Nominal association with CHRNA4 variants and nicotine dependence

Genes, Brain and Behavior

Volumn 12, Issue 3, 2013, Pages 297-304

  Kamens, H M ^a   Corley, R P ^a   Mcqueen, M B ^a   Stallings, M C ^a   Hopfer, C J ^b   Crowley, T J ^b   Brown, S A ^c   Hewitt, J K ^a   Ehringer, M A ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Association study; DSM IV nicotine dependence; Nicotine; Nicotinic acetylcholine receptors

Indexed keywords

NICOTINIC RECEPTOR ALPHA4; NICOTINIC RECEPTOR BETA2;

ADULT; ANTISOCIAL BEHAVIOR; ARTICLE; DRUG ABUSE; DSM-IV; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOM; TOBACCO DEPENDENCE;

ADOLESCENT; ADULT; ALLELES; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; LONGITUDINAL STUDIES; MALE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, NICOTINIC; TOBACCO USE DISORDER;

ANIMALIA;

EID: 84875803779     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/gbb.12021     Document Type: Article

References (47)

1. Anchordoquy, H.C., McGeary, C., Liu, L., Krauter, K.S. & Smolen, A. (2003) Genotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cells. Behav Genet 33, 73-78.
2. Arias, H.R., Bhumireddy, P. & Bouzat, C. (2006) Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors. Int J Biochem Cell Biol 38, 1254-1276.
3. Barrett, J.C., Fry, B., Maller, J. & Daly, M.J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265.
4. Breitling, L.P., Dahmen, N., Mittelstrass, K., Rujescu, D., Gallinat, J., Fehr, C., Giegling, I., Lamina, C., Illig, T., Muller, H., Raum, E., Rothenbacher, D., Wichmann, H.E., Brenner, H. & Winterer, G. (2009) Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans. Pharmacogenomics J 9, 219-224.
5. Chu, C.J., Yang, Y.C., Wei, J.X. & Zhang, L. (2011) Association of nicotinic acetylcholine receptor subunit alpha-4 polymorphisms with smoking behaviors in Chinese male smokers. Chin Med J (Engl) 124, 1634-1638.
6. Conti, D.V., Lee, W., Li, D., Liu, J., Van Den Berg, D., Thomas, P.D., Bergen, A.W., Swan, G.E., Tyndale, R.F., Benowitz, N.L. & Lerman, C. (2008) Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Hum Mol Genet 17, 2834-2848.
7. Corrigall, W.A., Coen, K.M. & Adamson, K.L. (1994) Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area. Brain Res 653, 278-284.
8. Cottler, L.B. & Keating, S.K. (1990) Operationalization of alcohol and drug dependence criteria by means of a structured interview. Recent Dev Alcohol 8, 69-83.
9. Ehringer, M.A., Clegg, H.V., Collins, A.C., Corley, R.P., Crowley, T., Hewitt, J.K., Hopfer, C.J., Krauter, K., Lessem, J., Rhee, S.H., Schlaepfer, I., Smolen, A., Stallings, M.C., Young, S.E. & Zeiger, J.S. (2007) Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet 144B, 596-604.
10. Ehringer, M.A., McQueen, M.B., Hoft, N.R., Saccone, N.L., Stitzel, J.A., Wang, J.C. & Bierut, L.J. (2010) Association of CHRN genes with "dizziness" to tobacco. Am J Med Genet B Neuropsychiatr Genet 153B, 600-609.
11. Etter, J.F., Hoda, J.C., Perroud, N., Munafo, M., Buresi, C., Duret, C., Neidhart, E., Malafosse, A. & Bertrand, D. (2009) Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. Addict Behav 34, 772-775.
12. Feng, Y., Niu, T., Xing, H., Xu, X., Chen, C., Peng, S., Wang, L. & Laird, N. (2004a) A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am J Hum Genet 75, 112-121.
13. Feng, Y., Niu, T., Xing, H., Xu, X., Chen, C., Peng, S., Wang, L., Laird, N. & Xu, X. (2004b) A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am J Hum Genet 75, 112-121.
14. Grant, B.F., Hasin, D.S., Chou, S.P., Stinson, F.S. & Dawson, D.A. (2004) Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. Arch Gen Psychiatry 61, 1107-1115.
15. Greenbaum, L., Kanyas, K., Karni, O., Merbl, Y., Olender, T., Horowitz, A., Yakir, A., Lancet, D., Ben-Asher, E. & Lerer, B. (2006) Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes. Mol Psychiatry 11, 312-322 223.
16. Grucza, R.A., Wang, J.C., Stitzel, J.A. et al. (2008) A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. Biol Psychiatry 64, 922-929.
17. Han, S., Yang, B.Z., Kranzler, H.R., Oslin, D., Anton, R. & Gelernter, J. (2011) Association of CHRNA4 polymorphisms with smoking behavior in two populations. Am J Med Genet B Neuropsychiatr Genet 156B, 421-429.
18. Hoft, N.R., Stitzel, J.A., Hutchison, K.E. & Ehringer, M.A. (2011) CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. Genes Brain Behav 10, 176-185.
19. Hutchison, K.E., Allen, D.L., Filbey, F.M., Jepson, C., Lerman, C., Benowitz, N.L., Stitzel, J., Bryan, A., McGeary, J. & Haughey, H.M. (2007) CHRNA4 and tobacco dependence: from gene regulation to treatment outcome. Arch Gen Psychiatry 64, 1078-1086.
20. Jackson, K.J., Kota, D.H., Martin, B.R. & Damaj, M.I. (2009) The role of various nicotinic receptor subunits and factors influencing nicotine conditioned place aversion. Neuropharmacology 56, 970-974.
21. King, D.P., Paciga, S., Pickering, E., Benowitz, N.L., Bierut, L.J., Conti, D.V., Kaprio, J., Lerman, C. & Park, P.W. (2012) Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials. Neuropsychopharmacology 37, 641-650.
22. Laird, N.M., Horvath, S. & Xu, X. (2000) Implementing a unified approach to family-based tests of association. Genet Epidemiol 19 (Suppl. 1), S36-S42.
23. Li, M.D., Beuten, J., Ma, J.Z., Payne, T.J., Lou, X.Y., Garcia, V., Duenes, A.S., Crews, K.M. & Elston, R.C. (2005) Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Hum Mol Genet 14, 1211-1219.
24. Liu, X., Palmatier, M.I., Caggiula, A.R., Donny, E.C. & Sved, A.F. (2007) Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats. Psychopharmacology (Berl) 194, 463-473.
25. Lueders, K.K., Hu, S., McHugh, L., Myakishev, M.V., Sirota, L.A. & Hamer, D.H. (2002) Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2). Nicotine Tob Res 4, 115-125.
26. McGehee, D.S. (1999) Molecular diversity of neuronal nicotinic acetylcholine receptors. Ann N Y Acad Sci 868, 565-577.
27. Perkins, K.A., Lerman, C., Mercincavage, M., Fonte, C.A. & Briski, J.L. (2009) Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch. Cancer Epidemiol Biomarkers Prev 18, 2608-2612.
28. Picciotto, M.R., Zoli, M., Lena, C., Bessis, A., Lallemand, Y., Le Novere, N., Vincent, P., Pich, E.M., Brulet, P. & Changeux, J.P. (1995) Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 374, 65-67.
29. Picciotto, M.R., Zoli, M., Rimondini, R., Lena, C., Marubio, L.M., Pich, E.M., Fuxe, K. & Changeux, J.P. (1998) Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature 391, 173-177.
30. Pons, S., Fattore, L., Cossu, G., Tolu, S., Porcu, E., McIntosh, J.M., Changeux, J.P., Maskos, U. & Fratta, W. (2008) Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration. J Neurosci 28, 12318-12327.
31. Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A., Bender, D., Maller, J., Sklar, P., de Bakker, P.I., Daly, M.J. & Sham, P.C. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81, 559-575.
32. Rakovski, C.S., Xu, X., Lazarus, R., Blacker, D. & Laird, N.M. (2007) A new multimarker test for family-based association studies. Genet Epidemiol 31, 9-17.
33. Robins, L.N., Cottler, L.B., Bucholz, K.K., Compton, W.M., North, C.S. & Rourke, K.M. (2000). Diagnostic Interview Schedule for the DSM-IV (DIS-IV). Washington University School of Medicine, St. Louis, MO.
34. Saccone, N.L., Saccone, S.F., Hinrichs, A.L., Stitzel, J.A., Duan, W., Pergadia, M.L., Agrawal, A., Breslau, N., Grucza, R.A., Hatsukami, D., Johnson, E.O., Madden, P.A., Swan, G.E., Wang, J.C., Goate, A.M., Rice, J.P. & Bierut, L.J. (2009) Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am J Med Genet B Neuropsychiatr Genet 150B, 453-466.
35. Saccone, N.L., Schwantes-An, T.H., Wang, J.C., Grucza, R.A., Breslau, N., Hatsukami, D., Johnson, E.O., Rice, J.P., Goate, A.M. & Bierut, L.J. (2010) Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes Brain Behav 9, 741-750.
36. Shaffer, D., Fisher, P., Lucas, C.P., Dulcan, M.K. & Schwab-Stone, M.E. (2000) NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39, 28-38.
37. Sherva, R., Kranzler, H.R., Yu, Y., Logue, M.W., Poling, J., Arias, A.J., Anton, R.F., Oslin, D., Farrer, L.A. & Gelernter, J. (2010) Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Neuropsychopharmacology 35, 1921-1931.
38. Silverman, M.A., Neale, M.C., Sullivan, P.F., Harris-Kerr, C., Wormley, B., Sadek, H., Ma, Y., Kendler, K.S. & Straub, R.E. (2000) Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence. Am J Med Genet 96, 646-653.
39. Stallings, M.C., Corley, R.P., Hewitt, J.K., Krauter, K.S., Lessem, J.M., Mikulich, S.K., Rhee, S.H., Smolen, A., Young, S.E. & Crowley, T.J. (2003) A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. Drug Alcohol Depend 70, 295-307.
40. Stallings, M.C., Corley, R.P., Dennehey, B., Hewitt, J.K., Krauter, K.S., Lessem, J.M., Mikulich-Gilbertson, S.K., Rhee, S.H., Smolen, A., Young, S.E. & Crowley, T.J. (2005) A genome-wide search for quantitative trait loci that influence antisocial drug dependence in adolescence. Arch Gen Psychiatry 62, 1042-1051.
41. Tapper, A.R., McKinney, S.L., Nashmi, R., Schwarz, J., Deshpande, P., Labarca, C., Whiteaker, P., Marks, M.J., Collins, A.C. & Lester, H.A. (2004) Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science 306, 1029-1032.
42. Tapper, A.R., McKinney, S.L., Marks, M.J. & Lester, H.A. (2007) Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice. Physiol Genomics 31, 422-428.
43. Tsai, S.J., Yeh, H.L., Hong, C.J., Liou, Y.J., Yang, A.C., Liu, M.E. & Hwang, J.P. (2012) Association of CHRNA4 polymorphism with depression and loneliness in elderly males. Genes Brain Behav 11, 230-234.
44. Walters, C.L., Brown, S., Changeux, J.P., Martin, B. & Damaj, M.I. (2006) The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice. Psychopharmacology (Berl) 184, 339-344.
45. Wang, J.C., Grucza, R., Cruchaga, C. et al. (2008) Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Mol Psychiatry 14, 501-510.
46. Wessel, J., McDonald, S.M., Hinds, D.A., Stokowski, R.P., Javitz, H.S., Kennemer, M., Krasnow, R., Dirks, W., Hardin, J., Pitts, S.J., Michel, M., Jack, L., Ballinger, D.G., McClure, J.B., Swan, G.E. & Bergen, A.W. (2010) Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstrom test for nicotine dependence. Neuropsychopharmacology 35, 2392-2402.
47. Xie, P., Kranzler, H.R., Krauthammer, M., Cosgrove, K.P., Oslin, D., Anton, R.F., Farrer, L.A., Picciotto, M.R., Krystal, J.H., Zhao, H. & Gelernter, J. (2011) Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biol Psychiatry 70, 528-536.