Epigenetic regulation of NANOG by miR-302 cluster-MBD2 completes induced pluripotent stem cell reprogramming

Stem Cells

Volumn 31, Issue 4, 2013, Pages 666-681

  Lee, Man Ryul ^a   Prasain, Nutan ^a   Chae, Hee Don ^a   Kim, Young June ^a   Mantel, Charlie ^a   Yoder, Mervin C ^a   Broxmeyer, Hal E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epigenetics; Induced pluripotent stem cells; MicroRNA; Reprogramming

Indexed keywords

MICRORNA; MICRORNA 302; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

ARTICLE; GENE CLUSTER; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PATHOGENESIS; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION;

CELLS, CULTURED; EPIGENESIS, GENETIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOPRECIPITATION; INDUCED PLURIPOTENT STEM CELLS; MICRORNAS; NUCLEAR REPROGRAMMING;

IPS;

EID: 84875787631     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1302     Document Type: Article

References (46)

1. Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-872.
2. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.
3. Broxmeyer HE. Will iPS cells enhance therapeutic applicability of cord blood cells and banking? Cell Stem Cell 2010;6:21-24.
4. Broxmeyer HE, Douglas GW, Hangoc G et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci USA 1989;86:3828-3832.
5. Gluckman E, Broxmeyer HA, Auerbach AD et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical- cord blood from an HLA-identical sibling. N Engl J Med 1989; 321:1174-1178.
6. Broxmeyer HE, Smith FO. Cord blood hematopoietic cell transplantation. In: Applebaum FR, Forman SJ, Blume KG, eds. Thomas Hematopoietic Cell Transplantation. 4th ed. Chap 39, UK: Wiley-Blackwell, 2009:559-576.
7. Giorgetti A, Montserrat N, Aasen T et al. Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell 2009;5:353-357.
8. Haase A, Olmer R, Schwanke K et al. Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell 2009;5:434-441.
9. Ye Z, Zhan H, Mali P et al. Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 2009;114:5473-5480.
10. Broxmeyer HE, Lee MR, Hangoc G et al. Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood. Blood 2011;117:4773-4777.
11. Lin T, Ambasudhan R, Yuan X et al. A chemical platform for improved induction of human iPSCs. Nat Methods 2009;6:805-808.
12. Hong H, Takahashi K, Ichisaka T et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009; 460:1132-1135.
13. Marion RM, Strati K, Li H et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 2009;460:1149-1153.
14. Utikal J, Polo JM, Stadtfeld M et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 2009; 460:1145-1148.
15. Hochedlinger K, Plath K. Epigenetic reprogramming and induced pluripotency. Development 2009;136:509-523.
16. Mikkelsen TS, Hanna J, Zhang X et al. Dissecting direct reprogramming through integrative genomic analysis. Nature 2008;454:49-55.
17. Chan EM, Ratanasirintrawoot S, Park IH et al. Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol 2009;27:1033-1037.
18. Subramanyam D, Blelloch R. Watching reprogramming in real time. Nat Biotechnol 2009;27:997-998.
19. Silva J, Nichols J, Theunissen TW et al. Nanog is the gateway to the pluripotent ground state. Cell 2009;138:722-737.
20. Sumer H, Liu J, Malaver-Ortega LF et al. NANOG is a key factor for induction of pluripotency in bovine adult fibroblasts. J Anim Sci 2011;89:2708-2716.
21. Theunissen TW, van Oosten AL, Castelo-Branco G et al. Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol 2011;21:65-71.
22. Subramanyam D, Lamouille S, Judson RL et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol 2011;29:443-448.
23. Anokye-Danso F, Trivedi CM, Juhr D et al. Highly Efficient miRNAmediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011;8:376-388.
24. Han DW, Greber B, Wu G et al. Direct reprogramming of fibroblasts into epiblast stem cells. Nat Cell Biol 2011;13:66-71.
25. Freberg CT, Dahl JA, Timoskainen S et al. Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. Mol Biol Cell 2007;18:1543-1553.
26. Ramos-Mejia V, Montes R, Bueno C et al. Residual expression of the reprogramming factors prevents differentiation of iPSC generated from human fibroblasts and cord blood CD34+ progenitors. PLoS One 2012;7:e35824.
27. Moon SH, Kim JS, Park SJ et al. Effect of chromosome instability on the maintenance and differentiation of human embryonic stem cells in vitro and in vivo. Stem Cell Res 2011;6:50-59.
28. Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297.
29. Lee MR, Kim JS, Kim KS. miR-124a is important for migratory cell fate transition during gastrulation of human embryonic stem cells. Stem Cellsr 2010;28:1550-1559.
30. Landgraf P, Rusu M, Sheridan R et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007; 129:1401-1414.
31. Gunaratne PH. Embryonic stem cell microRNAs: Defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells? Curr Stem Cell Res Ther 2009;4:168-177.
32. Suh MR, Lee Y, Kim JY et al. Human embryonic stem cells express a unique set of microRNAs. Dev Biol 2004;270:488-498.
33. Barroso-del Jesus A, Lucena-Aguilar G, Menendez P. The miR-302-367 cluster as a potential stemness regulator in ESCs. Cell Cycle 2009;8:394-398.
34. Murray MJ, Halsall DJ, Hook CE et al. Identification of microRNAs From the miR-371-373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors. Am J Clin Pathol 2011;135: 119-125.
35. Voorhoeve PM, le Sage C, Schrier M et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006;124:1169-1181.
36. Barroso-delJesus A, Lucena-Aguilar G, Sanchez L et al. The nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. FASEB J 2011;25:1497-1508.
37. Lin SL, Chang DC, Lin CH et al. Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Res 2010;39:1054-1065.
38. Lee NS, Kim JS, Cho WJ et al. miR-302b maintains "stemness" of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression. Biochem Biophys Res Commun 2008;377: 434-440.
39. Sansom OJ, Maddison K, Clarke AR. Mechanisms of disease: Methylbinding domain proteins as potential therapeutic targets in cancer. Nat Clin Pract Oncol 2007;4:305-315.
40. Kim JK, Samaranayake M, Pradhan S. Epigenetic mechanisms in mammals. Cell Mol Life Sci 2009;66:596-612.
41. Rosa A, Brivanlou AH. A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation. EMBO J 2010;30:237-248.
42. Barroso-delJesus A, Romero-Lopez C, Lucena-Aguilar G et al. Embryonic stem cell-specific miR302-367 cluster: Human gene structure and functional characterization of its core promoter. Mol Cell Biol 2008;28:6609-6619.
43. Gu P, Xu X, Le Menuet D et al. Differential recruitment of methyl CpG-binding domain factors and DNA methyltransferases by the orphan receptor germ cell nuclear factor initiates the repression and silencing of Oct4. Stem Cells 2011;29:1041-1051.
44. Yamanaka S. Elite and stochastic models for induced pluripotent stem cell generation. Nature 2009;460:49-52.
45. Lin SL, Chang DC, Chang-Lin S et al. Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA 2008;14: 2115-2124.
46. Wang J, Rao S, Chu J et al. A protein interaction network for pluripotency of embryonic stem cells. Nature 2006;444:364-368.