The role of p16 expression as a predictive marker in HPVpositive oral SCCHN - A retrospective single-center study

Anticancer Research

Volumn 33, Issue 3, 2013, Pages 913-916

  Geißler, Christin ^a   Tahtali, Aykut ^a   Diensthuber, Marc ^a   Gassner, Davina ^a   Stover, Timo ^a   Wagenblast, Jens ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

HPV infection; P16 expression; SCCHN

Indexed keywords

VIRUS DNA;

ARTICLE; CLINICAL ARTICLE; DIAGNOSTIC VALUE; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HIGH RISK PATIENT; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 6; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUTH SQUAMOUS CELL CARCINOMA; ONCOGENE; P16 GENE; PAPILLOMAVIRUS INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; VIRUS DETECTION;

BIOLOGICAL MARKERS; CARCINOMA, SQUAMOUS CELL; DNA, VIRAL; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MOUTH NEOPLASMS; NEOPLASM PROTEINS; PAPILLOMAVIRIDAE; RETROSPECTIVE STUDIES;

EID: 84875896652     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Matzinger O, Zouhair A, Mirimanoff RO and Ozsahin M: Radiochemotherapy in locally advanced squamous cell carcinomas of the head and neck. Clin Oncol (R Coll Radiol). 21: 525-531, 2009.
2. Leemans CR, Braakhuis BJ and Brakenhoff RH: The molecular biology of head and neck Cancer. Nat Rev Cancer 11: 9-22, 2011.
3. Kreimer AR, Clifford GM, Boyle P and Franceschi S: Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systematic review. Cancer Epidemiol Biomarkers Prev 14: 467-475, 2005.
4. Chung CH and Gillison ML: Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clin Cancer Res 15: 6758-6762, 2009.
5. Gillespie MB, Rubinchik S, Hoel B and Sutkowski N: Human papillomavirus and oropharyngeal cancer: What you need to know in 2009. Curr Treat Options Oncol 10: 296-307, 2009.
6. Marur S, D'Souza G, Westra WH and Forastiere AA: HPVassociated head and neck cancer: A virus-related cancer epidemic. Lancet Oncol 11: 781-789, 2010.
7. Williams GH and Stoeber K: The cell cycle and cancer. J Pathol 226: 352-364, 2012.
8. Butt WT, Butt MU, Tariq S, Ahmad R, Ali TS, Bukhari MH, Naeem S and Munir M: Molecular Pathogenesis, Epidemiology, Risk Factors & Prognosis of Head and Neck Cancers in Relation to Human Papilloma Virus Infection. AKEMU 13: 169-178, 2007.
9. Glazer CA, Chang SS, Ha PK and Califano JA: Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice. Oral Oncol 45: 440-446, 2009.
10. Park HW, Song SY, Lee TJ, Jeong D and Lee TY: Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas. Oncol Rep 18: 267-272, 2007.
11. Lehnerdt G, Hoffmann TK, Mattheis S, Brandau S, Zeidler R and Lang S: Diagnostic and prognostic biomarkers in head and neck squamous cell carcinoma. HNO 58: 713-723, 2010.
12. Hoffmann M, Ihloff AS, Gorogh T, Weise JB, Fazel A, Krams M, Rittgen W, Schwarz E and Kahn T: p16(INK4a) overexpression predicts translational active human papillomavirus infection in tonsillar cancer. Int J Cancer 127: 1595-1602, 2010.
13. Kumar B, Cordell KG, Lee JS, Worden FP, Prince ME, Tran HH, Wolf GT, Urba SG, Chepeha DB, Teknos TN, Eisbruch A, Tsien CI, Taylor JM, D'Silva NJ, Yang K, Kurnit DM, Bauer JA, Bradford CR and Carey TE: EGFR, p16, HPV titer, BCL-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol 26: 3128-3137, 2008.
14. Smeets SJ, Hesselink AT, Speel EJ, Haesevoets A, Snijders PJ, Pawlita M, Meijer CJ, Braakhuis BJ, Leemans CR and Brakenhoff RH: A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimes. Int J Cancer 121: 2465-2472, 2007.
15. Heath S, Willis V, Allan K, Purdie K, Harwood C, Shields P, Simcock R, Williams T and Gilbert DC: Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice. Clin Oncol (R Coll Radiol) 24: e18-23, 2012.
16. Manos MM, Ting Y, Wright DK, Lewis AJ, Broker TR and Wolinsky SM: Use of polymerase chain reaction amplification for the detection of genital human papillomaviruses. Cancer Cells 7: 209-214, 1989.
17. Rocha-Zavaleta L, Ambrosio JP, Mora-Garcia Mde L, Cruz- Talonia F, Hernandez-Montes J, Weiss-Steider B, Ortiz- Navarrete V and Monroy-Garcia A: Detection of antibodies against a human papillomavirus (HPV) type peptide that differentiate high-risk from low-risk HPV-associated low-grade squamous intraepithelial lesions. J Gen Virol 85: 2643-2650, 2004.
18. Saiki RK, Bugawan TL, Horn GT, Mullis KB and Erlich HA: Analysis of enzymatically amplified beta-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probes. Nature 324: 163-166, 1986.
19. Klozar J, Tachezy R, Rotnaglova E, Koslabova E, Salakova M and Hamsikova E: Human papillomavirus in head and neck tumors: Epidemiological, molecular and clinical aspects. Wien Med Wochenschr 160: 305-309, 2010.
20. McLaughlin-Drubin ME, Crum CP and Munger K: Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming. Proc Natl Acad Sci USA 108: 2130-2135, 2011.
21. Longworth MS and Laimins LA: Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev 68: 362-372, 2004.
22. Hoffmann M, Tribius S, Quabius ES, Henry H, Pfannenschmidt S, Burkhardt C, Gorogh T, Halec G, Hoffmann AS, Kahn T, Rocken C, Haag J, Waterboer T and Schmitt M: HPV DNA, E6(*)I-mRNA expression and p16(INK4A) immunohistochemistry in head and neck cancer - How valid is p16(INK4A) as surrogate marker? Cancer Lett 323: 88-96, 2012.