Identification and description of a novel murine model for polytrauma and shock

Critical Care Medicine

Volumn 41, Issue 4, 2013, Pages 1075-1085

  Gentile, Lori F ^a   Nacionales, Dina C ^a   Cuenca, Alex G ^a   Armbruster, Michael ^a   Ungaro, Ricardo F ^a   Abouhamze, Amer S ^a   Lopez, Cecelia ^a   Baker, Henry V ^a   Moore, Frederick A ^a   Ang, Darwin N ^a   Efron, Philip A ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

femur fracture; gene expression; hemorrhage; immune suppression; inflammation; trauma

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTERY CATHETERIZATION; ARTICLE; BLEEDING; CELL ACTIVATION; CONTROLLED STUDY; FEMUR FRACTURE; GENE EXPRESSION; HEMORRHAGIC SHOCK; IN VIVO STUDY; LAPAROTOMY; LYMPHOCYTE ACTIVATION; MALE; MEAN ARTERIAL PRESSURE; MICROARRAY ANALYSIS; MONOCYTE; MOUSE; MULTIPLE TRAUMA; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESUSCITATION; SHAM PROCEDURE; SHOCK;

ACUTE KIDNEY INJURY; ANIMALS; BRAIN INJURIES; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DISEASE MODELS, ANIMAL; FRACTURES, BONE; LIVER DISEASES; MICE; MICE, INBRED C57BL; MULTIPLE TRAUMA; SHOCK, HEMORRHAGIC; SPLEEN;

EID: 84875813677     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318275d1f9     Document Type: Article

References (36)

1. Pfeifer R, Tarkin IS, Rocos B, et al: Patterns of mortality and causes of death in polytrauma patients-Has anything changed? Injury 2009; 40:907-911
2. Deitch EA: Animal models of sepsis and shock: A review and lessons learned. Shock 1998; 9:1-11
3. Probst C, Pape HC, Hildebrand F, et al: 30 years of polytrauma care: An analysis of the change in strategies and results of 4849 cases treated at a single institution. Injury 2009; 40:77-83
4. Levy RM, Prince JM, Yang R, et al: Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor Am J Physiol Regul Integr Comp Physiol 2006; 291:R970-R976
5. Xiao W, Mindrinos MN, Seok J, et al; Inflammation and Host Response to Injury Large-Scale Collaborative Research Program: A genomic storm in critically injured humans. J Exp Med 2011; 208:2581-2590
6. Giannoudis PV, Hildebrand F, Pape HC: Inflammatory serum markers in patients with multiple trauma. Can they predict outcome? J Bone Joint Surg Br 2004; 86:313-323
7. Gentile LF, Cuenca AG, Efron PA, et al: Persistent inflammation and immunosuppression: A common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg 2012; 72:1491-1501
8. Ciesla DJ, Moore EE, Johnson JL, et al: A 12-year prospective study of postinjury multiple organ failure: Has anything changed? Arch Surg 2005; 140:432-438; discussion 438
9. Wang P, Ba ZF, Burkhardt J, et al: Trauma-hemorrhage and resuscitation in the mouse: Effects on cardiac output and organ blood flow. Am J Physiol 1993; 264(4 Pt 2):H1166-H1173
10. Gill R, Ruan X, Menzel CL, et al: Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells. Shock 2011; 35:164-170
11. Venet F, Chung CS, Huang X, et al: Lymphocytes in the development of lung inflammation: A role for regulatory CD4+ T cells in indirect pulmonary lung injury. J Immunol 2009; 183:3472-3480
12. Wichmann MW, Ayala A, Chaudry IH: Severe depression of host immune functions following closed-bone fracture, soft-tissue trauma, and hemorrhagic shock. Crit Care Med 1998; 26:1372-1378
13. Matsutani T, Kang SC, Miyashita M, et al: Young and middle-age associated differences in cytokeratin expression after bone fracture, tissue trauma, and hemorrhage. Am J Surg 2007; 193:61-68
14. Maddali S, Stapleton PP, Freeman TA, et al: Neuroendocrine responses mediate macrophage function after trauma. Surgery 2004; 136:1038-1046
15. Kang SC, Matsutani T, Choudhry MA, et al: Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage? Cytokine 2004; 26:223-230
16. Keel M, Trentz O: Pathophysiology of polytrauma. Injury 2005; 36:691-709
17. Levy MM, Dellinger RP, Townsend SR, et al: The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med 2010; 36:222-231
18. Cuschieri J, Johnson JL, Sperry J, et al; Inflammation and Host Response to Injury, Large Scale Collaborative Research Program: Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg 2012; 255:993-999
19. McKinley BA, Moore LJ, Sucher JF, et al: Computer protocol facilitates evidence-based care of sepsis in the surgical intensive care unit. J Trauma 2011; 70:1153-1166; discussion 1166
20. Baker SP, O'Neill B, Haddon W Jr, et al: The injury severity score: A method for describing patients with multiple injuries and evaluating emergency care. J Trauma 1974; 14:187-196
21. Knöferl MW, Jarrar D, Angele MK, et al: 17 beta-Estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhage. Am J Physiol Cell Physiol 2001; 281:C1131-C1138
22. Kelly-Scumpia KM, Scumpia PO, Weinstein JS, et al: B cells enhance early innate immune responses during bacterial sepsis. J Exp Med 2011; 208:1673-1682
23. Lederer JA, Brownstein BH, Lopez MC, et al; Inflammation and the Host Response to Injury Collaborative Research Program Participants: Comparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice. Physiol Genomics 2008; 32:299-310
24. Menges T, Engel J, Welters I, et al: Changes in blood lymphocyte populations after multiple trauma: Association with posttraumatic complications. Crit Care Med 1999; 27:733-740
25. Walsh DS, Siritongtaworn P, Pattanapanyasat K, et al: Lymphocyte activation after non-thermal trauma. Br J Surg 2000; 87:223-230
26. Delano MJ, Scumpia PO, Weinstein JS, et al: MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med 2007; 204: 1463-1474
27. Hershman MJ, Cheadle WG, Wellhausen SR, et al: Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br J Surg 1990; 77:204-207
28. Hotchkiss RS, Tinsley KW, Swanson PE, et al: Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol 2002; 168:2493-2500
29. Cuenca AG, Gentile LF, Lopez MC, et al. the Inflammation and Host Response to Injury Collaborative Research Program Development of a Genomic Metric That Can Be Rapidly Used to Predict Clinical Outcome in Severely Injured Trauma Patients. Crit Care Med 2013 Feb 5. [Epub ahead of print]
30. Stahel PF, Smith WR, Moore EE: Role of biological modifiers regulating the immune response after trauma. Injury 2007; 38:1409-1422
31. Menzel CL, Pfeifer R, Darwiche SS, et al: Models of lower extremity damage in mice: Time course of organ damage and immune response. J Surg Res 2011; 166:e149-e156
32. Zellweger R, Ayala A, Zhu XL, et al: Effect of surgical trauma on splenocyte and peritoneal macrophage immune function. J Trauma 1995; 39:645-650
33. Stephan RN, Saizawa M, Conrad PJ, et al: Depressed antigen presentation function and membrane interleukin-1 activity of peritoneal macrophages after laparotomy. Surgery 1987; 102:147-154
34. Ertel W, Keel M, Marty D, et al: [Significance of systemic inflammation in 1,278 trauma patients]. Unfallchirurg 1998; 101:520-526
35. MacLean LD, Meakins JL, Taguchi K, et al: Host resistance in sepsis and trauma. Ann Surg 1975; 182:207-217
36. Oberholzer A, Oberholzer C, Moldawer LL: Sepsis syndromes: Understanding the role of innate and acquired immunity. Shock 2001; 16:83-96