Single non-ionic surfactant based self-nanoemulsifying drug delivery systems: Formulation, characterization, cytotoxicity and permeability enhancement study

Drug Development and Industrial Pharmacy

Volumn 39, Issue 5, 2013, Pages 696-703

  Bandivadekar, Mithun ^a   Pancholi, Shyamsundar ^b   Kaul Ghanekar, Ruchika ^c   Choudhari, Amit ^c   Koppikar, Soumya ^c  

^a AISSMS COLLEGE OF PHARMACY   (India)

^b Gujarat Technological University   (India)

^c BHARATI VIDYAPEETH UNIVERSITY   (India)

Author keywords

Caco 2 cell line; Cremophor EL; Cremophor RH 40; Cytotoxicity; Dissolution efficiency; SNEDDS; Tween 20

Indexed keywords

ATORVASTATIN; CREMOPHOR; LABRASOL; NONIONIC SURFACTANT; OCTANOIN; POLYSORBATE 20; POLYSORBATE 60; POLYSORBATE 80;

ARTICLE; CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; HUMAN; HUMAN CELL; NANOEMULSION; REFRACTION INDEX; SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM; ZETA POTENTIAL;

ANTICHOLESTEREMIC AGENTS; CACO-2 CELLS; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; GLYCEROL; HEPTANOIC ACIDS; HUMANS; NANOPARTICLES; PARTICLE SIZE; PERMEABILITY; PYRROLES; SOLUBILITY; SURFACE-ACTIVE AGENTS;

EID: 84875911020     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.687745     Document Type: Article

References (16)

1. Pouton CW. (2000). Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and 'selfmicroemulsifying' drug delivery systems. Eur J Pharm Sci, 11 Suppl 2:S93-S98.
2. Rane SS, Anderson BD. (2008). What determines drug solubility in lipid vehicles: Is it predictable? Adv Drug Deliv Rev, 60:638-656.
3. Wasan EK, Bartlett K, Gershkovich P, Sivak O, Banno B, Wong Z et al. (2009). Development and characterization of oral lipid-based amphotericin B formulations with enhanced drug solubility, stability and antifungal activity in rats infected with Aspergillus fumigatus or Candida albicans. Int J Pharm, 372:76-84.
4. Date AA, Nagarsenker MS. (2007). Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int J Pharm, 329:166-172.
5. Porter CJ, Pouton CW, Cuine JF, Charman WN. (2008). Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev, 60:673-691.
6. Gursoy RN, Benita S. (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother, 58:173-182.
7. Warisnoicharoen W, Lansley AB, Lawrence MJ. (2000). Nonionic oil-in-water microemulsions: The effect of oil type on phase behaviour. Int J Pharm, 198:7-27.
8. Craig DQM, Barker SA, Banning, Booth SW. (1995). An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int J Pharm, 114:103-110.
9. Wakerly G, Pouton CW, Meakin BJ. (1987). Evaluation of the selfemulsifying performance of a non-ionic surfactant vegetable oil mixture. J Pharm Pharmacol, 39:6.
10. Eastoe J, Hetherington KJ, Sharpe D, Dong J. (1996). Mixing of alkanes with surfactant monolayer's in microemulsions. Langmuir, 12:3876-3880.
11. Warisnoicharoen W, Lansley AB, Lawrence MJ. (2000). Light scattering investigations on dilute nonionic oil-in-water microemulsions. AAPS Pharm Sci, 2:E12.
12. Malcolmson C, Lawrence MJ. (1995). Three component nonionic oil-in-water microemulsion using polyoxyethylene ether surfactants, Colloids and surface B. Biointerface, 4:97-109.
13. Shah NH, Carvajal MT, Patel CI, Infeld MH, Malick AW. (1994). Selfemulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm, 106:15-23.
14. Jing C, Bo Y, Yu Z, Weiwe Z, Houli IL, Hongxiang L, Guangxi Z. (2008). Enhancement of oral absorption of curcumin by self-micro emulsifying drug delivery systems. 12:009.
15. Itoh K, Tozuka Y, Oguchi T, Yamamoto K. (2002). Improvement of physicochemical properties of N-4472 part I formulation design by using self-microemulsifying system. Int J Pharm, 238:153-160.
16. Wei W, Yang W, Li Q. (2006). Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system. Eur J Pharma Biopharm, 63:288-294.