ROS-mediated downregulation of MYPT1 in smooth muscle cells: A potential mechanism for the aberrant contractility in atherosclerosis

Laboratory Investigation

Volumn 93, Issue 4, 2013, Pages 422-433

  Cheng, Jung Chien ^a   Cheng, Hui Pin ^a   Tsai, I Ching ^a,b   Jiang, Meei Jyh ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

atherosclerosis; contractility; myosin phosphatase; reactive oxygen species; smooth muscle

Indexed keywords

6 ANILINO 5,8 QUINOLINEQUINONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; ESTROGEN; MYPT1 PROTEIN; PEROXYNITRITE; PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ESTROGEN THERAPY; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; ATHEROSCLEROSIS; CELL MOVEMENT; CELLS, CULTURED; DOWN-REGULATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYDROGEN PEROXIDE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, SMOOTH MUSCLE; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PEROXYNITROUS ACID; PLATELET-DERIVED GROWTH FACTOR; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; STRESS FIBERS; SUPEROXIDE DISMUTASE;

EID: 84875717537     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2013.40     Document Type: Article

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