Could magnesium depletion play a role on fracture risk in PPI users?

Archives of Internal Medicine

Volumn 170, Issue 19, 2010, Pages 1776-

  Faulhaber, Gustavo Adolpho Moreira ^a   Furlanetto, Tania Weber ^a,b  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

PROTON PUMP INHIBITOR; MAGNESIUM;

BONE DENSITY; BONE METABOLISM; BONE STRENGTH; CELL COUNT; DISEASE ASSOCIATION; DRUG UTILIZATION; FRACTURE; HIGH RISK POPULATION; HUMAN; HYPOMAGNESEMIA; HYPOPARATHYROIDISM; LETTER; MAGNESIUM DEPLETION; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RISK FACTOR; ANIMAL; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; FRACTURES, BONE; MAGNESIUM DEFICIENCY; METABOLISM; RAT;

ANIMALS; BONE DENSITY; DISEASE MODELS, ANIMAL; FRACTURES, BONE; HUMANS; MAGNESIUM; MAGNESIUM DEFICIENCY; PROTON PUMP INHIBITORS; RATS; RISK FACTORS;

EID: 78049263414     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinternmed.2010.374     Document Type: Letter

References (5)

1. Gray SL, LaCroix AZ, Larson J, et al. Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative. Arch Intern Med. 2010;170(9):765-771.
2. Epstein M, McGrath S, Law F. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism. N Engl J Med. 2006;355(17):1834-1836.
3. Broeren MA, Geerdink EA, Vader HL, van den Wall Bake AW. Hypomagnesemia induced by several proton-pump inhibitors. Ann Intern Med. 2009;151(10):755-756.
4. Rude RK, Singer FR, Gruber HE. Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr. 2009;28(2):131-141.
5. Kenney MA, McCoy H, Williams L. Effects of magnesium deficiency on strength, mass, and composition of rat femur. Calcif Tissue Int. 1994;54(1):44-49. (Pubitemid 24010516)