Changes in the Expression of Transcription Factors Involved in Modulating the Expression of EPO-R in Activated Human CD4-Positive Lymphocytes

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Lisowska, Katarzyna A ^a   Frackowiak, Joanna E ^a   Mikosik, Anna ^a   Witkowski, Jacek M ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIBODY; ERYTHROPOIETIN RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR SP1;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL SURFACE; CONTROLLED STUDY; EPOR GENE; ERYTHROID PRECURSOR CELL; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; T LYMPHOCYTE ACTIVATION;

ADULT; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTE ACTIVATION; MALE; RECEPTORS, ERYTHROPOIETIN; TRANSCRIPTION FACTORS;

EID: 84875935322     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060326     Document Type: Article

References (24)

1. Wickrema A, Krantz SB, Winkelmann JC, Bondurant MC, (1992) Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells. Blood 80: 1940-1949.
2. Anagnostou A, Lee ES, Kessimian N, Levinson R, Steiner M, (1990) Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proc Natl Acad Sci USA 87: 5978-5982.
3. Lisowska KA, Debska-Slizien A, Bryl E, Rutkowski B, Witkowski JM, (2010) Erythropoietin receptor is expressed on human peripheral blood T and B lymphocytes and monocytes and is modulated by recombinant human erythropoietin treatment. Artif Organs 34: 654-662.
4. Lisowska KA, Debska-Slizien A, Jasiulewicz A, Jóźwik A, Rutkowski B, et al. (2011) Flow cytometric analysis of STAT5 phosphorylation and CD95 expression in CD4+ T lymphocytes treated with recombinant human erythropoietin. J Recept Signal Transduct Res 31: 241-246.
5. Mayeux P, Billat C, Jacquot R, (1987) The erythropoietin receptor of rat erythroid progenitor cell: characterization and affinity cross-linkage. J Biol Chem 262: 13985-13990.
6. Bryl E, Mysliwska J, Debska-Slizien A, Rachoń D, Bułło B, et al. (1998) The influence of recombinant human erythropoietin on tumor necrosis factor α and interleukin 10 production by whole blood cell cultures of hemodialysis patients. Artif Organs 22: 177-184.
7. Bryl E, Mysliwska J, Debska-Slizien A, Trzonkowski P, Rachoń D, et al. (1999) Recombinant human erythropoietin stimulates production of interleukin 2 by whole blood cell cultures of hemodialysis patients. Artif Organs 23: 809-816.
8. Trzonkowski P, Myśliwska J, De{ogonek}bska-Ślizień A, Bryl E, Rachoń D, et al. (2002) Long-term therapy with recombinant human erythropoietin decreases percentage of CD152(+) lymphocytes in primary glomerulonephritis haemodialysis patients. Nephrol Dial Transplant 17: 1070-1080.
9. Lisowska KA, Debska-Slizien A, Radzka M, Witkowski JM, Rutkowski B, et al. (2010) Recombinant human erythropoietin treatment of chronic renal failure patients normalizes altered phenotype and proliferation of CD4-positive T lymphocytes. Artif Organs 34: e77-e84.
10. Lisowska KA, Debska-Slizien A, Jasiulewicz A, Daca A, Bryl E, et al. (2012) The influence of recombinant human erythropoietin on apoptosis and cytokine production of CD4+ lymphocytes from hemodialyzed patients. J Clin Immunol DOI 10.1007/s10875-012-9835-4.
11. Chin K, Oda N, Shen K, Noguchi CT, (1995) Regulation of transcription of the human erythropoietin receptor gene by proteins binding to GATA-1 and Sp1 motifs. Nucleic Acids Res 23: 3041-3049.
12. Ho IC, Pai SY, (2007) GATA-3- not just for Th2 cells anymore. Cell Mol Immunol 4: 15-29.
13. Suzuki N, Suwabe N, Ohneda O, Obara N, Imagawa S, et al. (2003) Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels. Blood 102: 3575-3583.
14. Stachura DL, Chou ST, Weiss MJ, (2006) Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1. Blood 107: 87-97.
15. Ho IC, Vorhees P, Marin N, Oakley BK, Tsai SF, et al. (1991) Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor α gene. EMBO J 10: 1187-1192.
16. Wallach I, Zhang J, Hartmann A, van Landeghem FKH, Ivanova A, et al. (2009) Erythropoietin-receptor gene regulation in neuronal cells. Pediatric Res 65: 619-624.
17. Ko LJ, Engel JD, (1993) DNA-binding specificities of the GATA transcription factor family. Mol Cell Biol 13: 4011-4022.
18. Ogilvie M, Yu X, Nicolas-Metral V, Pulido SM, Liu C, et al. (2000) Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts. J Biol Chem 275: 39754-39761.
19. Lacroix I, Lipcey C, Imbert J, Kahn-Perles B, (2002) Sp1 transcriptional activity is up-regulated by phosphatase 2A in dividing T lymphocytes. J Biol Chem 277: 9598-9605.
20. Sela S, Shurtz-Swirski R, Sharon R, Manaster J, Chezar J, et al. (2001) The polymorphonuclear leukocyte - a new target for erythropoietin. Nephron 88: 205-210.
21. Wei-ping Z, Flavell RA, (1997) The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596.
22. Sundrud MS, VanCompernolle SE, Eger KA, Bruno TC, Subramaniam A, et al. (2005) Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells. Blood 106: 3440-3448.
23. Zon LI, Youssoufian H, Mather C, Lodish HF, Orkin SH, (1991) Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc Natl Acad Sci USA 88: 10638-10641.
24. Salisch SV, Klar M, Thurisch B, Bungert J, Dame C, (2011) Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes. J Cell Mol Med 15: 1963-1972.