Anxiolytic and antidepressant effect of zinc on rats and its impact on general behavioural parameters;Anksioliticki i antidepresivni efekat cinka na pacove i njegov uticaj na opšte bihevioralne parametre

Vojnosanitetski Pregled

Volumn 70, Issue 4, 2013, Pages 391-395

  Samardžic, Janko ^a   Savic, Kristina ^a   Stefanovic, Nemanja ^a   Matunovic, Radomir ^a   Baltezarevic, Dragana ^a   Obradovic, Miljana ^a   Jancic, Jasna ^a   Opric, Dejan ^b   Obradovic, Dragan ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Serbia   (Serbia)

Author keywords

Anti anxiety agents; Antidepressive agents; Rats; Second generation; Zinc

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SOLVENT; UNCLASSIFIED DRUG; ZINC; ZINC HISTIDINE DEHYDRATE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; ENZYME INHIBITION; FORCED SWIMMING TEST; IMMOBILIZATION; LOCOMOTION; MALE; MAZE TEST; NEUROTRANSMISSION; NONHUMAN; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; MALE; MAZE LEARNING; RATS; RATS, WISTAR; SWIMMING; ZINC;

EID: 84875773764     PISSN: 00428450     EISSN: None     Source Type: Journal    
DOI: 10.2298/VSP111129036S     Document Type: Article

References (29)

1. Plum LM, Rink L, Haase H. The essential toxin: impact of zinc on human health. Int J Environ Res Public Health 2010; 7(4): 1342-1365.
2. Popovics P, Stewart AJ. GPR39: a Zn(2+)-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions. Cell Mol Life Sci 2011; 68(1): 85-95.
3. Frederickson CJ, Suh SW, Silva D, Frederickson CJ, Thompson RB. Importance of zinc in the central nervous system: the zinc-containing neuron. J Nutr 2000; 130(5S Suppl): 1471S-1483S.
4. Harrison NL, Gibbons SJ. Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels. Neuropharmacology 1994; 33(8): 935-952.
5. Szewczyk B, Poleszak E, Sowa-Kucma M, Siwek M, Dudek D, Ryszewska-Pokrasniewicz B, et al. Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action. Pharmacol Rep 2008; 60(5): 588-589.
6. Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptor ion channels. Pharmacol Rev 1999; 51(1): 7-61.
7. Casagrande S, Valle L, Cupello A, Robello M. Modulation by Zn(2+) and Cd(2+) of GABA(A) receptors of rat cerebellum granule cells in culture. Eur Biophys J 2003; 32(1): 40-46.
8. Hevers W, Lüddens H. The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes. Mol Neurobiol 1998; 18(1): 35-86.
9. Buhl EH, Otis TS, Mody I. Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science 1996; 271(5247): 369-373.
10. Coulter DA. Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties. Int Rev Neurobiol 2001; 45: 237-252.
11. Cope EC, Levenson CW. Role of zinc in the development and treatment of mood disorders. Curr Opin Clin Nutr Metab Care 2010; 13(6): 685-9.
12. Nowak G, Szewczyk B, Pilc A. Zinc and depression. An update. Pharmacol Rep 2005; 57(6): 713-718.
13. Adamo AM, Oteiza PI. Zinc deficiency and neurodevelopment: the case of neurons. Biofactors 2010; 36(2): 117-124.
14. Koh JY. Endogenous Zinc in Neurological Diseases. J Clin Neurol 2005; 1(2): 121-33.
15. Kroczka B, Brañski P, Palucha A, Pilc A, Nowak G Antidepres-sant-like properties of zinc in rodent forced swim test. Brain Res Bull 2001; 55(2): 297-300.
16. Nowak G, Szewczyk B, Wieronska JM, Branski P, Palucha A, Pilc A, et al. Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats. Brain Res Bull 2003; 61(2): 159-164.
17. Nowak G, Schlegel-Zawadzka M. Alterations in serum and brain trace element levels after antidepressant treatment. Part I. Zinc. Biol Trace Elem Res 1999; 67(1): 85-92.
18. Wong CP, Song Y, Elias VD, Magnusson KR, Ho E. Zinc supplementation increases zinc status and thymopoiesis in aged mice. J Nutr 2009; 139(7):1393-1397.
19. Prasad AS. Impact of the discovery of human zinc deficiency on health. Am Coll Nutr 2009; 28(3): 257-65.
20. Williams RJ, Spencer JP, Goni FM, Rice-Evans CA. Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage. Neurosci Lett 2004; 371(2-3): 106-110.
21. Lister RG The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 1987; 92(2): 180-185.
22. Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 1997; 229(2): 327-336.
23. Szewczyk B, Poleszak E, Sowa-Kucma M, Wrobel A, Slotwinski S, Listos J, et al. The involvement of NMDA and AMPA receptors in the mechanism of antidepressant-like action of zinc in the forced swim test. Amino Acids 2010; 39(1): 205-217.
24. Erreger K, Traynelis SF. Zinc inhibition of rat NR1/NR2A N-methyl-D-aspartate receptors. J Physiol 2008; 586(3): 763-778.
25. Brocardo PS, Assini F, Franco JL, Pandolfo P, Müller YM, Takaha-shi RN. Zinc attenuates malathion-induced depressant-like behavior and confers neuroprotection in the rat brain. Toxicol Sci 2007; 97(1): 140-148.
26. Garcia-Colunga J, Reyes-Haro D, Godoy-Garcia IU, Miledi RZinc modulation of serotonin uptake in the adult rat corpus callo-sum. J Neurosci Res 2005; 80(1): 145-149.
27. Szewczyk B, Poleszak E, Wla P, Wróbel A, Blicharska E, Cichy A, et al. The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test. Prog Neuro-psychopharmacol Biol Psychiatry 2009; 33(2): 323-329.
28. Ruiz A, Walker MC, Fabian-Fine R, Kullmann DM. Endogenous Zinc Inhibits GABAA Receptors in a Hippocampal Pathway. J Neurophysiol 2004; 91(2): 1091-1096.
29. Moazedi AA, Ghotbeddin Z, Parham GH. Comparison of the effects of dose-dependent zinc chloride on short-term and long-term memory in young male rats. Pak J Biol Sci 2007; 10(16): 2704-2708.