Fungal infections associated with contaminated methylprednisolone injections

New England Journal of Medicine

Volumn 369, Issue 17, 2013, Pages 1598-1609

  Smith, Rachel M ^a   Schaefer, Melissa K ^b   Kainer, Marion A ^c   Wise, Matthew ^b   Finks, Jennie ^d   Duwve, Joan ^e   Fontaine, Elizabeth ^f   Chu, Alvina ^g   Carothers, Barbara ^h   Reilly, Amy ⁱ   Fiedler, Jay ^d   Wiese, Andrew D ^c   Feaster, Christine ^e   Gibson, Lex ^f   Griese, Stephanie ^a,j   Purfield, Anne ^a   Cleveland, Angela A ^a   Benedict, Kaitlin ^a   Harris, Julie R ^a   Brandt, Mary E ^a   Blau, Dianna ^b   Jernigan, John ^b   Weber, J Todd ^b   Park, Benjamin J ^a   more..

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^c TENNESSEE DEPARTMENT OF HEALTH   (United States)

^d MICHIGAN DEPARTMENT OF COMMUNITY HEALTH   (United States)

^e INDIANA STATE DEPARTMENT OF HEALTH   (United States)

^f VIRGINIA DEPARTMENT OF HEALTH   (United States)

^g MARYLAND DEPARTMENT OF HEALTH AND MENTAL HYGIENE   (United States)

^h New Jersey Department of Health   (United States)

ⁱ FLORIDA DEPARTMENT OF HEALTH   (United States)

^j North Carolina Division of Public Health   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; METHYLPREDNISOLONE ACETATE; VORICONAZOLE;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DEATH; DRUG RECALL; EXSEROHILUM ROSTRATUM; FEMALE; FUNGAL MENINGITIS; FUNGUS CULTURE; FUNGUS ISOLATION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; INFECTIOUS ARTHRITIS; LABORATORY TEST; LOW BACK PAIN; MAJOR CLINICAL STUDY; MALE; MEDICAL STAFF; MONOTHERAPY; MORBIDITY; MORTALITY; MOULD; MYCOSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE;

EID: 84886295078     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1213978     Document Type: Article

References (39)

1. Staal JB, de Bie RA, de Vet HC, Hildebrandt J, Nelemans P. Injection therapy for subacute and chronic low back pain: an updated Cochrane review. Spine (Phila Pa 1976) 2009;34:49-59.
2. Hooten WM, Kinney MO, Huntoon MA. Epidural abscess and meningitis after epidural corticosteroid injection. Mayo Clin Proc 2004;79:682-6.
3. Cooper AB, Sharpe MD. Bacterial meningitis and cauda equina syndrome after epidural steroid injections. Can J Anaesth 1996;43:471-4.
4. Park MS, Moon SH, Hahn SB, Lee HM. Paraspinal abscess communicated with epidural abscess after extra-articular facet joint injection. Yonsei Med J 2007;48:711-4.
5. Ostensson A, Geborek P. Septic arthritis as a non-surgical complication in rheumatoid arthritis: relation to disease severity and therapy. Br J Rheumatol 1991;30:35-8.
6. Gray RG, Tenenbaum J, Gottlieb NL. Local corticosteroid injection treatment in rheumatic disorders. Semin Arthritis Rheum 1981;10:231-54.
7. Gaul C, Neundörfer B, Winterholler M. Iatrogenic (para-) spinal abscesses and meningitis following injection therapy for low back pain. Pain 2005;116:407-10.
8. Simopoulos TT, Kraemer JJ, Glazer P, Bajwa ZH. Vertebral osteomyelitis: a potentially catastrophic outcome after lumbar epidural steroid injection. Pain Physician 2008;11:693-7.
9. Hoelzer BC, Weingarten TN, Hooten WM, Wright RS, Wilson WR, Wilson PR. Paraspinal abscess complicated by endocarditis following a facet joint injection. Eur J Pain 2008;12:261-5.
10. Kabbara A, Rosenberg SK, Untal C. Methicillin-resistant Staphylococcus aureus epidural abscess after transforaminal epidural steroid injection. Pain Physician 2004;7:269-72.
11. Rodrigo N, Perera KNT, Ranwala R, Jayasinghe S, Warnakulasuriya A, Hapuarachchi S. Aspergillus meningitis following spinal anaesthesia for caesarean section in Colombo, Sri Lanka. Int J Obstet Anesth 2007;16:256-60.
12. Kolbe ABL, McKinney AM, Kendi ATK, Misselt D. Aspergillus meningitis and discitis from low-back procedures in an immunocompetent patient. Acta Radiol 2007;48:687-9.
13. Saigal G, Donovan Post MJ, Kozic D. Thoracic intradural Aspergillus abscess formation following epidural steroid injection. AJNR Am J Neuroradiol 2004;25:642-4.
14. Exophiala infection from contaminated injectable steroids prepared by a compounding pharmacy - United States, July-November 2002. MMWR Morb Mortal Wkly Rep 2002;51:1109-12.
15. Pettit AC, Kropski JA, Castilho JL, et al. The index case for the fungal meningitis outbreak in the United States. N Engl J Med 2012;367:2119-25.
16. Kainer MA, Reagan DR, Nguyen DB, et al. Fungal infections associated with contaminated methylprednisolone in Tennessee. N Engl J Med 2012;367:2194-203.
17. Notes from the field: multistate outbreak of postprocedural fungal endophthalmitis associated with a single compounding pharmacy - United States, March-April 2012. MMWR Morb Mortal Wkly Rep 2012;61:310-1.
18. Civen R, Vugia DJ, Alexander R, et al. Outbreak of Serratia marcescens infections following injection of betamethasone compounded at a community pharmacy. Clin Infect Dis 2006;43:831-7.
19. CDC and FDA joint telebriefing on investigation of meningitis outbreak. Atlanta: Centers for Disease Control and Prevention, October 4, 2012 (http://www.cdc.gov/media/releases/2012/t1004-meningitis-outbreak.html).
20. Archive of updates: fungal meningitis. Silver Spring, MD: Food and Drug Administration, 2012 (http://www.fda.gov/Drugs/DrugSafety/FungalMeningitis/ ucm325037.htm).
21. Multistate fungal meningitis outbreak investigation: laboratory testing and results from the outbreak. Atlanta: Centers for Disease Control and Prevention, 2012 (http://www.cdc.gov/hai/outbreaks/laboratory/lab-testing- results.html).
22. Balajee SA, Kano R, Baddley JW, et al. Molecular identification of Aspergillus species collected for the Transplant-Associated Infection Surveillance Network. J Clin Microbiol 2009;47:3138-41.
23. Interpretive criteria for identification of bacteria and fungi by DNA target sequencing; approved guideline. CLSI document MM18-A. Wayne, PA: Clinical and Laboratory Standards Institute, 2008.
24. Gade L, Scheel CM, Pham CD, et al. Detection of fungal DNA in human body fluids and tissues during a multistate outbreak of fungal meningitis and other infections. Eukaryot Cell 2013;12:677-83.
25. Lockhart SR, Pham CD, Gade L, et al. Fungal infections associated with contaminated methylprednisolone injections - preliminary laboratory report. J Clin Microbiol (in press).
26. Ritter JM, Muehlenbachs A, Blau DM, et al. Exserohilum infections associated with contaminated steroid injections: a clinicopathologic review of 40 cases. Am J Pathol 2013;183:881-92.
27. Verweij PE, Brinkman K, Kremer HP, Kullberg BJ, Meis JF. Aspergillus meningitis: diagnosis by non-culture-based microbiological methods and management. J Clin Microbiol 1999;37:1186-9.
28. Viscoli C, Machetti M, Gazzola P, et al. Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis. J Clin Microbiol 2002;40:1496-9.
29. Gunaratne PS, Wijeyaratne CN, Seneviratne HR. Aspergillus meningitis in Sri Lanka - a post-tsunami effect? N Engl J Med 2007;356:754-6.
30. Adam RD, Paquin ML, Petersen EA, et al. Phaeohyphomycosis caused by the fungal genera Bipolaris and Exserohilum: a report of 9 cases and review of the literature. Medicine (Baltimore) 1986;65:203-17.
31. Douer D, Goldschmied-Reouven A, Segev S, Ben-Bassat I. Human Exserohilum and Bipolaris infections: report of Exserohilum nasal infection in a neutropenic patient with acute leukemia and review of the literature. J Med Vet Mycol 1987;25:235-41.
32. McGinnis MR, Rinaldi MG, Winn RE. Emerging agents of phaeohyphomycosis: pathogenic species of Bipolaris and Exserohilum. J Clin Microbiol 1986;24:250-9.
33. Duquia RP, de Almeida HL Jr, Vettorato G, Rocha NM, de Castro LA. Ecthyma-like phaeohyphomycosis caused by Cladosporium cladosporioides. Mycoses 2010;53:541-3.
34. Chew FL, Subrayan V, Chong PP, Goh MC, Ng KP. Cladosporium cladosporioides keratomycosis: a case report. Jpn J Ophthalmol 2009;53:657-9.
35. Lalueza A, Lopez-Medrano F, del Palacio A, et al. Cladosporium macrocarpum brain abscess after endoscopic ultrasound-guided celiac plexus block. Endoscopy 2011;43:Suppl 2:UCTN:E9-10.
36. Terr AI. Stachybotrys: relevance to human disease. Ann Allergy Asthma Immunol 2001;87:Suppl 3:57-63.
37. Smith RM, Tipple M, Chaudry MN, Schaefer MK, Park BJ. Relapse of fungal meningitis associated with contaminated methylprednisolone. N Engl J Med 2013;368:2535-6.
38. Medprep Consulting Inc. announces voluntary nationwide recall of all lots of magnesium sulfate 2 gm in dextrose 5% in water, 50 ml for injection due to mold contamination. Silver Spring, MD: Food and Drug Administration, March 16, 2013 (http://www.fda.gov/Safety/Recalls/ucm344189.htm).
39. Main Street Family Pharmacy. LLC issues voluntary nationwide recall of all sterile compounded products. Silver Spring, MD: Food and Drug Administration, May 28, 2013 (http://www.fda.gov/Safety/Recalls/ucm354182.htm).