The celiac iceberg: Characterization of the disease in primary schoolchildren

Journal of Pediatric Gastroenterology and Nutrition

Volumn 56, Issue 4, 2013, Pages 416-421

  Nenna, Raffaella ^a   Tiberti, Claudio ^a   Petrarca, Laura ^a   Lucantoni, Federica ^a   Mennini, Maurizio ^a   Luparia, Rita Pia Lara ^a   Panimolle, Francesca ^a   Mastrogiorgio, Gerarda ^a   Pietropaoli, Nicoletta ^a   Magliocca, Fabio Massimo ^a   Bonamico, Margherita ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

anti transglutaminase antibodies; celiac iceberg; children; saliva; screening

Indexed keywords

ENDOMYSIUM ANTIBODY; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY;

ANTIBODY BLOOD LEVEL; ARTICLE; BODY HEIGHT; BODY WEIGHT; CELIAC DISEASE; CHILD; ENDOSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GLUTEN FREE DIET; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SALIVA ANALYSIS; SCHOOL CHILD; SCREENING TEST; SEX DIFFERENCE;

ATROPHY; AUTOANTIBODIES; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DIET, GLUTEN-FREE; DUODENUM; EARLY DIAGNOSIS; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTESTINAL MUCOSA; ITALY; MALE; MASS SCREENING; PREVALENCE; SALIVA; SEVERITY OF ILLNESS INDEX; TRANSGLUTAMINASES;

EID: 84875863782     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e31827b7f64     Document Type: Article

References (30)

1. Viljamaa M, Kaukinen K, Huhtala H, et al. Coeliac disease, autoimmune diseases and gluten exposure. Scand J Gastroenterol 2005;40:437-43.
2. Ansaldi N, Palmas T, Corrias A, et al. Autoimmune thyroid disease and celiac disease in children. J Pediatr Gastroenterol Nutr 2003;37:63-6.
3. Salardi S, Volta U, Zucchini S, et al. Prevalence of celiac disease in children with type 1 diabetes mellitus increased in the mid-1990 s: an 18-year longitudinal study based on anti-endomysial antibodies. J Pediatr Gastroenterol Nutr 2008;46:612-4.
4. Stazi AV, Trecca A, Trinti B. Osteoporosis in celiac disease and in endocrine and reproductive disorders. World J Gastroenterol 2008; 14:498-505.
5. Nenna R, Mennini M, Petrarca L, et al. Immediate effect on fertility of a gluten-free diet in women with untreated coeliac disease. Gut 2011;60:1023-4.
6. Mathus-Vliegen EM, Van Halteren H, Tytgat GN. Malignant lymphoma in celiac disease: various manifestations with distinct symptomatology and prognosis. J Int Med 1994;236:43-9.
7. Bonamico M, Nenna R, Montuori M, et al. First salivary screening of celiac disease by detection of anti-transglutaminase autoantibody radio-immunoassay in 5000 Italian primary schoolchildren. J Pediatr Gastro-enterol Nutr 2011;52:17-20.
8. Bonamico M, Ferri M, Nenna R, et al. Tissue transglutaminase autoanti-body detection in human saliva: a powerful method for celiac disease screening. J Pediatr 2004;144:632-6.
9. Bonamico M, Nenna R, Luparia RP, et al. Radioimmunological detection of anti-transglutaminase autoantibodies in human saliva: a useful test to monitor coeliac disease follow-up. Aliment Pharmacol Ther 2008;28:364-70.
10. Mustalahti K, Lohiniemi S, Collin P, et al. Gluten-free diet and quality of life in patients with screen-detected celiac disease. Eff Clin Pract 2002;5:105-13.
11. Fabiani E, Catassi C, Villari A, et al. Dietary compliance in screening-detected coeliac disease adolescents. Acta Paediatr 1996;412:65-7.
12. Van Doorn RK, Winkler LM, Zwinderman KH, et al. CDDUX: a disease-specific health-related quality-of-life questionnaire for children with celiac disease. J Pediatr Gastroenterol Nutr 2008;47:147-52.
13. Bonamico M, Tiberti C, Picarelli A, et al. Radioimmunoassay to detect antitransglutaminase autoantibodies is the most sensitive and specific screening method for celiac disease. Am J Gastroenterol 2001;96:1536-40.
14. Li M, Yu L, Tiberti C, et al. A report on the International Transglu-taminase Autoantibody Workshop for Celiac Disease. Am J Gastro-enterol 2009;104:154-63.
15. Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005;40:1-19.
16. Rothman KJ. Modern Epidemiology. Boston: Little, Brown; 1994.
17. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999;11:1185-94
18. National Institute of Statistics. http://demo.istat.it/pop2010/index. html.
19. Catassi C, Fabiani E, Rätsch IM, et al. The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatr 1996;412:29-35.
20. Lohi S, Mustalahti K, Kaukinen K, et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther 2007;26: 1217-25.
21. Mustalahti K, Catassi C, Reunanen A, et al. Coeliac EU Cluster, Project Epidemiology. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med 2010; 42:587-95.
22. Tommasini A, Not T, Kiren V, et al. Mass screening for coeliac disease using antihuman transglutaminase antibody assay. Arch Dis Child 2004;89:512-5.
23. Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology 2009;137: 88-93.
24. Bonamico M, Ferri M, Mariani P, et al. Serologic and genetic markers of celiac disease: a sequential study in the screening of first degree relatives. J Pediatr Gastroenterol Nutr 2006;42:150-4.
25. Barton SH, Murray JA. Celiac disease and autoimmunity in the gut and elsewhere. Gastroenterol Clin North Am 2008;37:411-28.
26. Mody RJ, Brown PI, Wechsler DS. Refractory iron deficiency anemia as the primary clinical manifestation of celiac disease. J Pediatr Hematol Oncol 2003;25:169-72.
27. Korponay-Szabó IR, Szabados K, Pusztai J, et al. Population screening for coeliac disease in primary care by district nurses using a rapid antibody test: diagnostic accuracy and feasibility study. BMJ 2007; 335:1244-7.
28. Toscano V, Conti FG, Anastasi E, et al. Importance of gluten in the induction of endocrine autoantibodies and organ dysfunction in adolescent celiac patients. Am J Gastroenterol 2000;95:1742-8.
29. Richter JC, Netzer P, Cottagnoud P, et al. Testing strategies and follow-up for coeliac disease in a general internal medicine outpatient department from 2000 to 2005. Swiss Med Wkly 2006;136:732-8.
30. Cataldo F, Marino V, Bottaro G, et al. Celiac disease and selective immunoglobulin A deficiency. J Pediatr 1997;131:306-8.