvir J.M., Woerner M.G., Geisler S., Kane J.M., Lieberman J.A. Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates. Am. J. Psychiatry 2000, 157(4):549-559.
6. Birchwood M., Todd P., Jackson C. Early intervention in psychosis. The critical period hypothesis. Br. J. Psychiatry Suppl. 1998, 172(33):53-59.
7. Cho R.Y., Konecky R.O., Carter C.S. Impairments in frontal cortical gamma synchrony and cognitive control in schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(52):19878-19883.
8. D'Esposito M., Postle B.R., Rypma B. Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies. Exp. Brain Res. 2000, 133(1):3-11.
9. Daskalakis Z.J., Christensen B.K., Chen R., Fitzgerald P.B., Zipursky R.B., Kapur S. Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation. Arch. Gen. Psychiatry 2002, 59(4):347-354.
10. Daskalakis Z.J., Fitzgerald P.B., Christensen B.K. The role of cortical inhibition in the pathophysiology and treatment of schizophrenia. Brain Res. Rev. 2007, 56(2):427-442.
11. Davidson L., McGlashan T.H. The varied outcomes of schizophrenia. Can. J. Psychiatry 1997, 42(1):34-43.
12. Di Lazzaro V., Pilato F., Dileone M., Profice P., Ranieri F., Ricci V., Bria P., Tonali P.A., Ziemann U. Segregating two inhibitory circuits in human motor cortex at the level of GABAA receptor subtypes: a TMS study. Clin. Neurophysiol. 2007, 118(10):2207-2214.
13. Duncan J., Owen A.M. Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends Neurosci. 2000, 23(10):475-483.
14. Eichhammer P., Wiegand R., Kharraz A., Langguth B., Binder H., Hajak G. Cortical excitability in neuroleptic-naive first-episode schizophrenic patients. Schizophr. Res. 2004, 67(2-3):253-259.
15. Eisenberg D.P., Berman K.F. Executive function, neural circuitry, and genetic mechanisms in schizophrenia. Neuropsychopharmacology 2010, 35(1):258-277.
16. Elliott R. Executive functions and their disorders. Br. Med. Bull. 2003, 65:49-59.
17. Elvevåg B., Goldberg T.E. Cognitive impairment in schizophrenia is the core of the disorder. Crit. Rev. Neurobiol. 2000, 14(1):1-21.
18. Fioravanti M., Carlone O., Vitale B., Cinti M.E., Clare L. A meta-analysis of cognitive deficits in adults with a diagnosis of schizophrenia. Neuropsychol. Rev. 2005, 15(2):73-95.
19. Fitzgerald P.B., Brown T.L., Daskalakis Z.J., Kulkarni J. A transcranial magnetic stimulation study of inhibitory deficits in the motor cortex in patients with schizophrenia. Psychiatry Res. 2002, 114(1):11-22.
20. Fitzgerald P.B., Brown T.L., Daskalakis Z.J., Kulkarni J. A transcranial magnetic stimulation study of the effects of olanzapine and risperidone on motor cortical excitability in patients with schizophrenia. Psychopharmacology (Berl) 2002, 162(1):74-81.
21. Galderisi S., Davidson M., Kahn R.S., Mucci A., Boter H., Gheorghe M.D., Rybakowski J.K., Libiger J., Dollfus S., López-Ibor J.J., Peuskens J., Hranov L.G., Fleischhacker W.W. Correlates of cognitive impairment in first episode schizophrenia: the EUFEST study. Schizophr. Res. 2009, 115(2-3):104-114. EUFEST Group.
22. Goldman-Rakic P.S. Cellular basis of working memory. Neuron 1995, 14(3):477-485.
23. Gray J.A., Roth B.L. Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophr. Bull. 2007, 33(5):1100-1119.
24. Green M.F., Kern R.S., Braff D.L., Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"?. Schizophr. Bull. 2000, 26(1):119-136.
25. Green M.F., Kern R.S., Heaton R.K. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr. Res. 2004, 72(1):41-51.
26. Guidotti A., Auta J., Davis J.M., Di-Giorgi-Gerevini V., Dwivedi Y., Grayson D.R., Impagnatiello F., Pandey G., Pesold C., Sharma R., Uzunov D., Costa E. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch. Gen. Psychiatry 2000, 57(11):1061-1069.
27. Guidotti A., Auta J., Davis J.M., Dong E., Grayson D.R., Veldic M., Zhang X., Costa E. GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon. Psychopharmacology (Berl) 2005, 180(2):191-205.
28. Harvey P.D., Green M.F., Keefe R.S., Velligan D.I. Cognitive functioning in schizophrenia: a consensus statement on its role in the definition and evaluation of effective treatments for the illness. J. Clin. Psychiatry 2004, 65(3):361-372.
29. Hashimoto T., Bazmi H.H., Mirnics K., Wu Q., Sampson A.R., Lewis D.A. Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am. J. Psychiatry 2008, 165(4):479-489.
30. Heinrichs R.W., Zakzanis K.K. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998, 12(3):426-445.
31. Howard M.W., Rizzuto D.S., Caplan J.B., Madsen J.R., Lisman J., Aschenbrenner-Scheibe R., Schulze-Bonhage A., Kahana M.J. Gamma oscillations correlate with working memory load in humans. Cereb. Cortex 2003, 13(12):1369-1374.
32. Inagaki A., Inada T. Dose equivalence of psychotropic drugs. Part 18: Dose equivalence of psychotropic drugs: 2006-version. Jpn. J. Clin. Psychopharmacol. 2006, 9(7):1443-1447. (in Japanese).
33. Inagaki A., Inada T. Dose equivalence of psychotropic drugs. Part 21: dose equivalence of novel antipsychotics: blonanserin. Jpn. J. Clin. Psychopharmacol. 2008, 11(5):887-890. (in Japanese).
34. Kaiser J., Bühler M., Lutzenberger W. Magnetoencephalographic gamma-band responses to illusory triangles in humans. Neuroimage 2004, 23(2):551-560.
35. Kaneda Y., Sumiyoshi T., Keefe R., Ishimoto Y., Numata S., Ohmori T. Brief assessment of cognition in schizophrenia: validation of the Japanese version. Psychiatry Clin. Neurosci. 2007, 61(6):602-609.
36. Keefe R.S., Goldberg T.E., Harvey P.D., Gold J.M., Poe M.P., Coughenour L. The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery. Schizophr. Res. 2004, 68(2-3):283-297.
37. Keefe R.S., Poe M., Walker T.M., Harvey P.D. The relationship of the Brief Assessment of Cognition in Schizophrenia (BACS) to functional capacity and real-world functional outcome. J. Clin. Exp. Neuropsychol. 2006, 28(2):260-269.
38. Kujirai T., Caramia M.D., Rothwell J.C., Day B.L., Thompson P.D., Ferbert A., Wroe S., Asselman P., Marsden C.D. Corticocortical inhibition in human motor cortex. J. Physiol. 1993, 471:501-519.
39. Lewis D.A., Moghaddam B. Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch. Neurol. 2006, 63(10):1372-1376.
40. Lewis D.A., Hashimoto T., Volk D.W. Cortical inhibitory neurons and schizophrenia. Nat. Rev. Neurosci. 2005, 6(4):312-324.
41. Liu S.K., Fitzgerald P.B., Daigle M., Chen R., Daskalakis Z.J. The relationship between cortical inhibition, antipsychotic treatment, and the symptoms of schizophrenia. Biol. Psychiatry 2009, 65(6):503-509.
42. McClintock S.M., Freitas C., Oberman L., Lisanby S.H., Pascual-Leone A. Transcranial magnetic stimulation: a neuroscientific probe of cortical function in schizophrenia. Biol. Psychiatry 2011, 70(1):19-27.
43. Meltzer H.Y., Park S., Kessler R. Cognition, schizophrenia, and the atypical antipsychotic drugs. Proc. Natl. Acad. Sci. U. S. A. 1999, 96(24):13591-13593.
44. Minzenberg M.J., Firl A.J., Yoon J.H., Gomes G.C., Reinking C., Carter C.S. Gamma oscillatory power is impaired during cognitive control independent of medication status in first-episode schizophrenia. Neuropsychopharmacology 2010, 35(13):2590-2599.
45. Nakamura H., Kitagawa H., Kawaguchi Y., Tsuji H. Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans. J. Physiol. 1997, 498(3):817-823.
46. Newman S.D., Carpenter P.A., Varma S., Just M.A. Frontal and parietal participation in problem solving in the Tower of London: fMRI and computational modeling of planning and high-level perception. Neuropsychologia 2003, 41(12):1668-1682.
47. Nuechterlein K.H., Barch D.M., Gold J.M., Goldberg T.E., Green M.F., Heaton R.K. Identification of separable cognitive factors in schizophrenia. Schizophr. Res. 2004, 72(1):29-39.
48. Owen A.M., Evans A.C., Petrides M. Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: a positron emission tomography study. Cereb. Cortex 1996, 6(1):31-38.
49. Pascual-Leone A., Manoach D.S., Birnbaum R., Goff D.C. Motor cortical excitability in schizophrenia. Biol. Psychiatry 2002, 52(1):24-31.
50. Stirling J., White C., Lewis S., Hopkins R., Tantam D., Huddy A., Montague L. Neurocognitive function and outcome in first-episode schizophrenia: a 10-year follow-up of an epidemiological cohort. Schizophr. Res. 2003, 65(2-3):75-86.
51. Torrey E.F. Studies of individuals with schizophrenia never treated with antipsychotic medications: a review. Schizophr. Res. 2002, 58(2-3):101-115.
52. Unterrainer J.M., Owen A.M. Planning and problem solving: from neuropsychology to functional neuroimaging. J. Physiol. Paris 2006, 99(4-6):308-317.
53. Volk D.W., Austin M.C., Pierri J.N., Sampson A.R., Lewis D.A. Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch. Gen. Psychiatry 2000, 57(3):237-245.
54. Walter H., Bretschneider V., Grön G., Zurowski B., Wunderlich A.P., Tomczak R., Spitzer M. Evidence for quantitative domain dominance for verbal and spatial working memory in frontal and parietal cortex. Cortex 2003, 39(4-5):897-911.
55. Werheid K., Hoppe C., Thöne A., Müller U., Müngersdorf M., von Cramon D.Y. The Adaptive Digit Ordering Test: clinical application, reliability, and validity of a verbal working memory test. Arch. Clin. Neuropsychol. 2002, 17(6):547-565.
56. Wobrock T., Schneider M., Kadovic D., Schneider-Axmann T., Ecker U.K., Retz W., Rösler M., Falkai P. Reduced cortical inhibition in first-episode schizophrenia. Schizophr. Res. 2008, 105(1-3):252-261.
57. Wobrock T., Hasan A., Malchow B., Wolff-Menzler C., Guse B., Lang N., Schneider-Axmann T., Ecker U.K., Falkai P. Increased cortical inhibition deficits in first-episode schizophrenia with comorbid cannabis abuse. Psychopharmacology (Berl) 2010, 208(3):353-363.
58. Wynn J.K., Light G.A., Breitmeyer B., Nuechterlein K.H., Green M.F. Event-related gamma activity in schizophrenia patients during a visual backward-masking task. Am. J. Psychiatry 2005, 162(12):2330-2336.
59. Ziemann U. TMS and drugs. Clin. Neurophysiol. 2004, 115(8):1717-1729.
60. Zook N.A., Davalos D.B., Delosh E.L., Davis H.P. Working memory, inhibition, and fluid intelligence as predictors of performance on Tower of Hanoi and London tasks. Brain Cogn. 2004, 56(3):286-292.