Kinetics of IFN-gamma and TNF-alpha gene expression and their relationship with disease progression after infection with Mycobacterium Tuberculosis in guinea pigs

Yonsei Medical Journal

Volumn 54, Issue 3, 2013, Pages 707-714

  Roh, In Soon ^a,b   Cho, Sungae ^a,c   Eum, Seok Yong ^d   Cho, Sang Nae ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Animal Plant and Fisheries Quarantine and Inspection Agency   (South Korea)

^c Sogang University   (South Korea)

^d International Tuberculosis Research Center   (South Korea)

Author keywords

Guinea pigs; IFN ; Mycobacterium tuberculosis; Pathogenesis; TNF

Indexed keywords

CYTOKINE; GAMMA INTERFERON; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHITIS; BRONCHOPNEUMONIA; CONTROLLED STUDY; DISEASE COURSE; ENZYME KINETICS; FEMALE; GENE EXPRESSION; GRANULOMA; GRANULOMATOUS INFLAMMATION; GROWTH CURVE; GUINEA PIG; HISTOPATHOLOGY; MICROSCOPY; MYCOBACTERIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUBERCULOSIS; WEIGHT CHANGE;

GUINEA PIGS; IFN-Γ; MYCOBACTERIUM TUBERCULOSIS; PATHOGENESIS; TNF-Α;

ANIMALS; BODY WEIGHT; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GUINEA PIGS; INTERFERON-GAMMA; KINETICS; LIVER; LUNG; LYMPH NODES; MYCOBACTERIUM TUBERCULOSIS; SPLEEN; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84875887686     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2013.54.3.707     Document Type: Article

References (50)

1. Tuberculosis control and research strategies for the 1990s: memorandum from a WHO meeting. Bull World Health Organ 1992;70: 17-21.
2. Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Ravi-glione MC, et al. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med 2003;163:1009-1021.
3. WHO. Global tuberculosis report 2011. http://www.who.int/tb/ publications/global_report/2011/en/index.html.
4. Roche PW, Triccas JA, Winter N. BCG vaccination against tuberculosis: past disappointments and future hopes. Trends Microbiol 1995;3:397-401.
5. Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Karonga Prevention Trial Group. Lancet 1996;348:17-24.
6. McShane H. Tuberculosis vaccines: beyond bacille Calmette-Guerin. Philos Trans R Soc Lond B Biol Sci 2011;366:2782-2789.
7. Rowland R, McShane H. Tuberculosis vaccines in clinical trials. Expert Rev Vaccines 2011;10:645-658.
8. Shah NS, Wright A, Bai GH, Barrera L, Boulahbal F, Martín-Cas-abona N, et al. Worldwide emergence of extensively drug-resistant tuberculosis. Emerg Infect Dis 2007;13:380-387.
9. Chan ED, Iseman MD. Multidrug-resistant and extensively drug-resistant tuberculosis: a review. Curr Opin Infect Dis 2008;21:587-595.
10. Barry CE 3rd, Blanchard JS. The chemical biology of new drugs in the development for tuberculosis. Curr Opin Chem Biol 2010; 14:456-466.
11. Shin SS, Keshavjee S, Gelmanova IY, Atwood S, Franke MF, Mishustin SP, et al. Development of extensively drug-resistant tuberculosis during multidrug-resistant tuberculosis treatment. Am J Respir Crit Care Med 2010;182:426-432.
12. Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, et al. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 2006;368:1575-1580.
13. Ma Z, Lienhardt C, McIlleron H, Nunn AJ, Wang X. Global tuberculosis drug development pipeline: the need and the reality. Lancet 2010;375:2100-2109.
14. Dannenberg AM Jr. Perspectives on clinical and preclinical testing of new tuberculosis vaccines. Clin Microbiol Rev 2010;23:781-794.
15. Cole ST, Riccardi G. New tuberculosis drugs on the horizon. Curr Opin Microbiol 2011;14:570-576.
16. Okada M, Kita Y. Tuberculosis vaccine development: the development of novel (preclinical) DNA vaccine. Hum Vaccin 2010;6: 297-308.
17. Checkley AM, McShane H. Tuberculosis vaccines: progress and challenges. Trends Pharmacol Sci 2011;32:601-606.
18. Smith DW, Balasubramanian V, Wiegeshaus E. A guinea pig model of experimental airborne tuberculosis for evaluation of the response to chemotherapy: the effect on bacilli in the initial phase of treatment. Tubercle 1991;72:223-231.
19. Dannenberg AM Jr, Collins FM. Progressive pulmonary tuberculosis is not due to increasing numbers of viable bacilli in rabbits, mice and guinea pigs, but is due to a continuous host response to mycobacterial products. Tuberculosis (Edinb) 2001;81:229-242.
20. McMurray DN, Allen SS, Jeevan A, Lasco T, Cho H, Skwor T, et al. Vaccine-induced cytokine responses in a guinea pig model of pulmonary tuberculosis. Tuberculosis (Edinb) 2005;85:295-301.
21. Sugawara I, Udagawa T, Aoki T, Mizuno S. Establishment of a guinea pig model of latent tuberculosis with GFP-introduced Mycobacterium tuberculosis. Tohoku J Exp Med 2009;219:257-262.
22. Young D. Animal models of tuberculosis. Eur J Immunol 2009; 39:2011-4.
23. Ahmad Z, Fraig MM, Pinn ML, Tyagi S, Nuermberger EL, Gros-set JH, et al. Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models. J Antimicrob Chemother 2011;66:1560-1566.
24. Grover A, Troudt J, Arnett K, Izzo L, Lucas M, Strain K, et al. Assessment of vaccine testing at three laboratories using the guinea pig model of tuberculosis. Tuberculosis (Edinb) 2012;92:105-111.
25. Salgame P. Host innate and Th1 responses and the bacterial factors that control Mycobacterium tuberculosis infection. Curr Opin Immunol 2005;17:374-380.
26. Cooper AM. T cells in mycobacterial infection and disease. Curr Opin Immunol 2009;21:378-384.
27. Jeon BY, Eoh H, Ha SJ, Bang H, Kim SC, Sung YC, et al. Co-immunization of plasmid DNA encoding IL-12 and IL-18 with Bacillus Calmette-Guérin vaccine against progressive tuberculosis. Yonsei Med J 2011;52:1008-1015.
28. North RJ, Jung YJ. Immunity to tuberculosis. Annu Rev Immunol 2004;22:599-623.
29. Gupta A, Kaul A, Tsolaki AG, Kishore U, Bhakta S. Mycobacteri-um tuberculosis: immune evasion, latency and reactivation. Im-munobiology 2012;217:363-374.
30. Brighenti S, Andersson J. Local immune responses in human tuberculosis: learning from the site of infection. J Infect Dis 2012; 205 Suppl 2:S316-324.
31. Orme IM, Cooper AM. Cytokine/chemokine cascades in immunity to tuberculosis. Immunol Today 1999;20:307-312.
32. Rahman S, Gudetta B, Fink J, Granath A, Ashenaf S, Aseffa A, et al. Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions. Am J Pathol 2009; 174:2211-2224.
33. Kawahara M, Nakasone T, Honda M. Dynamics of gamma inter-feron, interleukin-12 (IL-12), IL-10, and transforming growth factor beta mRNA expression in primary Mycobacterium bovis BCG infection in guinea pigs measured by a real-time fuorogenic reverse transcription-PCR assay. Infect Immun 2002;70:6614-6620.
34. Cho H, Lasco TM, Allen SS, Yoshimura T, McMurray DN. Recom-binant guinea pig tumor necrosis factor alpha stimulates the expression of interleukin-12 and the inhibition of Mycobacterium tuberculosis growth in macrophages. Infect Immun 2005;73:1367-1376.
35. McMurray DN. Hematogenous reseeding of the lung in low-dose, aerosol-infected guinea pigs: unique features of the host-pathogen interface in secondary tubercles. Tuberculosis (Edinb) 2003;83: 131-134.
36. Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russell DG, Orme IM. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 1993;178:2243-2247.
37. Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role for interferon gamma in resistance to Myco-bacterium tuberculosis infection. J Exp Med 1993;178:2249-2254.
38. Ly LH, Russell MI, McMurray DN. Cytokine profles in primary and secondary pulmonary granulomas of Guinea pigs with tuberculosis. Am J Respir Cell Mol Biol 2008;38:455-462.
39. Ly LH, Russell MI, McMurray DN. Microdissection of the cyto-kine milieu of pulmonary granulomas from tuberculous guinea pigs. Cell Microbiol 2007;9:1127-1136.
40. Chackerian AA, Alt JM, Perera TV, Dascher CC, Behar SM. Dissemination of Mycobacterium tuberculosis is infuenced by host factors and precedes the initiation of T-cell immunity. Infect Im-mun 2002;70:4501-4509.
41. Fenhalls G, Stevens L, Bezuidenhout J, Amphlett GE, Duncan K, Bardin P, et al. Distribution of IFN-gamma, IL-4 and TNF-alpha protein and CD8 T cells producing IL-12p40 mRNA in human lung tuberculous granulomas. Immunology 2002;105:325-335.
42. Fuller CL, Flynn JL, Reinhart TA. In situ study of abundant expression of proinfammatory chemokines and cytokines in pulmonary granulomas that develop in cynomolgus macaques experimentally infected with Mycobacterium tuberculosis. Infect Immun 2003;71:7023-7034.
43. Aung H, Toossi Z, McKenna SM, Gogate P, Sierra J, Sada E, et al. Expression of transforming growth factor-beta but not tumor necrosis factor-alpha, interferon-gamma, and interleukin-4 in granu-lomatous lung lesions in tuberculosis. Tuber Lung Dis 2000;80: 61-67.
44. Dai G, McMurray DN. Effects of modulating TGF-beta 1 on immune responses to mycobacterial infection in guinea pigs. Tuber Lung Dis 1999;79:207-214.
45. Fenhalls G, Wong A, Bezuidenhout J, van Helden P, Bardin P, Lukey PT. In situ production of gamma interferon, interleukin-4, and tumor necrosis factor alpha mRNA in human lung tuberculous granulomas. Infect Immun 2000;68:2827-2836.
46. Allen SS, Cassone L, Lasco TM, McMurray DN. Effect of neutralizing transforming growth factor beta1 on the immune response against Mycobacterium tuberculosis in guinea pigs. Infect Immun 2004;72:1358-1363.
47. Grover A, Taylor J, Troudt J, Keyser A, Arnett K, Izzo L, et al. Kinetics of the immune response profle in guinea pigs after vaccination with Mycobacterium bovis BCG and infection with Mycobac-terium tuberculosis. Infect Immun 2009;77:4837-4846.
48. Jeevan A, Yoshimura T, Ly LH, Dirisala VR, McMurray DN. Cloning of guinea pig IL-4: reduced IL-4 mRNA after vaccination or Mycobacterium tuberculosis infection. Tuberculosis (Edinb) 2011;91:47-56.
49. Dirisala VR, Jeevan A, Bix G, Yoshimura T, McMurray DN. Molecular cloning and expression of the IL-10 gene from guinea pigs. Gene 2012;498:120-127.
50. Iwakura Y, Nakae S, Saijo S, Ishigame H. The roles of IL-17A in infammatory immune responses and host defense against pathogens. Immunol Rev 2008;226:57-79.