Biochemical evaluation of anti-diabetic phytomolecule through bioactivity guided solvent fractionation and subfractionation from hydro-methanolic (2:3) extract of alligator pear fruit in streptozotocin induced diabetic rats

Journal of Applied Pharmaceutical Science

Volumn 2, Issue 1, 2012, Pages 61-69

  Thenmozhi, A ^a   Shanmugasundaram, C ^b   Mahadeva Rao, U S ^c  

^a SRM Arts and Science College Chennai   (India)

^b VIVEKANANDA COLLEGE   (India)

^c UNIVERSITI SULTAN ZAINAL ABIDIN   (Malaysia)

Author keywords

Hypoglycemic; Insulin; Persea Americana Mill; Ph ytomolecule; Transaminase

Indexed keywords

EID: 84875884050     PISSN: None     EISSN: 22313354     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Aiston S, Andersen B, Agius L. Glucose 6- phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase. Diabetologia 2003; 52:1333-9.
2. Anon Z. Determination of LDH by UV-kinetic method. In: Klin Z, Chem UK, eds. Biochemistry.1970. 8:658.
3. Bastaki S, Diabetes mellitus and its treatment, Int J Diabetes Metabol. (2005) 13, 111-34.
4. Bergh, B. Nutritious Value of Avocado. California Avocado Society Book, CA (1992) 123-35.
5. Brugi W et al. One step sandwich enzyme immunoassay for insulin using monoclonal antibodies ClinBiochem1998; 21: 311-4.
6. Canep ET, Llambias EB, Grinstein M, studies on regulatory mechanisms of heme biosynthesis in hepatocytes from normal and experimental-diabetic rats. Role of insulin, Biochem Cell Biol 1990;68:91-8.
7. Chandalia HB, Sadikot S, Bhargava DK, Krisnaswami PR. Estimation of glycosylated hemoglobin by a simple chemical method. J Assoc Phys Ind 1980; 29: 285-6
8. Chatterjea MN and Rana Shinde, Diabetes Mellitus In: Jaypee Bros Medical Publishers Ltd. New Delhi, Text book of Medical Biochemistry 5th Edition. 2002; 315-20.
9. Chou AC, Wilson JE. Carbohydrate metabolism. In: Wood WA, ed. Methods in Enzymology. New York:Academic Press, 1975: 20-1.
10. De D, Debasis, Ghosh, Debidas. Antidiabetic and antioxidative effects of hydromethanolic extract of sepals of Salmalia malabarica in streptozotocin induced diabetic rats. J Appl Biomed 2010; 8: 19-27.
11. Ghosh MN. Fundamentals of Experimental Pharmacology. 4th edn. Calcutta: Scientific Book Agency, 1984.
12. Ghosh S, Suryawanshi SA. Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Ind J Experiment Biol 2001; 39: 748-59.
13. Gray, D S The clinical uses of dietary fiber. Am. Family Phys. 1995; 51: 419-26.
14. Henry. RJ, Chiomari N, Golub OJ Revised spectrophotometric methods for the determination of glutamate oxaloacetic transaminase, glutamic pyruvate transaminase and lactic acid dehydrogenase. Am J Clin Path 1960; 34: 381-98.
15. Kasetti RB, Rajasekhar. Hypoglycemic and antihyperlipidemic activities of methanol: water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocininduced diabetic rats. Food Chem Toxicol 2010; 48: 1078-84.
16. Kemp A. Van Hejnigen AJMK. A colorimetric micro-method for the determination of glycogen in tissues.Biochem 1954; 56: 646-8.
17. Kreisberg RA, Diabetic dyslipidemia, Am J Cardiole. (1998), 82, 67U-73U.
18. Kritchevsky, D. & Bonfield, C. Dietary Fiber in Health & Disease Eagan Press, St. Paul, MN. 1995;195-9.
19. Kruszynska YT et al. Regulation of skeletal muscle hexokinase II by insulin in nondiabetic and NIDDM subjects. Diabetologia 1998; 47: 1107-13.
20. Langdon RG. Glucose-6-phosphate dehydrogenase from erythrocytes. In: Wood WA, ed. Methods in Enzymology. New York: Academic Press, 1966:126-31.
21. Leduc C, Coonishish J, Haddad P, Cuerrier A. Plants used by the Cree Nation of Eeyou Istchee (Quebec, Canada) for the treatment of diabetes: anovel approach in quantitative ethnobotany. J Ethnopharmacol 2006; 105: 55-63.
22. Loomis TA. Essential of Toxicology. Phil Le 1968; 6: 67-78.
23. Ragavan B, Krishnakumari S. Antidiabetic effect of T. arjuna bark extract in alloxan induced diabetic rats. Ind J Clin Biochem 2006; 21: 123-8.
24. Rajasekaran S, Subramaian S. Hypoglycemic effect of Aloe vera on streptozotocin induced diabetes in experimental rats. J Med Food 2004; 7: 61-6.
25. Rakieten N, Rakieten ML, Nadkarni MV, Studies on the diabetogenic action of streptozotocin (NSC-37917), Cancer Chemother Rep.1963; 29: 91-8.
26. Sridevi M , S.Subramanian. Hypoglycemic effect of Solanum surattense leaf-extract in streptozotocin induced diabetic rat. J Pharmacol Toxicol 2007; 6: 621-9.
27. Swanson MA. Glucose-6-phosphatase from liver. In: Colowick SP, Kaplan NO, eds. Methods in Enzymology. New York: Academic press, 1955: 541-3.
28. Turner MA. Screening Methods in Pharmacology. New York: Academic Press, 1965.
29. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care.2004; 27: 1047-53.
30. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001; 414: 782-787.