Cerebrospinal fluid (1,3)-β-d-glucan detection as an aid for diagnosis of iatrogenic fungal meningitis

Journal of Clinical Microbiology

Volumn 51, Issue 4, 2013, Pages 1285-1287

  Lyons, Jennifer L ^a   Roos, Karen L ^e   Marr, Kieren A ^b,c   Neumann, Henry ^b   Trivedi, Julie B ^b   Kimbrough, Dorlan J ^a   Steiner, Lisa ^b   Thakur, Kiran T ^a   Harrison, Daniel M ^a   Zhang, Sean X ^d,f  

^a Departments of Neurology and Psychiatry   (United States)

^b John Hopkins Medical Instituitions   (United States)

^c Departments of Orthopaedic Surgery and Oncology   (United States)

^d Departments of Pathology   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 1,3 GLUCAN; GALACTOMANNAN; METHYLPREDNISOLONE ACETATE; VORICONAZOLE;

ADULT; AGED; ARTICLE; BRAIN HEMORRHAGE; CARBOHYDRATE ANALYSIS; CAUDA EQUINA; CAVERNOUS HEMANGIOMA; CAVERNOUS MALFORMATION BLEEDING; CEREBROSPINAL FLUID CULTURE; CEREBROSPINAL FLUID EXAMINATION; CEREBROSPINAL FLUID LEVEL; CEREBROSPINAL FLUID PRESSURE; CLINICAL ARTICLE; DIARRHEA; DISKITIS; DRUG CONTAMINATION; DRUG DOSE INCREASE; DRUG WITHDRAWAL; EPIDEMIC; ERYTHROCYTE COUNT; FEMALE; FRONTAL LOBE; FUNGAL CONTAMINATION; FUNGAL MENINGITIS; FUNGUS CULTURE; GLUCOSE CEREBROSPINAL FLUID LEVEL; HEADACHE; HUMAN; IATROGENIC DISEASE; INJECTION SITE EDEMA; INJECTION SITE PAIN; INTRAPARENCHYMAL HEMORRHAGE; LEUKOCYTE COUNT; LEUKOCYTE DIFFERENTIAL COUNT; LUMBAR PUNCTURE; LUMBOSACRAL SPINE; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NAUSEA; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT COMPLIANCE; PLEOCYTOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; SPINE RADIOGRAPHY; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; AGED; BETA-GLUCANS; CEREBROSPINAL FLUID; DRUG CONTAMINATION; FEMALE; HUMANS; IATROGENIC DISEASE; MALE; MENINGITIS, FUNGAL; METHYLPREDNISOLONE; MIDDLE AGED;

EID: 84875862239     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00061-13     Document Type: Article

References (14)

1. Cuetara MS, Alhambra A, Moragues MD, Gonzalez-Elorza E, Ponton J, del Palacio A. 2009. Detection of (1¡3)-beta-D-glucan as an adjunct to diagnosis in a mixed population with uncommon proven invasive fungal diseases or with an unusual clinical presentation. Clin. Vaccine Immunol. 16:423-426.
2. CDC. 2012. Multistate outbreak of fungal infection associated with injection of methylprednisolone acetate solution from a single compounding pharmacy-United States. MMWR Morb. Mortal. Wkly. Rep. 61:839-842.
3. Kainer MA, Reagan DR, Nguyen DB, Wiese AD, Wise ME, Ward J, Park BJ, Kanago ML, Baumblatt J, Schaefer MK, Berger BE, Marder EP, Min JY, Dunn JR, Smith RM, Dreyzehner J, Jones TF. 2012. Fungal infections associated with contaminated methylprednisolone in Tennessee. N. Engl. J. Med. 367:2194-2203.
4. Petraitiene R, Petraitis V, Hope WW, Mickiene D, Kelaher AM, Murray HA, Mya-San C, Hughes JE, Cotton MP, Bacher J, Walsh TJ. 2008. Cerebrospinal fluid and plasma (1¡3)-beta-D-glucan as surrogate markers for detection and monitoring of therapeutic response in experimental hematogenous Candida meningoencephalitis. Antimicrob. Agents Chemother. 52:4121-4129.
5. Kauffman CA, Pappas PG, Patterson TF. 9 October 2012. Fungal infections associated with contaminated methylprednisolone injections-preliminary report. N. Engl. J. Med. [Epub ahead of print.] doi:10.1056/NEJMra1212617.
6. Lyons JL, Gireesh ED, Trivedi JB, Robert Bell W, Cettomai D, Smith BR, Karram S, Chang T, Tochen L, Zhang SX, McCall CM, Pearce DT, Carroll KC, Chen L, Ratchford JN, Harrison DM, Ostrow LW, Stevens RD. 2012. Fatal exserohilum meningitis and central nervous system vasculitis after cervical epidural methylprednisolone injection. Ann. Intern. Med. 157:835-836.
7. Robert Bell W, Dalton JB, McCall CM, Karram S, Pearce DT, Memon W, Lee R, Carroll KC, Lyons JL, Gireesh ED, Trivedi JB, Cettomai D, Smith BR, Chang T, Tochen L, atchford JN, Harrison DM, Ostrow LW, Stevens RD, Chen L, Zhang SX. 7 December 2012. Iatrogenic Exserohilum infection of the central nervous system: Mycological identification and histopathological findings. Mod. Pathol. [Epub ahead of print.] doi: 10.1038/modpathol.2012.208.
8. Smith RM, Schaefer MK, Kainer MA, Wise M, Finks J, Duwve J, Fontaine E, Chu A, Carothers B, Reilly A, Fiedler J, Wiese AD, Feaster C, Gibson L, Griese S, Purfield A, Cleveland AA, Benedict K, Harris JR, Brandt ME, Blau D, Jernigan J, Weber JT, Park BJ, Multistate Fungal Infection Outbreak Response Team. 19 December 2012. Fungal infections associated with contaminated methylprednisolone injections-preliminary report. N. Engl. J. Med. [Epub ahead of print.] doi:10.1056/NEJMoa1213978.
9. Odabasi Z, Mattiuzzi G, Estey E, Kantarjian H, Saeki F, Ridge RJ, Ketchum PA, Finkelman MA, Rex JH, Ostrosky-Zeichner L. 2004. Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: Validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clin. Infect. Dis. 39:199-205.
10. Ostrosky-Zeichner L, Alexander BD, Kett DH, Vazquez J, Pappas PG, Saeki F, Ketchum PA, Wingard J, Schiff R, Tamura H, Finkelman MA, Rex JH. 2005. Multicenter clinical evaluation of the (1¡3) beta-D-glucan assay as an aid to diagnosis of fungal infections in humans. Clin. Infect. Dis. 41:654-659.
11. Igusa R, Narumi S, Murakami K, Kitawaki Y, Tamii T, Kato M, Sato M, Tsuboi M, Ota K. 2012. Escherichia coli pneumonia in combination with fungal sinusitis and meningitis in a tsunami survivor after the Great East Japan Earthquake. Tohoku J. Exp. Med. 227:179-184.
12. Pickering JW, Sant HW, Bowles CA, Roberts WL, Woods GL. 2005. Evaluation of a (1-?3)-?-D-glucan assay for diagnosis of invasive fungal infections. J. Clin. Microbiol. 43:5957-5962.
13. Racil Z, Kocmanova I, Lengerova M, Weinbergerova B, Buresova L, Toskova M, Winterova J, Timilsina S, Rodriguez I, Mayer J. 2010. Difficulties in using 1,3-?-D-glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies-high frequency of false-positive results and their analysis. J. Med. Microbiol. 59:1016-1022.
14. Shupp JW, Petraitiene R, Jaskille AD, Pavlovich AR, Matt SE, Nguyen do, Kath TMA, Jeng JC, Jordan MH, Finkelman M, Walsh TJ, Shoham S. 2012. Early serum (1¡3)-beta-D-glucan levels in patients with burn injury. Mycoses 55:224-227.