Tumor-infiltrating mast cells in colorectal cancer as a poor prognostic factor

International Journal of Surgical Pathology

Volumn 21, Issue 2, 2013, Pages 111-120

  Wu, Xianrui ^a   Zou, Yifeng ^a   He, Xiaosheng ^a   Yuan, Ruixue ^a   Chen, Yufeng ^a   Lan, Nan ^a   Lian, Lei ^a   Wang, Fengwei ^a   Fan, Xinjuan ^a   Zeng, Yang ^a   Ke, Jia ^a   Wu, Xiaojian ^a   Lan, Ping ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

colorectal neoplasms; immunohistochemical staining; mast cells; prognosis

Indexed keywords

BIOLOGICAL MARKER; CARCINOEMBRYONIC ANTIGEN; TUMOR MARKER;

ADULT; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL DENSITY; CELL INFILTRATION; CLINICAL FEATURE; COHORT ANALYSIS; COLORECTAL CANCER; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MAST CELL; OVERALL SURVIVAL; PRIORITY JOURNAL; RISK FACTOR; STATISTICAL SIGNIFICANCE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR DIFFERENTIATION; COLORECTAL TUMOR; IMMUNOLOGY; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; TUMOR MICROENVIRONMENT;

COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MAST CELLS; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT;

EID: 84875740723     PISSN: 10668969     EISSN: 19402465     Source Type: Journal    
DOI: 10.1177/1066896912448836     Document Type: Article

References (43)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D.. Global cancer statistics. CA Cancer J Clin. 2011 ; 61: 69-90
2. Huang Y, Li W, Chu D, et al. Overexpression of matrix metalloproteinase-21 is associated with poor overall survival of patients with colorectal cancer. J Gastrointest Surg. 2011 ; 15: 1188-1194
3. Hanahan D, Weinberg RA.. Hallmarks of cancer: the next generation. Cell. 2011 ; 144: 646-674
4. Eaden JA, Abrams KR, Mayberry JF.. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001 ; 48: 526-535
5. Heijmans J, Buller NV, Muncan V, van den Brink GR.. Role of mast cells in colorectal cancer development, the jury is still out. Biochim Biophys Acta. 2012 ; 1822: 9-13
6. Strouch MJ, Cheon EC, Salabat MR, et al. Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression. Clin Cancer Res. 2010 ; 16: 2257-2265
7. Chang DZ, Ma Y, Ji B, et al. Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma. Clin Cancer Res. 2011 ; 17: 7015-7023
8. Johansson A, Rudolfsson S, Hammarsten P, et al. Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy. Am J Pathol. 2010 ; 177: 1031-1041
9. Pittoni P, Tripodo C, Piconese S, et al. Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers. Cancer Res. 2011 ; 71: 5987-5997
10. Melillo RM, Guarino V, Avilla E, et al. Mast cells have a protumorigenic role in human thyroid cancer. Oncogene. 2010 ; 29: 6203-6215
11. Ju MJ, Qiu SJ, Gao Q, et al. Combination of peritumoral mast cells and T-regulatory cells predicts prognosis of hepatocellular carcinoma. Cancer Sci. 2009 ; 100: 1267-1274
12. Ali G, Boldrini L, Lucchi M, Mussi A, Corsi V, Fontanini G.. Tryptase mast cells in malignant pleural mesothelioma as an independent favorable prognostic factor. J Thorac Oncol. 2009 ; 4: 348-354
13. Welsh TJ, Green RH, Richardson D, Waller DA, O'Byrne KJ, Bradding P.. Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol. 2005 ; 23: 8959-8967
14. Rajput AB, Turbin DA, Cheang MC, et al. Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases. Breast Cancer Res Treat. 2008 ; 107: 249-257
15. Liu J, Zhang Y, Zhao J, et al. Mast cell: insight into remodeling a tumor microenvironment. Cancer Metastasis Rev. 2011 ; 30: 177-184
16. Maltby S, Khazaie K, McNagny KM.. Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation. Biochim Biophys Acta. 2009 ; 1796: 19-26
17. Pages F, Galon J, Dieu-Nosjean MC, Tartour E, Sautes-Fridman C, Fridman WH.. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene. 2010 ; 29: 1093-1102
18. Camp RL, Dolled-Filhart M, Rimm DL.. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res. 2004 ; 10: 7252-7259
19. Cai MY, Hou JH, Rao HL, et al. High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients. Mol Med. 2011 ; 17: 12-20
20. Raeside DE.. Monte Carlo principles and applications. Phys Med Biol. 1976 ; 21: 181-197
21. O'Connell JB, Maggard MA, Ko CY.. Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst. 2004 ; 96: 1420-1425
22. Nagtegaal ID, Quirke P.. Revised staging: is it really better, or do we not know?. J Clin Oncol. 2010 ; 28: e397 - e398
23. Ratto C, Ricci R.. Potential pitfalls concerning colorectal cancer classification in the seventh edition of the AJCC Cancer Staging Manual. Dis Colon Rectum. 2011 ; 54: e232
24. Thirunavukarasu P, Sukumar S, Sathaiah M, et al. C-stage in colon cancer: implications of carcinoembryonic antigen biomarker in staging, prognosis, and management. J Natl Cancer Inst. 2011 ; 103: 689-697
25. Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006 ; 313: 1960-1964
26. Pages F, Berger A, Camus M, et al. Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med. 2005 ; 353: 2654-2666
27. Pages F, Kirilovsky A, Mlecnik B, et al. In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J Clin Oncol. 2009 ; 27: 5944-5951
28. Laghi L, Bianchi P, Miranda E, et al. CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study. Lancet Oncol. 2009 ; 10: 877-884
29. Kim MS, Chae HJ, Shin TY, Kim HM, Kim HR.. Estrogen regulates cytokine release in human mast cells. Immunopharmacol Immunotoxicol. 2001 ; 23: 495-504
30. Taskinen M, Karjalainen-Lindsberg ML, Leppa S.. Prognostic influence of tumor-infiltrating mast cells in patients with follicular lymphoma treated with rituximab and CHOP. Blood. 2008 ; 111: 4664-4667
31. Coussens LM, Raymond WW, Bergers G, et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 1999 ; 13: 1382-1397
32. Qu Z, Huang X, Ahmadi P, et al. Synthesis of basic fibroblast growth factor by murine mast cells: regulation by transforming growth factor beta, tumor necrosis factor alpha, and stem cell factor. Int Arch Allergy Immunol. 1998 ; 115: 47-54
33. Rakusan K, Sarkar K, Turek Z, Wicker P.. Mast cells in the rat heart during normal growth and in cardiac hypertrophy. Circ Res. 1990 ; 66: 511-516
34. Shin K, Nigrovic PA, Crish J, et al. Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes. J Immunol. 2009 ; 182: 647-656
35. Coussens LM, Werb Z.. Matrix metalloproteinases and the development of cancer. Chem Biol. 1996 ; 3: 895-904
36. Lu LF, Lind EF, Gondek DC, et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature. 2006 ; 442: 997-1002
37. Gounaris E, Erdman SE, Restaino C, et al. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A. 2007 ; 104: 19977-19982
38. Fisher ER, Paik SM, Rockette H, Jones J, Caplan R, Fisher B.. Prognostic significance of eosinophils and mast cells in rectal cancer: findings from the National Surgical Adjuvant Breast and Bowel Project (protocol R-01). Hum Pathol. 1989 ; 20: 159-163
39. Acikalin MF, Oner U, Topcu I, Yasar B, Kiper H, Colak E.. Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas. Dig Liver Dis. 2005 ; 37: 162-169
40. Gulubova M, Vlaykova T.. Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer. J Gastroenterol Hepatol. 2009 ; 24: 1265-1275
41. Xia Q, Wu XJ, Zhou Q, et al. No relationship between the distribution of mast cells and the survival of stage IIIB colon cancer patients. J Transl Med. 2011 ; 9: 88
42. Yodavudh S, Tangjitgamol S, Puangsa-art S.. Prognostic significance of microvessel density and mast cell density for the survival of Thai patients with primary colorectal cancer. J Med Assoc Thai. 2008 ; 91: 723-732
43. Nielsen HJ, Hansen U, Christensen IJ, Reimert CM, Brunner N, Moesgaard F.. Independent prognostic value of eosinophil and mast cell infiltration in colorectal cancer tissue. J Pathol. 1999 ; 189: 487-495