Effect of the isoflavone genistein on tumor size, metastasis potential and melanization in a B16 mouse model of murine melanoma

Natural Product Communications

Volumn 8, Issue 3, 2013, Pages 343-346

  Danciu, Corina ^a   Borcan, Florin ^a   Bojin, Florina ^a   Zupko, Istvan ^b   Dehelean, Cristina ^a  

^a VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

B164A5; C57BL 6J; Genistein; Melanin; Metastasis; Tumor

Indexed keywords

GENISTEIN; MELANIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DRUG SCREENING; ERYTHEMA; FEMALE; HISTOPATHOLOGY; IN VIVO STUDY; LIVER METASTASIS; MELANOGENESIS; MELANOMA; MELANOMA CELL; METASTASIS INHIBITION; METASTASIS POTENTIAL; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; TREATMENT OUTCOME; TUMOR VOLUME;

EID: 84875787709     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1300800318     Document Type: Article

References (41)

1. Barnes S, Peterson TG, Coward L. (1995) Rationale for the use of genistein-containing soy matrices in chemoprevention trials for breast and prostate cancer. Journal of Cellular Biochemistry Supplement, 22, 181-187.
2. Wei H, Bowen R, Zhang X, Lebwohl M. (1998) Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice. Carcinogen, 19, 1509-1514.
3. Dalais FS, Ebeling PR, Kotsopoulos D, McGrath BP, Teede HJ. (2003) The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women. Clinical Endocrinology, 58, 704-709.
4. Neelakandan C, Chang T, Alexander T, Define L, Evancho-Chapman M, Kyu T. (2011) In vitro evaluation of antioxidant and anti-inflammatory properties of genistein-modified hemodialysis membranes. Biomacromolecules, 12, 2447-2455.
5. Gottstein N, Ewins BA, Eccleston C, Hubbard GP, Kavanagh IC, Minihane AM, Weinberg PD, Rimbach G. (2003) Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial function. British Journal of Nutrition, 89, 607-615.
6. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y.(1987) Genistein, a specific inhibitor of tyrosinespecific protein kinases. Journal of Biological Chemistry, 262, 5592-5595.
7. Polkowski K, Mazurek AP. (2000) Biological properties of genistein. A review of in vitro and in vivo data. Acta Poloniae Pharmaceutica, 57, 135-155.
8. Schmidt F, Knobbe CB, Frank B, Wolburg H, Weller M. (2008) The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. Oncology Reports, 19, 1061-1066.
9. Makishima M, Honma Y, Sampi K, Hattori M, Umezawa K, Motoyoshi K.(1991) Effects of inhibitors of protein tyrosine kinase activity and/or phosphatidylinositol turnover on differentiation of some human myelomonocytic leukemia cells. Leukemia Research, 15, 701-708.
10. Yazaki K. (2006) ABC transporters involved in the transport of plant secondary metabolites. FEBS Letters, 580, 1183-1191.
11. Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM, Simmen RCM. (2005) The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogen, 26, 1793-1803.
12. Baxa DM, Luo X, Yoshimura FK. (2002) Genistein induces apoptosis in T lymphoma cells via mitochondrial damage. Nutrition and Cancer, 51, 93-101.
13. Li Y, Sarkar FH. (2002) Inhibition of nuclear factor κb activation in pc3 cells by genistein is mediated via akt signaling pathway. Clinical Cancer Research, 8, 2369-2377.
14. Dahlman-Wright K, Cavailles V, Fuqua SA, Jordan VC, Katzenellenbogen JA, Korach KS, Maggi A, Muramatsu M, Parker MG, Gustafsson JA. (2006) International union of pharmacology LXIV. Estrogen receptors. Pharmacological Reviews, 58, 773-781.
15. Davis SR, Murkies AL, Wilcox G. (1998) Phytoestrogens in clinical practice. Integrative Medicine, 1, 27-34.
16. Wallace JL, Foy D, Yousuf H, Warnock M, Gow IF. (2012)The effect of 17β oestradiol, resveratrol, and genistein on Na+/H+ exchange in breast cancer cells lines. Proceedings of the Nutrition Society, 71:(OCE1), E10,doi:10.1017/S0029665112000389.
17. Ullah MF, Ahmad A, Zubair H, Khan HY, Wang Z, Sarkar FH, Haid SM. (2011) Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species. Molecular Nutrition & Food Research, 55, 553-559.
18. Merchant K, Kumi-Diaka J, Rathinavelu A, Esiobu N, Zoeller R, Hartmann J, Johnson M. (2011) Molecular basis of the anti-cancer effects of genisteinisoflavone in LNCaP prostate cancer cells. Functional Foods in Health and Disease, 1, 91-105.
19. Shao MZ, Wu J, Shen ZZ, Barsky SH. (1998) Genistein exerts multiple suppressive effects on human breast carcinoma cells. Cancer Research, 58, 4851-4857.
20. Diaka JK. (2002) Chemosensitivity of human prostate cancer cells PC3 and LNCaP to genistein isoflavone and β-lapachone. Biology of the Cell, 94, 37-44.
21. Record IR, Broadbent JL, King RA, Dreosti IE, Head RJ, Tonkin AL. (1997) Genistein inhibits growth of B16 melanoma cells in vivo and in vitro and promotes differentiation in vitro. International Journal of Cancer, 72, 860-864.
22. Teicher BA. (2002) Tumor models in cancer research, InB16 Murine Melanoma. Alvarez E (Ed.), Humana press Inc, New Jersey, 73-87.
23. Nathanson SD, Haas GP, Mead MJ, Lee M. (1986) Spontaneous regional lymph node metastases of three variants of the B16 melanoma: Relationship to primary tumor size and pulmonary metastasis. Journal of Surgical Oncology, 33, 41-45.
24. Ciurlea SA, Tiulea C, Csanyi E, Berko S, Toma CC, Dehelean C, Loghin F. (2010) A pharmatoxicological evaluation of a betulin topical formulation tested on C57BL/6J mouse experimental nevi and skin lesions. Studia Universitatis, 20, 5-9.
25. Yamashita T, Kuwahara T, González S, Takahashi M. (2005) Non-invasive visualization of melanin and melanocytes by reflectance-mode confocal microscopy. Journal of Investigative Dermatology, 124, 235-240.
26. Hoshino T, Matsuda M, Yamashita Y, Takehara M, Fukuya M, Mineda K, Maji D, Ihn H, Adachi H, Sobue G, Funasaka Y, Mizushima T. (2010) Suppression of melanin production by expression of hsp70. The Journal of Biological Chemistry, 285, 13254-13263
27. Matts PJ, Dykes PJ, Marks R. (2007) The distribution of melanin in skin determined in vivo. British Journal of Dermatology, 156, 620-628.
28. Yang CH, Shen SC, Lee JC, Wu PC, Hsueh SF, Lu CY, Meng CT, Hong HS, Yang LC. (2004) Seeing the gene therapy: application of gene gun technique to transfect and decolour pigmented rat skin with human agouti signaling protein Cdna. Gene Therapy, 11, 1033-1039.
29. Jang HS, Choi HC, Hong RH, Kang SM. (2008) The effect of genistein on melanin synthesis and in vivo whitening. Korean Journal of Microbiology and Biotechnology, 36, 72-81.
30. Aster J, Vinay K, Abul KA, Nelson F. (2009) Robbins & Cotran Pathologic Basis of Disease (8th ed.), Saunders, Philadelphia.
31. Shyong EQ, Lu Y, Lazinsky A, Saladi RN, Phelps RG, Austin LM, Lebwohl M, Wei H. (2002) Effects of the 4,5,7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage. Carcinogen, 23, 317-321.
32. Wei H, Saladi R, Lu Y, Wang Y, Palep SR, Moore J, Phelps R, Shyong E, Lebwohl MG. (2003) Isoflavone genistein: photoprotection and clinical implications in dermatology. Journal of Nutrition, 133, 3811S-3819S.
33. Sun BS, Whang JH, Liu LL, Gong SL, Redmon HP. (2007) Taurolidine induces apoptosis of murine melanoma cells in vitro and in vivo by modulation of the Bcl-2 family proteins. Journal of Surgical Oncology, 96, 241-248.
34. Wells JW, Cowled CJ, Farzaneh F, Noble A. (2008) Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. Journal of Immunology, 181, 3422-3431.
35. Yan CH, Chen XG, Li Y, Han R. (1999) Effects of genistein, a soybean-derived isoflavone, on proliferation and differentiation of B16-BL6 mouse melanoma cells. Journal of Asian Natural Product Research, 1, 285-299.
36. Hsu MY, Elder D, Herlyn M. (2002) Human cell culture, melanoma. In The wistar melanoma (WM) cell lines, Volume 1, 259-274.
37. Fukunaga-Kalabis M, Martinez G, Telson SM, Liu ZJ, Balint K, Juhasz I, Elder DE, Perbal B, Herlyn M. (2008) Downregulation of CCN3 expression as a potential mechanism for melanoma progression. Oncogene, 28, 2552-2560.
38. Weinberg R. (2007) The Biology of Cancer. Garland Science, New York
39. Schlüter K, Gassmann P, Enns A, Korb T, Hemping-Bovenkerk A, Hölzen J, Haier J. (2006) Organ-specific metastatic tumor cell adhesion and extravasation of colon carcinoma cells with different metastatic potential. American Journal of Pathology, 169, 1064-1073.
40. Guo TL, McCay JA, Zhang LX, Brown RD, You L, Karrow NA, Germolec DR, White KL. (2001) Genistein modulates immune responses and increases host resistance to b16f10 tumor in adult female b6c3f1 mice. Journal of Nutrition, 131, 3251-3258.
41. Donghua L, John AY, Michael HM, Patricia A, Murphy LY.(1999) Soybean isoflavones reduce experimental metastasis in mice. Journal of Nutrition, 129, 1075-1078.