Metformin: Myths, misunderstandings and lessons from history

Australian Prescriber

Volumn 36, Issue 2, 2013, Pages 38-39

  Shenfield, Gillian ^a  

^a Northern Sydney Central Coast Health   (Australia)

Author keywords

Biguanides; Lactic acidosis; Type 2 diabetes

Indexed keywords

CHLORPROPAMIDE; GALEGINE; INSULIN; METFORMIN; PHENFORMIN; SULFONYLUREA DERIVATIVE;

DRUG EXCRETION; DRUG FATALITY; DRUG MECHANISM; DRUG METABOLISM; DRUG SAFETY; EDITORIAL; GALEGA; GALEGA OFFICINALIS; GASTROINTESTINAL SYMPTOM; GLYCEMIC CONTROL; HEART INFARCTION; HUMAN; HYPOGLYCEMIA; LACTIC ACIDOSIS; META ANALYSIS (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OVARY POLYCYSTIC DISEASE; PREGNANCY DIABETES MELLITUS; RISK REDUCTION; SIDE EFFECT; WEIGHT GAIN; WEIGHT REDUCTION;

EID: 84875925034     PISSN: 03128008     EISSN: None     Source Type: Journal    
DOI: 10.18773/austprescr.2013.017     Document Type: Editorial

References (9)

1. Stades AM, Heikens JT, Erkelens DW, Holleman F, Hoekstra JB. Metformin and lactic acidosis: cause or coincidence? A review of case reports. J Intern Med 2004;255:179-87.
2. Clarke BF, Duncan LJ. Comparison of chlorpropamide and metformin treatment on weight and blood-glucose response of uncontrolled obese diabetics. Lancet 1968;1:123-6.
3. Clarke BF, Campbell IW. Comparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics uncontrolled by diet. Br Med J 1977;2:1576-8.
4. Bailey CJ, Turner RC. Metformin. N Engl J Med 1996;334:574-9.
5. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-53.
6. Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364-79.
7. Hemmingsen B, Christensen LL, Wetterslev J, Vaag A, Gluud C, Lund SS, et al. Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses. BMJ 2012;344:e1771.
8. Roumie CL, Hung AM, Greevy RA, Grijalva CG, Liu X, Murff HJ, et al. Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: a cohort study. Ann Intern Med 2012;157:601-10.
9. Gale EA. Collateral damage: the conundrum of drug safety. Diabetologia 2009;52:1975-82.