Preserved adiposity in the fischer 344 rat devoid of gut microbiota

FASEB Journal

Volumn 27, Issue 4, 2013, Pages 1701-1710

  Swartz, Timothy D ^a,b   Sakar, Yassine ^a   Duca, Frank A ^a,b   Covasa, Mihai ^a,c,d  

^a UMR1319 MICALIS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^d STEFAN CEL MARE UNIVERSITY OF SUCEAVA   (Romania)

Author keywords

FIAF; Germ free; Lipogenesis; Metabolism; Nutrient receptor

Indexed keywords

ENZYME INHIBITOR; FAS ANTIGEN; PROTEIN FASTING INDUCED ADIPOSE FACTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL SIZE; CHEMORECEPTOR; CONTROLLED STUDY; FISCHER 344 RAT; INTESTINE FLORA; LIPOGENESIS; MALE; NONHUMAN; OBESITY; PRESERVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ADIPOCYTES; ADIPOSE TISSUE; ADIPOSITY; ANIMALS; BODY WEIGHT; DIETARY FATS; ENERGY METABOLISM; GERM-FREE LIFE; INTESTINES; LIVER; MALE; METAGENOME; MICE; RATS; RATS, INBRED F344; UP-REGULATION;

MUS; RATTUS;

EID: 84875752062     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-221689     Document Type: Article

References (33)

1. Backhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., and Gordon, J. I. (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. U. S. A. 101, 15718-15723.
2. Backhed, F., Manchester, J. K., Semenkovich, C. F., and Gordon, J. I. (2007) Mechanisms underlying the resistance to dietinduced obesity in germ-free mice. Proc. Natl. Acad. Sci. U. S. A. 104, 979-984.
3. Turnbaugh, P. J., Backhed, F., Fulton, L., and Gordon, J. I. (2008) Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3, 213-223.
4. Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., and Gordon, J. I. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031.
5. Cherbuy, C., Honvo-Houeto, E., Bruneau, A., Bridonneau, C., Mayeur, C., Duee, P. H., Langella, P., and Thomas, M. (2010) Microbiota matures colonic epithelium through a coordinated induction of cell cycle-related proteins in gnotobiotic rat. Am. J. Physiol. Gastrointest. Liver Physiol. 299, G348-G357.
6. Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., and Gordon, J. I. (2008) Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc. Natl. Acad. Sci. U. S. A. 105, 16767-16772.
7. Duca, F. A., and Covasa, M. (2012) Current and emerging concepts on the role of peripheral signals in the control of food intake and development of obesity. Br J. Nutr. 1-16.
8. Duca, F. A., Swartz, T. D., Sakar, Y., and Covasa, M. (2012) Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota. PLoS One 7, e39748.
9. Rabot, S., Membrez, M., Bruneau, A., Gerard, P., Harach, T., Moser, M., Raymond, F., Mansourian, R., and Chou, C. J. (2010) Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. FASEB J. 24, 4948-4959.
10. Fleissner, C. K., Huebel, N., Abd El-Bary, M. M., Loh, G., Klaus, S., and Blaut, M. (2010) Absence of intestinal microbiota does not protect mice from diet-induced obesity. Br. J. Nutr. 104, 919-929.
11. Wostmann, B. S., Larkin, C., Moriarty, A., and Bruckner-Kardoss, E. (1983) Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats. Lab. Anim. Sci. 33, 46-50.
12. Kersten, S., Mandard, S., Tan, N. S., Escher, P., Metzger, D., Chambon, P., Gonzalez, F. J., Desvergne, B., and Wahli, W. (2000) Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J. Biol. Chem. 275, 28488-28493.
13. Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Muller, M., and Kersten, S. (2006) The fastinginduced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J. Biol. Chem. 281, 934-944.
14. Lin, Z. J., Zhang, B., Liu, X. Q., and Yang, H. L. (2009) Abdominal fat accumulation with hyperuricemia and hypercholesterolemia quail model induced by high fat diet. Chin. Med. Sci. J. 24, 191-194.
15. Kawai, Y., Suegara, N., and Yazawa, K. (1981) Intestinal microflora and aging: age-related change of lipid metabolism in germ-free and conventional rats. Mech. Ageing Dev. 16, 149-158.
16. Kahn, B. B., Alquier, T., Carling, D., and Hardie, D. G. (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1, 15-25.
17. Bastie, C., Luquet, S., Holst, D., Jehl-Pietri, C., and Grimaldi, P. A. (2000) Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation. J. Biol. Chem. 275, 38768-38773.
18. Jernas, M., Palming, J., Sjoholm, K., Jennische, E., Svensson, P. A., Gabrielsson, B. G., Levin, M., Sjogren, A., Rudemo, M., Lystig, T. C., Carlsson, B., Carlsson, L. M., and Lonn, M. (2006) Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J. 20, 1540-1542.
19. Weyer, C., Foley, J. E., Bogardus, C., Tataranni, P. A., and Pratley, R. E. (2000) Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 43, 1498-1506.
20. Hayes, M. R., Bradley, L., and Grill, H. J. (2009) Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling. Endocrinology 150, 2654-2659.
21. Williams, D. L., Baskin, D. G., and Schwartz, M. W. (2006) Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation. Diabetes 55, 3387-3393.
22. Williams, D. L., Baskin, D. G., and Schwartz, M. W. (2009) Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety. Endocrinology 150, 1680-1687.
23. Ruttimann, E. B., Arnold, M., Geary, N., and Langhans, W. (2010) GLP-1 antagonism with exendin (9-39) fails to increase spontaneous meal size in rats. Physiol. Behav. 100, 291-296.
24. Liou, A. P., Lu, X., Sei, Y., Zhao, X., Pechhold, S., Carrero, R. J., Raybould, H. E., and Wank, S. (2011) The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. Gastroenterology 140, 903-912.
25. Liou, A. P., Sei, Y., Zhao, X., Feng, J., Lu, X., Thomas, C., Pechhold, S., Raybould, H. E., and Wank, S. A. (2011) The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G538-G546.
26. Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., and Tsujimoto, G. (2005) Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat. Med. 11, 90-94.
27. Tanaka, T., Yano, T., Adachi, T., Koshimizu, T. A., Hirasawa, A., and Tsujimoto, G. (2008) Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. Naunyn Schmiedebergs Arch. Pharmacol. 377, 515-522.
28. Tazoe, H., Otomo, Y., Kaji, I., Tanaka, R., Karaki, S. I., and Kuwahara, A. (2008) Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J. Physiol. Pharmacol. 59(Suppl. 2), 251-262.
29. Karaki, S., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J. B., and Kuwahara, A. (2006) Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res. 324, 353-360.
30. Karaki, S., Tazoe, H., Hayashi, H., Kashiwabara, H., Tooyama, K., Suzuki, Y., and Kuwahara, A. (2008) Expression of the short-chain fatty acid receptor, GPR43, in the human colon. J. Mol. Histol. 39, 135-142.
31. Edfalk, S., Steneberg, P., and Edlund, H. (2008) Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes 57, 2280-2287.
32. Duca, F. A., Swartz, T. D., Sakar, Y., and Covasa, M. (2012) Decreased intestinal nutrient response in diet-induced obese rats: role of gut peptides and nutrient receptors. [E-pub ahead of print] Int. J. Obes (Lond.) doi: 10.1038/ijo.2012.45.
33. De La Serre, C. B., Ellis, C. L., Lee, J., Hartman, A. L., Rutledge, J. C., and Raybould, H. E. (2010) Propensity to high-fat dietinduced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 299, G440-G448.