Computational modeling of nutrient utilization in engineered cartilage

Biotechnology Progress

Volumn 29, Issue 2, 2013, Pages 452-462

  Lin, Tze Hung ^a   Jhang, Han Yun ^b   Chu, Feng Cheng ^b   Chung, C A ^b  

^a Dept of Mechanical Engineering   (China)

^b NATIONAL CENTRAL UNIVERSITY   (Taiwan)

Author keywords

Chondrocytes; Metabolism; Modeling; Simulation; Tissue engineering

Indexed keywords

BOVINE ARTICULAR CHONDROCYTES; CHONDROCYTES; COMPUTATIONAL MODELING; EXPERIMENTAL OBSERVATION; OXYGEN CONCENTRATIONS; RATE OF OXYGEN CONSUMPTION; SIMULATION; SIMULATION DEMONSTRATE;

BODY FLUIDS; CELL CULTURE; GLUCOSE; MATHEMATICAL MODELS; METABOLISM; MODELS; NUTRIENTS; OXYGEN; TISSUE ENGINEERING;

SCAFFOLDS (BIOLOGY);

GLUCOSE; OXYGEN; TISSUE SCAFFOLD;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CARTILAGE; CARTILAGE CELL; CATTLE; CHEMISTRY; CULTURE MEDIUM; CYTOLOGY; METABOLISM; THEORETICAL MODEL; TISSUE ENGINEERING;

ANIMALS; CARTILAGE; CATTLE; CHONDROCYTES; CULTURE MEDIA; GLUCOSE; MODELS, BIOLOGICAL; MODELS, THEORETICAL; OXYGEN; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

BOVINAE;

EID: 84875935062     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1687     Document Type: Article

References (39)

1. Langer R, Vacanti JP. Tissue engineering. Science. 1993;260:920-926.
2. Griffith LG, Naughton G. Tissue engineering: Current challenges and expanding opportunities. Science. 2002;295:1009-1014.
3. Ishaug-Riley SL, Okun LE, Prado G, Applegate MA, Ratcliffec A. Human articular chondrocyte adhesion and proliferation on synthetic biodegradable polymer films. Biomaterials. 1999;20: 2245-2256.
4. Zhang WJ, Liu W, Cao Y. Tissue engineering of blood vessel. J Cell Mol Med. 2007;11:945-957.
5. Jain RA. The manufacturing techniques of various drug loaded biodegradable poly (lactide-co-glycolide) (PLGA) devices. Biomaterials. 2000;21:2475-2490.
6. Boyce ST. Fabrication, quality assurance, and assessment of cultured skin substitutes for treatment of skin wounds. Biochem Eng J. 2004;20:107-112.
7. Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartil. 2001;10:432-463.
8. Kremer M, Lanf E, Berger AC. Evaluation of dermal-epidermal skin. equivalents ('composite-skin') of human keratinocytes in a collagen-glycosaminoglycan matrix (IntegraTM Artificial Skin). Br J Plast Surg. 2000;53:459-465.
9. Lysaght MJ, Hazlehurst AL. Tissue engineering: the end of beginning. Tissue Eng. 2004;10:309-317.
10. Freed LE, Marquis JC, Vunjak-Novakovic G, Emmanual J, Langer R. Composition of cell-polymer cartilage implants. Biotechnol Bioeng. 1994;43:605-614.
11. Freed LE, Vunjak-Novakovic G, Marquis JC, Langer R. Kinetics of chondrocyte growth in cell-polymer implants. Biotechnol Bioeng. 1994;43:597-604.
12. Malda J, Rouwkema J, Martens DE, Le Comte EP, Kooy FK, Tramper J, van Blitterswijk CA, Riesle J. Oxygen Gradients in Tissue-Engineered PEGT/PBT Cartilaginous Constructs: Measurement and Modeling. Biotechnol Bioeng. 2004;86:9-18.
13. Obradovic B, Carrier RL, Vunjak-Novakovic G, Freed LE. Gas exchange is essential for bioreactor incubation of tissue engineered cartilage. Biotechnol Bioeng. 1999;63:197-205.
14. Lee RB, Urban JPG. Evidence for a negative Pasteur effect in articular cartilage. Biochem J. 1997;321:95-102.
15. Obradovic B, Freed LE, Langer R, Vunjak-Novakovic G. Bioreactor studies of natural and engineered cartilage metabolism. Proceedings of the Topical Conference on Biomaterials, Carriers for Drug Delivery, and Scaffolds for Tissue Engineering. 1997:335-337.
16. Ishihara H, Urban JPG. Effects of low oxygen concentrations and metabolic inhibitors on proteoglycan and protein synthesis rates in the intervertebral disc. J Orthop Res. 1999;17:829-835.
17. Marcus RE. The effect of low oxygen concentration on growth, glycolysis, and sulfate incorporation by articular chondrocytes in monolayer culture. Arthritis Rheum. 1973;16:646-656.
18. Obradovic B, Meldon JH, Freed LE, Vunjak-Novakovic G. Glycosaminoglycan deposition in engineered cartilage: Experiments and mathematical model. AIChE J. 2000;46:1860-1871.
19. Chung CA, Ho SY. Analysis of collagen and glucose modulated cell growth within tissue engineered scaffolds. Ann Biomed Eng. 2010;38:1655-1663.
20. Malda J, Woodfield TBF, van der Vloodt F, Wilson C, Martens DE, Tramper J, van Blitterswijk CA, Riesle J. The effect of PEGT/PBT scaffold architecture on the composition of tissue engineered cartilage. Biomaterials. 2005;26:63-72.
21. Sengers BG, Heywood HK, Lee DA, Oomens CWJ, Bader DL. Nutrient utilization by bovine articular chondrocytes: A combined experimental and theoretical approach. J Biomech Eng. 2005;127:758-766.
22. Schwartz ER, Kirkpatrick PR, Thompson RC. The effect of environmental pH on glycosaminoglycan metabolism by normal human chondrocytes. J Lab Clin Med. 1976;87:198-205.
23. Wu MH, Urban JPG., Cui ZF, Cui Z, Xu X. Effect of extracellular pH on matrix synthesis by chondrocytes in 3D agarose gel. Biotechnol Prog. 2007;23:430-434.
24. Zhou S, Cui Z, Urban JPG. Nutrient gradients in engineered cartilage: metabolic kinetics measurement and mass transfer modeling. Biotechnol Bioeng. 2008;101:408-421.
25. Soukane DM, Shirazi-Adl A, Urban, JPG. Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc. J Biomech. 2007;40:2645-2654.
26. Bibby SRS, Jones DA, Ripley RM, Urban JPG. Metabolism of the intervertebral disc: Effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells. Spine. 2005;30:487-496.
27. Galban CJ, Locke BR. Analysis of cell growth kinetic and substrate diffusion in a polymer scaffold. Biotechnol Bioeng. 1999;65:121-132.
28. Galban CJ, Locke BR. Effects of spatial variation of cells and nutrient and product concentrations coupled with product inhibition on cell growth in a polymer scaffold. Biotechnol Bioeng. 1999;64:633-643.
29. Burstein D, Gray ML, Hartman AL, Gipe R, Foy BD. Diffusion of small solutes in cartilage as measured by nuclear magnetic resonance spectroscopy and imaging. J Orthop Res. 1993;11:465-478.
30. Gu W, Yao H, Vega A, Flagler D. Diffusivity of Ions in agarose gels and intervertebral disc: Effect of porosity. Ann Biomed Eng. 2004;32:1710-1717.
31. Nimer E, Schneiderman R, Maroudas A. Diffusion and partition of solutes in cartilage under static load. Biophys Chem. 2003;106:125-146.
32. Bailey JE, Ollis DF. Biochemical Engineering Fundamentals, 2nd ed. New York: McGraw-Hill; 1986.
33. Haselgrove JC, Shapiro IM, Silverton SF. Computer modeling of the oxygen supply and demand of cells of the avian growth cartilage. Am J Physiol: Cell Physiol. 1993;256:C497-C506.
34. Windhaber RAJ, Wilkins RJ. Functional characterization of glucose transport in bovine articular chondrocytes. Pflügers Arch. Eur J Physiol. 2003;446:572-577.
35. Venkatasubramanian R, Henson MA, Forbes NS. Incorporating energy metabolism into a growth model of multicellular tumor spheroids. J Theor Biol. 2006;42:449-453.
36. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. Molecular Biology of the Cell, 3rd ed. New York: Garland Publishing; 1994.
37. Lee RB, Urban JPG. Functional replacement of oxygen by other oxidants in articular cartilage. Arthritis Rheum. 2002;46:3190-3200.
38. Torzilli PA, Askari E, Jenkins JT. Water content and solute diffusion properties in articular cartilage. In: Mow VC, Ratcliffe A, Woo SL, editors. Biomechanics of Diarthrodial Joints. New York: Springer-Verlag; 1990:363-390.
39. Holm S, Maroudas A, Urban JPG, Selstam G., Nachemson A. Nutrition of the intervertebral disc: solute transport and metabolism. Connect Tissue Res. 1981;8:101-119.