Effect of Daikenchuto (TJ-100) on postoperative bowel motility and on prevention of paralytic ileus after pancreaticoduodenectomy: A multicenter, randomized, placebo-controlled phase II trial (The Japan-PD study)

Japanese Journal of Clinical Oncology

Volumn 43, Issue 4, 2013, Pages 436-438

  Okada, Ken Ichi ^a   Kawai, Manabu ^a   Uesaka, Katsuhiko ^b   Kodera, Yasuhiro ^c   Nagano, Hiroaki ^d   Murakami, Yoshiaki ^e   Morita, Satoshi ^f   Sakamoto, Junichi ^c   Yamaue, Hiroki ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b SHIZUOKA CANCER CENTER   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e HIROSHIMA UNIVERSITY   (Japan)

^f YOKOHAMA CITY UNIVERSITY MEDICAL CENTER   (Japan)

Author keywords

Japanese herbal medicine (TJ 100); Pancreaticoduodenectomy; Postoperative paralytic ileus; Surgical site infection

Indexed keywords

DAIKENCHUTO; GASTROINTESTINAL AGENT; KAMPO; TJ 100; UNCLASSIFIED DRUG;

ARTICLE; DAY HOSPITAL; DIARRHEA; DRUG EFFICACY; FLATULENCE; GASTROINTESTINAL SYMPTOM RATING SCALE; HUMAN; INTESTINE MOTILITY; MULTICENTER STUDY; OUTCOME ASSESSMENT; PANCREATICODUODENECTOMY; PARALYTIC ILEUS; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SMALL INTESTINE OBSTRUCTION; SURGICAL INFECTION; VISUAL ANALOG SCALE;

ADULT; DOUBLE-BLIND METHOD; GASTROINTESTINAL MOTILITY; HUMANS; INTESTINAL PSEUDO-OBSTRUCTION; LENGTH OF STAY; PANCREATICODUODENECTOMY; PLANT EXTRACTS; POSTOPERATIVE COMPLICATIONS; QUALITY OF LIFE; SURGICAL WOUND INFECTION;

EID: 84875765431     PISSN: 03682811     EISSN: 14653621     Source Type: Journal    
DOI: 10.1093/jjco/hyt005     Document Type: Article

References (9)

1. Tani M, Kawai M, Hirono S, et al. A prospective randomized controlled trial of internal versus external drainage with pancreaticojejunostomy for pancreaticoduodenectomy. Am J Surg 2010;199:759-64.
2. Kawai M, Tani M, Hirono S, et al. Pylorus ring resection reduces delayed gastric emptying in patients undergoing pancreatoduodenectomy: a prospective, randomized, controlled trial of pylorus-resecting versus pylorus-preserving pancreatoduodenectomy. Ann Surg 2011;253: 495-501.
3. Balzano G, Zerbi A, Braga M, Rocchetti S, Beneduce AA, Di Carlo V. Fast-track recovery programme after pancreatico-duodenectomy reduces delayed gastric emptying. Br J Surg 2008;95:1387-93.
4. Kawai M, Tani M, Terasawa H, et al. Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients. Ann Surg 2006;244:1-7.
5. Endo S, Nishida T, Nishikawa K, et al. Dai-kenchu-to, a Chinese herbal medicine, improves stasis of patients with total gastrectomy and jejunal pouch interposition. Am J Surg 2006;192:9-13.
6. Suehiro T, Matsumata T, Shikada Y, Sugimachi K. The effect of the herbal medicines dai-kenchu-to and keishi-bukuryo-gan on bowel movement after colorectal surgery. Hepatogastroenterology 2005;52: 97-100.
7. Livingston EH, Passaro EP, Jr. Postoperative ileus. Dig Dis Sci 1990;35:121-32.
8. Luckey A, Livingston E, Taché Y. Mechanisms and treatment of postoperative ileus. Arch Surg 2003;138:206-14.
9. Mythen MG. Postoperative gastrointestinal tract dysfunction. Anesth Analg 2005;100:196-204.