The relationship between copper, homocysteine and early vascular disease in lean women with polycystic ovary syndrome

Gynecological Endocrinology

Volumn 29, Issue 5, 2013, Pages 488-491

  Celik, Cem ^a   Bastu, Ercan ^b   Abali, Remzi ^a   Alpsoy, Seref ^c   Guzel, Eda Celik ^c   Aydemir, Birsen ^d   Yeh, John ^e  

^a NAMIK KEMAL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c SAKARYA UNIVERSITY   (Turkey)

^d ISTANBUL UNIVERSITY   (Turkey)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Brachial artery flow mediated dilation; Carotid intima media thickness; Copper; Homocysteine; Polycystic ovary syndrome

Indexed keywords

COPPER; FOLLITROPIN; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; PRASTERONE SULFATE; TRIACYLGLYCEROL;

ADULT; AMENORRHEA; ARTERIAL WALL THICKNESS; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTICLE; BODY MASS; BRACHIAL ARTERY; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; COPPER BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLICULAR PHASE; FOLLITROPIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LEAN BODY WEIGHT; LUTEINIZING HORMONE BLOOD LEVEL; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR DISEASE; WAIST HIP RATIO;

ADULT; BRACHIAL ARTERY; CAROTID INTIMA-MEDIA THICKNESS; CASE-CONTROL STUDIES; COPPER; ENDOTHELIUM, VASCULAR; FEMALE; HOMOCYSTEINE; HUMANS; POLYCYSTIC OVARY SYNDROME; REGRESSION ANALYSIS; THINNESS; VASCULAR DISEASES; VASODILATION; YOUNG ADULT;

EID: 84875823349     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2013.774361     Document Type: Article

References (27)

1. Ehrmann DA. Polycystic ovary syndrome. N Engl Med 2005;352: 1223
2. Orio Jr F, Palomba S, Cascella T, et al. Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004;89: 4588-93. (Pubitemid 39244474)
3. Tiras MB, Yalcin R, Noyan V, et al. Alterations in cardiac flow parameters in patients with polycystic ovarian syndrome. Human Reprod 1999;14:1949-52. (Pubitemid 29381224)
4. Kelly CJ, Speirs A, Gould GW, et al. Altered vascular function in young women with polycystic ovary sydrome. J Clin Endocrinol Metab 2002;87:742-6. (Pubitemid 34158246)
5. Zou CG, Banerje R. Homocysteine and redox signaling. Antioxid Redox Signal 2005;7:547-59.
6. Fonseca V, Guba SC, Fink LM. Hyperhomocysteinemia and the endocrine system: implications for atherosclerosis and thrombosis. Endocr Rev 1999;20:738-59. (Pubitemid 30650604)
7. Tawakol A, Omland T, Gerhard M, et al. Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 1997;95:1119-21. (Pubitemid 27097819)
8. Dudman NPB, Wilcken DEL. Increased plasma copper in patients with homocystinuria due to cystathiamine b-synthase deficiency. Clin Chim Acta 1983;127:105-13.
9. Aalbers THG, Houtman JPW. Relationship between trace elements and atherosclerosis. Sci Tot Environ 1981;43:255-83.
10. Mansoor MA, Bergmark C, Haswell SJ, et al. Correlation between plasma total homocysteine and copper in patients with peripheral vascular disease. Clin Chem 2000;46:385-91. (Pubitemid 30152265)
11. Shukla N, Angelini GD, Jeremy JY. Interactive effects of homocysteine and copper on angiogenesis in porcine isolated saphenous vein. Ann Thorac Surg 2007;84:43-9. (Pubitemid 46921154)
12. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19:41-7.
13. Coskun A, Ercan O, Arikan DC, et al. Modified Ferriman-Gallwey hirsutism score and androgen levels in Turkish women. Eur J Obstet Gynecol Reprod Biol 2011;154:167-71.
14. Liang Y, Teede H, Kotsopoulos D, et al. Non-invasive measurements of arterial structure and function: repeatability, interrelationships and trial sample size. Clin Sci 1998;95:669-79. (Pubitemid 29034431)
15. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9. (Pubitemid 15018832)
16. Dokras A. Cardiovascular disease risk factors in polycystic ovary syndrome. Semin Reprod Med 2008;26:39-44.
17. Wild RA. Long-term health consequences of PCOS. Hum Reprod Update 2002;8:231-41. (Pubitemid 34618942)
18. Berwanger CL, Jeremy JY, Stansby GD. Homocysteine and vascular disease. Br J Surg 1995;82:726-31.
19. Loverro G, Lorusso F, Mei L, et al. The plasma homocysteine levels are increased in polycystic ovary syndrome. Gynecol Obstet Invest 2002;53:157-62. (Pubitemid 34621637)
20. Orio F, Palomba S, Di Biase S, et al. Homocysteine levels and C677T polymorphism of methylenetetrahydrofolate reductase in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2003;88:673-9. (Pubitemid 36207807)
21. Boulman N, Levy Y, Leiba R, et al. Increased C-reactive protein levels in the polycystic ovary syndrome: a marker of cardiovascular disease. J Clin Endocrinol Metab 2004;89:2160-5. (Pubitemid 38619847)
22. Linnebank M, Lutz H, Jarre E, et al. Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells. Neurobiol Dis 2006;23:725-30. (Pubitemid 44234108)
23. Emsley AM, Jeremy JY, Gomes GN, et al. Investigation of the inhibitory effects of homocysteine and copper on nitric oxidemediated relaxation of rat isolated aorta. Brit J Pharm 1999;126: 1034-40. (Pubitemid 29103721)
24. Kinsman GD, Howard AN, Stone DL, Mullins PA. Studies in copper status and atherosclerosis. Biochem Soc Trans 1990;18: 1186-8.
25. Kurdoglu Z, Kurdoglu M, Demir H, Sahin HG. Serum trace elements and heavy metals in polycystic ovary syndrome. Human Exp Toxicol 2012;31:452-6.
26. Wofford J, Kahl F, Howard G, et al. Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis. Arteroscler Thromb Vasc Biol 1991;11:1786-94.
27. Palomba S, Falbo A, Giallauria F, et al. Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome. Diabetes Care 2010;33:246-51.