RORγt+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury

Journal of Molecular Cell Biology

Volumn 5, Issue 2, 2013, Pages 143-146

  Tan, Zhongming ^a,b,c   Jiang, Runqiu ^a   Wang, Xuehao ^a   Wang, Youjing ^a   Lu, Ling ^a,d   Liu, Qianghui ^a   Zheng, Song Guo ^d   Sun, Beicheng ^a   Ryffel, Bernhard ^b,c  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITÉ D'ORLÉANS   (France)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR RELATED ORPHAN RECEPTOR GAMMA T; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ALLERGIC ENCEPHALOMYELITIS; GENE INACTIVATION; GRAFT REJECTION; HUMAN; LETTER; LIVER CELL CARCINOMA; LIVER HOMOGENATE; LIVER ISCHEMIA; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NICK END LABELING; PARTIAL HEPATECTOMY; PROTEIN EXPRESSION; REPERFUSION INJURY; RESPIRATORY BURST; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION;

ANIMALS; INTERLEUKIN-17; LIVER; LIVER DISEASES; MICE; MICE, KNOCKOUT; NEUTROPHILS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; REPERFUSION INJURY;

EID: 84875699804     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjs065     Document Type: Letter

References (12)

1. Besnard, A.G., Togbe, D., Couillin, I., et al., (2012). Inflammasome-IL-1-Th17 response in allergic lung inflammation. J. Mol. Cell Biol. 4, 3-10.
2. Bettelli, E., Korn, T., Oukka, M., et al., (2008) Induction and effector functions of T(H)17 cells. Nature 453, 1051-1057.
3. Cua, D.J., and Tato, C.M., (2010). Innate IL-17-producing cells: The sentinels of the immune system. Nat. Rev. Immunol. 10, 479-489.
4. Daley, J.M., Thomay, A.A., Connolly, M.D., et al., (2008). Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J. Leukoc. Biol. 83, 64-70.
5. Ferretti, S., Bonneau, O., Dubois, G.R., et al., (2003). IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J. Immunol. 170, 2106-2112.
6. Gasse, P., Riteau, N., Vacher, R., et al., (2011). IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. PLoS One 6, e23185.
7. Kono, H., Fujii, H., Ogiku, M., et al., (2011). Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice. J. Immunol. 187, 4818-4825.
8. Llacuna, L., Mari, M., Lluis, J.M., et al., (2009). Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion. Am. J. Pathol. 174, 1776-1785.
9. Mantovani, A., Cassatella, M.A., Costantini, C., et al., (2011). Neutrophils in the activation and regulation of innate and adaptive immunity. Nat. Rev. Immunol. 11, 519-531.
10. Moran, E.M., Heydrich, R., Ng, C.T., et al., (2011). IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates. PLoS One 6, e24048.
11. Park, S.W., Kim, M., Brown, K.M., et al., (2011). Paneth cell-derived interleukine-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury. Hepatology 53, 1662-75.
12. Xiao, H., Heeringa, P., Liu, Z., et al., (2005). The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies. Am. J. Pathol. 167, 39-45.