Epithelial mesenchymal transition in urothelial carcinoma: Twist in the tale

Indian Journal of Pathology and Microbiology

Volumn 55, Issue 4, 2012, Pages 443-449

  Paliwal, Purnima ^a   Arora, Disha ^a   Mishra, Ashwani K ^a  

^a SAFDARJUNG HOSPITAL   (India)

Author keywords

Epithelial mesenchymal transition; transitional cell carcinoma; twist; urothelial carcinoma

Indexed keywords

CYTOKERATIN; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR TWIST; UVOMORULIN; VIMENTIN;

ADULT; AGED; ARTICLE; BLADDER CARCINOMA; CANCER GRADING; CANCER STAGING; CANCER SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTECTOMY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; PRIMARY UROTHELIAL CARCINOMA OF BLADDER; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; CADHERINS; CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HISTOCYTOCHEMISTRY; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; MALE; MICROSCOPY; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS; UROTHELIUM; VIMENTIN;

EID: 84875731168     PISSN: 03774929     EISSN: 09745130     Source Type: Journal    
DOI: 10.4103/0377-4929.107777     Document Type: Article

References (23)

1. Blick T, Widodo E, Hugo H, Waltham M, Lenburg ME, Neve RM, et al. Epithelial mesenchymal transition traits in human breast cancer cell lines. Clin Exp Metastasis 2008;25:629-42.
2. Rosivatz E, Becker KF, Kremmer E, Schott C, Blechschmidt K, Hofler H, et al. Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract. Virchows Arch 2006;448:277-87.
3. Fondrevelle M, Kantelip B, Reiter RE, Chopin DK, Thiery JP, Monnien F, et al. The expression of Twist has an impact on survival in human bladder cancer and is influenced by the smoking status. Urol Oncol 2009;27:268-76.
4. Baumgart E, Cohen MS, Neto BS, Jacobs MA, Wotkowicz C, Rieger-Christ KM, et al. Identification and prognostic significance of an epithelial-mesenchymal transition expression profile in human bladder tumors. Clin Cancer Res 2007;13:1685-94.
5. Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004;117:927-39.
6. Gravdal K, Halvorsen OJ, Haukaas SA, Akslen LA. A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin Cancer Res 2007;13:7003-11.
7. Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y, Johnson KR. Cadherin switching. J Cell Sci 2008;121:727-35.
8. Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype Nat Rev Cancer 2007;7:415-28.
9. Schaafsma HE, Ramaekers FC, van Muijen GN, Lane EB, Leigh M, Robben H, et al. Distribution of cytokeratin polypeptides in human transitional cell carcinomas, with special emphasis on changing expression patterns during tumor progression. Am J Pathol 1990;136:329-43.
10. Ivaska J, Pallari HM, Nevo J, Eriksson JE. Novel functions of vimentin in cell adhesion, migration, and signalling. Exp Cell Res 2007;313:2050-62.
11. Lang SH, Hyde C, Reid IN, Hitchcock IS, Hart CA, Gordon Bryden AA, et al. Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma. Prostate 2002;52:253-63.
12. McConkey D, Lee S, Choi W, Tran M, Majewski T, Lee S, et al. Molecular genetics of bladder cancer: Emerging mechanisms of tumor initiation and progression. Urol Oncol 2010;28:429-40.
13. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991;113:173-85.
14. Byrne RR, Shariat SF, Brown R, Kattan MW, Morton RA Jr, Wheeler TM, et al. E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term followup. J Urol 2001;165:1473-9.
15. Stanczak A, Stec R, Bodnar L, Olszewski W, Cichowicz M, Kowzlowski W, et al. Prognostic significance of Wnt-1,-catenin and E-cadherin expression in advanced colorectal carcinoma. Pathol Oncol Res 2011;17:955-63.
16. Bringuier PP, Umbas R, Schaafsma HE, Karthaus HF, Debruyne FM, Schalken JA. Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors. Cancer Res 1993;53:3241-5.
17. Bryan RT, Atherfold PA, Yeo Y, Jones LJ, Harrison RF, Wallace DM, et al. Cadherin switching dictates the biology of transitional cell carcinoma of the bladder: Ex vivo and in vitro studies. J Pathol 2008;215:184-94.
18. Jäger T, Becker M, Eisenhardt A, Tilki D, Totsch M, Schmid KW, et al. The prognostic value of cadherin switch in bladder cancer. Oncol Rep 2010;23:1125-32.
19. Wallerand H, Robert G, Pasticier G, Ravaud A, Ballanger P, Reiter RE, et al. The epithelial-mesenchymal transition-inducing factor TWIST is an attractive target in advanced and/or metastatic bladder and prostate cancers. Urol Oncol 2010;28:473-9.
20. Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009;119:1429-37.
21. Sasaki K, Natsugoe S, Ishigami S, Matsumoto M, Okumura H, Setoyama T, et al. Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma. J Exp Clin Cancer Res 2009;28:158-66.
22. Kang Y, Massague J. Epithelial-mesenchymal transitions: TWIST in development and metastasis. Cell 2004;118:277-9.
23. Barr S, Thomson S, Buck E, Russo S, Petti F, Sujka-Kwok I, et al. Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal- like transitions. Clin Exp Metastasis 2008;25:685-93.