Levetiracetam improves verbal memory in high-grade glioma patients

Neuro-Oncology

Volumn 15, Issue 2, 2013, Pages 216-223

  De Groot, Marjolein ^a   Douw, Linda ^a   Sizoo, Eefje M ^a   Bosma, Ingeborg ^a   Froklage, Femke E ^a,b   Heimans, Jan J ^a   Postma, Tjeerd J ^a   Klein, Martin ^a   Reijneveld, Jaap C ^a,c  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Anti epileptic drugs; Cognitive functioning; Epilepsy; High grade glioma; Primary brain tumor

Indexed keywords

ETIRACETAM; PHENYTOIN; VALPROIC ACID;

ADULT; ARTICLE; CANCER GRADING; COGNITIVE DEFECT; CONTROLLED STUDY; EPILEPSY; FEMALE; GLIOMA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NEUROSURGERY; TREATMENT RESPONSE; VERBAL MEMORY;

ADOLESCENT; ADULT; AGED; ANTICONVULSANTS; BRAIN NEOPLASMS; COGNITION DISORDERS; FEMALE; GLIOMA; HUMANS; MALE; MEMORY DISORDERS; MIDDLE AGED; NEOPLASM GRADING; NEUROPSYCHOLOGICAL TESTS; PIRACETAM; PROGNOSIS; PROSPECTIVE STUDIES; PSYCHOMOTOR PERFORMANCE; QUALITY OF LIFE; VERBAL LEARNING; YOUNG ADULT;

EID: 84875759398     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nos288     Document Type: Article

References (38)

1. McGirt MJ, Chaichana KL, Gathinji M, et al. Independent association of extent of resection with survival in patients with malignant brain astrocytoma. J Neurosurg. 2009;110:156-162.
2. van Breemen MS, Wilms EB, Vecht CJ. Epilepsy in patients with brain tumours: Epidemiology, mechanisms, and management. Lancet Neurol. 2007;6:421-430. (Pubitemid 46551867)
3. Rudá R, Trevisan E, Soffietti R, et al. Epilepsy and brain tumors. Curr Opin Oncol. 2010;22:611-620.
4. De Groot M, Reijneveld JC, Aronica A, et al. Epilepsy in patients with a brain tumour: Focal epilepsy requires focused treatment. Brain. 2012;135(Pt 4):1002-1016.
5. Loring DW, Marino S, Meador KJ. Neuropsychological and behavioral effects of antiepilepsy drugs. Neuropsychol Rev. 2007;17:413-425. (Pubitemid 350231552)
6. Hamed SA. The aspects and mechanisms of cognitive alterations in epilepsy: The role of antiepileptic medications. CNS Neurosci Ther. 2009;15:134-156.
7. Meador KJ. Cognitive outcomes and predictive factors in epilepsy. Neurology. 2002;58:S21-S26. (Pubitemid 34415367)
8. Klein M, Taphoorn MJ, Heimans JJ, et al. Neurobehavioral status and health-related quality of life in newly diagnosed high-grade glioma patients. J Clin Oncol. 2001;19:4037-4047. (Pubitemid 32976690)
9. Bosma I, Vos MJ, Heimans JJ, et al. The course of neurocognitive functioning in high-grade glioma patients. Neuro Oncol. 2007; 9:53-62. (Pubitemid 46543489)
10. Douw L, Klein M, Fagel SS, et al. Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: Long-term follow-up. Lancet Neurol. 2009;8:810-818.
11. Klein M, Engelberts NH, van der Ploeg HM, et al. Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life. Ann Neurol. 2003;54:514-520. (Pubitemid 37176548)
12. Piazzini A, Chifari R, Canevini MP, et al. Levetiracetam: An improvement of attention and of oral fluency in patients with partial epilepsy. Epilepsy Res. 2006;68:181-188.
13. Helmstaedter C, Witt JA. The effects of levetiracetam on cognition: A non-interventional surveillance study. Epilepsy Behav. 2008;13:642-649.
14. Wu T, Chen CC, Chen TC,, et al. Clinical efficacy and cognitive and neuropsychological effects of levetiracetam in epilepsy: An open-label multicenter study. Epilepsy Behav. 2009;16:468-474.
15. Zhou B, Zhang Q, Tian L,, et al. Effects of levetiracetam as an add-on therapy on cognitive function and quality of life in patients with refractory partial seizures. Epilepsy Behav. 2008;12:305-310.
16. Hilverda K, Bosma I, Heimans JJ, et al. Cognitive functioning in glioblastoma patients during radiotherapy and temozolomide treatment: Initial findings. J Neurooncol. 2010;97:89-94.
17. Karnofsky DA, Abelmann WH, Craver LF. The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer. 1948;1:634-356.
18. Jolles J, van Boxtel MP, Ponds RW, et al. [The Maastricht aging study (MAAS). The longitudinal perspective of cognitive aging]. Tijdschr Gerontol Geriatr. 1998;29:120-129. (Pubitemid 28297930)
19. Maschio M, Dinapoli L, Sperati F, et al. Levetiracetam monotherapy in patients with brain tumor-related epilepsy: Seizure control, safety, and quality of life. J Neurooncol. 2011;104:205-214.
20. Klein M, Heimans JJ. The measurement of cognitive functioning in lowgrade glioma patients after radiotherapy. J Clin Oncol. 2004;22: 966-967.
21. Lopez-Gongora M, Martinez-Domeno A, Garcia C, Escartin A. Effect of levetiracetam on cognitive functions and quality of life: A one-year follow-up study. Epileptic Disord. 2008;10:297-305.
22. Meador KJ, Gevins A, Leese PT, Otoul C, et al. Neurocognitive effects of brivaracetam, levetiracetam, and lorazepam. Epilepsia. 2011;52: 264-272.
23. Meador KJ, Gevins A, Loring DW, et al. Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam. Neurology. 2007;69:2076-2084. (Pubitemid 350175710)
24. Helmstaedter C, Witt JA. Cognitive outcome of antiepileptic treatment with levetiracetam versus carbamazepine monotherapy: A noninterventional surveillance trial. Epilepsy Behav. 2010;18:74-80.
25. Gomer B, Wagner K, Frings L, et al. The influence of antiepileptic drugs on cognition: A comparison of levetiracetam with topiramate. Epilepsy Behav. 2007;10:486-494. (Pubitemid 46567780)
26. Bootsma HP, Aldenkamp AP, Diepman L, et al. The effect of antiepileptic drugs on cognition: Patient perceived cognitive problems of topiramate versus levetiracetam in clinical practice. Epilepsia. 2006;47(Suppl 2):24-27. (Pubitemid 44684615)
27. Huang CW, Pai MC, Tsai JJ. Comparative cognitive effects of levetiracetam and topiramate in intractable epilepsy. Psychiatry Clin.Neurosci. 2008;62:548-553.
28. Aldenkamp AP, de KM, Reijs R. Newer antiepileptic drugs and cognitive issues. Epilepsia. 2003;44(Suppl 4):21-29. (Pubitemid 36842173)
29. Mecarelli O, Vicenzini E, Pulitano P, et al. Clinical, cognitive, and neurophysiologic correlates of short-term treatment with carbamazepine, oxcarbazepine, and levetiracetam in healthy volunteers. Ann Pharmacother. 2004;38(11):1816-1822. (Pubitemid 39425714)
30. Shamji MF, Fric-Shamji EC, Benoit BG. Brain tumors and epilepsy: Pathophysiology of peritumoral changes. Neurosurg Rev. 2009;32: 275-284.
31. Janz R, Goda Y, Geppert M, et al. SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release. Neuron. 1999; 24:1003-1016. (Pubitemid 30017678)
32. Bobustuc GC, Baker CH, Limaye A, et al. Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide. Neuro Oncol. 2010;12:917-927.
33. Suzuki A, Stern SA, Bozdagi O, et al. Astrocyte-neuron lactate transport is required for long-term memory formation. Cell. 2011;144:810-823.
34. Paola CM, Chifari R, Piazzini A. Improvement of a patient with stuttering on levetiracetam. Neurology. 2002;59:1288. (Pubitemid 35192414)
35. Cumbo E, Ligori LD. Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease. Epilepsy Behav. 2010;17(4):461-466.
36. Dolder CR, Nealy KL. The efficacy and safety of newer anticonvulsants in patients with dementia. Drugs Aging. 2012;29(8):627-637.
37. Dodson WE. Level off. Neurology. 1989;39(8):1009-1010.
38. Commission on Antiepileptic Drugs, International League Against Epilepsy. Guidelines for therapeutic monitoring on antiepileptic drugs. Epilepsia. 1993;34(4):585-587.